INT54002

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Context Info
Confidence 0.20
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.05
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 3
DRG 1
dorsal horn 1
Dh (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 102 100.00 Very High Very High Very High
Dorsal horn 11 100.00 Very High Very High Very High
Hippocampus 11 100.00 Very High Very High Very High
long-term potentiation 168 99.72 Very High Very High Very High
Central grey 1 99.38 Very High Very High Very High
Dopamine 2 97.70 Very High Very High Very High
Locus ceruleus 2 97.32 Very High Very High Very High
antagonist 6 94.80 High High
medulla 2 94.34 High High
adenocard 18 94.00 High High
Disease Link Frequency Relevance Heat
Nociception 9 99.96 Very High Very High Very High
Urological Neuroanatomy 2 99.56 Very High Very High Very High
Neuropathic Pain 17 94.00 High High
Pain 26 88.24 High High
Hypersensitivity 6 87.48 High High
Nervous System Injury 3 85.84 High High
Injury 7 75.00 Quite High
Paralysis 1 66.88 Quite High
INFLAMMATION 7 59.20 Quite High
Hyperalgesia 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin (3 mg/kg, s.c.), but not celecoxib or NS-398 (both at 6 mg/kg, s.c.), reduced both DRG and DH activity.
Negative_regulation (reduced) of DH in DRG associated with dorsal horn
1) Confidence 0.20 Published 2001 Journal Brain Res. Section Abstract Doc Link 11516414 Disease Relevance 0.66 Pain Relevance 0.63
LTP in the mouse DH in vivo was prevented by either EphB2-Fc or targeted mutation of EphB1 receptor
Negative_regulation (prevented) of DH associated with spinal dorsal horn and long-term potentiation
2) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.43
Representative photomicrographs and the corresponding counts of Fos-like immunoreactive neurons in the DH are shown in Fig. 4.
Negative_regulation (shown) of DH in neurons associated with spinal dorsal horn
3) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.29
One of the most accepted hypotheses, sponsored by Tsubokawa among others, proposes that VB stimulation excites raphespinal and reticulospinal neurons of the rostroventral medulla which in turn send respectively inhibitory serotonergic and noradrenergic axons through both dorsolateral funiculi (DLF) to the dorsal horn (DHA) nociceptive neurons; this pathway would be the same as is involved in periventricular-periaqueductal gray (PVG-PAG) stimulation induced inhibition of DH nociceptive neurons.
Negative_regulation (inhibition) of DH in neurons associated with nociception, medulla, dorsal horn, urological neuroanatomy and central grey
4) Confidence 0.15 Published 1994 Journal Arq Neuropsiquiatr Section Abstract Doc Link 7893214 Disease Relevance 0.89 Pain Relevance 0.63
Retrieval testing, 48 h after treatment, showed that post-acquisition bilateral DH blockade caused PAR impairment only when performed 0.25 or 1.5 h after acquisition.
Negative_regulation (blockade) of DH associated with hippocampus
5) Confidence 0.13 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883885 Disease Relevance 0 Pain Relevance 0.88
Anti-dopamine hydroxylase (DH)-saporin treatment reduce spinal norepinephrine content by 97%, accompanied by an almost complete loss of DH immunoreactive axons in the spinal dorsal horn and neurons in the locus coeruleus.
Negative_regulation (loss) of DH in neurons associated with dopamine, locus ceruleus and spinal dorsal horn
6) Confidence 0.12 Published 2002 Journal Pain Section Abstract Doc Link 12031785 Disease Relevance 0.75 Pain Relevance 1.10
Anti-dopamine hydroxylase (DH)-saporin treatment reduce spinal norepinephrine content by 97%, accompanied by an almost complete loss of DH immunoreactive axons in the spinal dorsal horn and neurons in the locus coeruleus.
Negative_regulation (loss) of DH in dorsal horn associated with dopamine, locus ceruleus and spinal dorsal horn
7) Confidence 0.04 Published 2002 Journal Pain Section Abstract Doc Link 12031785 Disease Relevance 0.75 Pain Relevance 1.10

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