INT5401

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Context Info
Confidence 0.78
First Reported 1972
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 1.92
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DBH) extracellular region (DBH) cellular nitrogen compound metabolic process (DBH)
cytoplasm (DBH)
Anatomy Link Frequency
plasma 3
papillae 2
blood 2
nerves 2
long bones 1
DBH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 91 100.00 Very High Very High Very High
Catecholamine 15 100.00 Very High Very High Very High
noradrenaline 5 100.00 Very High Very High Very High
Enkephalin 27 99.98 Very High Very High Very High
Cholecystokinin 2 99.62 Very High Very High Very High
Somatostatin 7 99.42 Very High Very High Very High
Calcitonin gene-related peptide 5 99.12 Very High Very High Very High
ketamine 5 98.92 Very High Very High Very High
Opioid 4 98.52 Very High Very High Very High
Serotonin 1 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 2 98.76 Very High Very High Very High
Pressure Volume 2 Under Development 2 96.08 Very High Very High Very High
Adhesions 1 92.00 High High
Pheochromocytoma 2 88.80 High High
Hemorrhage 4 82.88 Quite High
Reprotox - General 1 1 78.80 Quite High
Stress 2 77.68 Quite High
Taste Disorders 2 75.20 Quite High
Hypertension 4 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intravenous administration of ketamine hydrochloride to fifteen patients undergoing surgery produced no change in circulating plasma dopamine-beta-hydroxylase (DBH), although it produced a significant increase both in systolic blood pressure (BP) and diastolic BP during anesthesia.
Neg (no) Gene_expression (produced) of DBH in plasma associated with anesthesia, dopamine and ketamine
1) Confidence 0.78 Published 1992 Journal Mater Med Pol Section Abstract Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.52
Changes in human plasma catecholamines and dopamine-beta-hydroxylase produced by prostaglandin F2 alpha.
Gene_expression (produced) of dopamine-beta-hydroxylase in plasma associated with dopamine and catecholamine
2) Confidence 0.78 Published 1972 Journal Prostaglandins Section Title Doc Link 4653736 Disease Relevance 0.24 Pain Relevance 0.35
The intravenous administration of ketamine hydrochloride to fifteen patients undergoing surgery produced no change in circulating plasma dopamine-beta-hydroxylase (DBH), although it produced a significant increase both in systolic blood pressure (BP) and diastolic BP during anesthesia.
Neg (no) Gene_expression (produced) of dopamine-beta-hydroxylase in plasma associated with anesthesia, dopamine and ketamine
3) Confidence 0.68 Published 1992 Journal Mater Med Pol Section Abstract Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.52
Recognition of specific defects, such as the inability to synthesize norepinephrine in isolated dopamine beta-hydroxylase deficiency, suggests that sympathetic nerves may influence blood pressure regulation through nonadrenergic mechanisms (dopamine, neuropeptides, and purines).
Gene_expression (deficiency) of dopamine beta-hydroxylase in blood associated with dopamine and neuropeptide
4) Confidence 0.68 Published 1991 Journal Hypertension Section Abstract Doc Link 1937684 Disease Relevance 0.32 Pain Relevance 0.15
Tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) activities, dopamine (DA), noradrenaline (NA), adrenaline (A), met 5-enkephalin (Met-Enk), leu5-enkephalin (Leu-Enk), dynorphin (Dyn) and beta-endorphin (beta-end) were measured simultaneously in ten human pheochromocytomas = 1 - TH activity was highly variable, from 22 to 2220 U/g tissue. 2 - DBH activity, in contrast, was rather constant, from 96 to 582 U/g. 3 - Catecholamines (A and NA) concentrations showed only small variations. 4 - The four opioid peptides were detected in all cases and exhibited a wide range of tissue concentrations (Enk much greater than Dyn greater than beta-end). 5 - Met-Enk and Leu-Enk concentrations were highly correlated; no correlation was observed with the other opioid peptides. 6 - A very strong correlation was observed between enkephalins concentrations and both catecholamines concentrations and DBH activities.
Gene_expression (concentrations) of DBH associated with dopamine, dynorphin, catecholamine, noradrenaline, enkephalin, opioid and pheochromocytoma
5) Confidence 0.66 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6144074 Disease Relevance 0.16 Pain Relevance 1.15
The human fetal sympathetic ganglia were studied using the indirect peroxidase-antiperoxidase PAP method for immunocytochemical demonstration of three catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) as well as the neuropeptides leucine (Leu5)-enkephalin and substance P.
Gene_expression (using) of dopamine-beta-hydroxylase in ganglia associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
6) Confidence 0.66 Published 1981 Journal Cell Tissue Res. Section Abstract Doc Link 6162566 Disease Relevance 0.07 Pain Relevance 0.47
Dopamine beta-hydroxylase could be detected at 15 weeks, followed by leu-enkephalin and phenylethanolamine N-methyltransferase at 18-19 weeks.
Gene_expression (detected) of Dopamine beta-hydroxylase associated with dopamine and enkephalin
7) Confidence 0.63 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2427537 Disease Relevance 0.08 Pain Relevance 1.13
Fortunately, we did not observe allograft-related immunological adverse reactions in our study but this potential problem should be considered using DBM.
Gene_expression (using) of DBM associated with adverse drug reaction
8) Confidence 0.59 Published 2009 Journal J Trauma Manag Outcomes Section Body Doc Link PMC2801473 Disease Relevance 0.31 Pain Relevance 0
Nevertheless, there still is a lack of clinical studies: A recent MEDLINE search using the term "demineralized bone matrix" restricted to "clinical study" and "English language" demonstrated, that only four references were found that were dealing with DBM-treatment in cases of a non-union of long bones [5,19-22].
Gene_expression (dealing) of DBM in long bones
9) Confidence 0.59 Published 2009 Journal J Trauma Manag Outcomes Section Body Doc Link PMC2801473 Disease Relevance 0.42 Pain Relevance 0.07
Incubation with the antibodies against somatostatin, enkephalin, bombesin, peptide histidine isoleucine amide (PHI), cholecystokinin (CCK)/gastrin and dopamine-beta-hydroxylase (DBH) was negative for the fungiform papillae.
Neg (negative) Gene_expression (negative) of DBH in papillae associated with dopamine, somatostatin, enkephalin and cholecystokinin
10) Confidence 0.57 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8577944 Disease Relevance 0.08 Pain Relevance 0.40
Incubation with the antibodies against somatostatin, enkephalin, bombesin, peptide histidine isoleucine amide (PHI), cholecystokinin (CCK)/gastrin and dopamine-beta-hydroxylase (DBH) was negative for the fungiform papillae.
Neg (negative) Gene_expression (negative) of dopamine-beta-hydroxylase in papillae associated with dopamine, somatostatin, enkephalin and cholecystokinin
11) Confidence 0.57 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8577944 Disease Relevance 0.08 Pain Relevance 0.40
Immunohistochemical studies have confirmed the presence of catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the majority of fine, varicose intramuscular nerves, about two-thirds of which also contain neuropeptide Y (NPY).
Gene_expression (presence) of dopamine beta hydroxylase in nerves associated with dopamine, catecholamine and neuropeptide
12) Confidence 0.44 Published 1998 Journal Microsc. Res. Tech. Section Abstract Doc Link 9817549 Disease Relevance 0 Pain Relevance 0.28
We were able to reveal immunoreactivity for enzymes involved in the synthesis of the catecholamines dopamine and noradrenaline (tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine-beta-hydroxylase), for the indolamine 5-hydroxytryptamine (serotonin), as well as for a number of well-known neuronal markers such as the neurofilament protein 200, synaptophysin, chromogranin A + B, the neural cell-adhesion molecule (N-CAM), the microtubule-associated protein (MAP-2), and the calcium-binding proteins: S-100, calbindin and parvalbumin.
Gene_expression (synthesis) of dopamine-beta-hydroxylase in neural associated with dopamine, catecholamine, noradrenaline, serotonin and adhesions
13) Confidence 0.43 Published 1993 Journal Cell Tissue Res. Section Abstract Doc Link 8472301 Disease Relevance 0.09 Pain Relevance 0.25
DBM and its metabolites were found in both blood and brain as early as 1 min after i.v. administration of DBM.
Gene_expression (found) of DBM in brain
14) Confidence 0.40 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3779514 Disease Relevance 0 Pain Relevance 0.41
In contrast, few neuropeptide Y-, met-enkephalin-, leu-enkephalin-, calcitonin gene-related peptide-, somatostatin-, 5-hydroxytryptamine-, and dopamine beta-hydroxylase-immunoreactive nerves were found in these regions.
Gene_expression (found) of dopamine beta-hydroxylase in nerves associated with dopamine, somatostatin, neuropeptide, enkephalin and calcitonin gene-related peptide
15) Confidence 0.33 Published 1992 Journal Gastroenterology Section Abstract Doc Link 1370660 Disease Relevance 0.07 Pain Relevance 1.24
The phenotypic characterization of A11 neurons showed that, although they are TH-immunopositive, they do not express DBH or AADC.
Neg (not) Gene_expression (express) of DBH in neurons
16) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.28
DBM and its metabolites were found in both blood and brain as early as 1 min after i.v. administration of DBM.
Gene_expression (found) of DBM in blood
17) Confidence 0.14 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3779514 Disease Relevance 0 Pain Relevance 0.41

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