INT54037

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Context Info
Confidence 0.07
First Reported 1994
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
pituitary 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 66.44 Quite High
Neuropeptide 18 56.88 Quite High
Kinase C 24 48.00 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
dexamethasone 18 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 66 89.20 High High
Volume Depletion And Dehydration 4 86.16 High High
Hypoglycemia 5 67.72 Quite High
Neuroblastoma 4 27.32 Quite Low
Cancer 6 6.32 Low Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Hyponatremia 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that the Fos/Jun family proteins mediate the rapid transcriptional induction of the vasopressin gene by extracellular stimuli.
Positive_regulation (mediate) of Positive_regulation (induction) of vasopressin gene
1) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.26 Pain Relevance 0
perceives the osmotic stimuli, would only the above candidate members generate the osmotic induction of the vasopressin gene?
Positive_regulation (generate) of Positive_regulation (induction) of vasopressin gene
2) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.14 Pain Relevance 0.03
While moderate increase of CRH output is important for stimulation of POMC transcription, the increase of the VP:CRH secretion ratio appears to be important in maintaining the secretory capacity of the pituitary corticotroph during chronic stimulation.
Spec (appears) Positive_regulation (important) of Positive_regulation (increase) of VP in pituitary
3) Confidence 0.03 Published 1994 Journal Front Neuroendocrinol Section Abstract Doc Link 7895891 Disease Relevance 0.60 Pain Relevance 0.07

General Comments

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