INT54044

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.54
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDA) cell differentiation (EDA) signal transduction (EDA)
extracellular region (EDA) plasma membrane (EDA) cytoskeleton (EDA)
Anatomy Link Frequency
joint 1
body 1
EDA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 113 99.78 Very High Very High Very High
rheumatoid arthritis 5 99.70 Very High Very High Very High
Etanercept 27 98.86 Very High Very High Very High
dorsal root ganglion 46 98.32 Very High Very High Very High
Pain 20 96.28 Very High Very High Very High
Hyperalgesia 24 71.60 Quite High
Arthritis 21 50.48 Quite High
imagery 1 45.60 Quite Low
anesthesia 6 34.64 Quite Low
cva 6 34.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 92 99.78 Very High Very High Very High
Rheumatoid Arthritis 5 99.70 Very High Very High Very High
Ganglion Cysts 46 98.32 Very High Very High Very High
Cirrhosis 7 97.72 Very High Very High Very High
Arthralgia 1 96.52 Very High Very High Very High
Syndrome 11 96.16 Very High Very High Very High
Polymyositis 1 95.64 Very High Very High Very High
Systemic Lupus Erythematosus 1 94.96 High High
Pneumonia 20 88.72 High High
Nervous System Injury 8 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patients with rheumatoid arthritis showed a high level of EDA(+) FN in their plasma, and the EDA(+) FN level in plasma corresponded with changes in joint pain.
Negative_regulation (level) of EDA in joint associated with pain, arthralgia and rheumatoid arthritis
1) Confidence 0.42 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.48 Pain Relevance 0.19
In addition to the reduced mortality, there was a reduction in the severity of histological signs of inflammation including recruitment of ED-1 positive cells in the BDL rats treated with GC before the LPS treatment.
Negative_regulation (recruitment) of ED-1 associated with inflammation
2) Confidence 0.41 Published 2008 Journal Respir Res Section Body Doc Link PMC2584635 Disease Relevance 0.25 Pain Relevance 0.09
Similar to previous studies, we also found recruitment of ED-1 positive PIMs in BDL rats.
Negative_regulation (recruitment) of ED-1
3) Confidence 0.41 Published 2008 Journal Respir Res Section Body Doc Link PMC2584635 Disease Relevance 0.56 Pain Relevance 0.09
Immunohistochemistry showed that TSA decreased the degree of staining for type I collagen in the cell cytoplasm as well as deposition of fibronectin EDA domain in the cell layer (Figure 1C).


Negative_regulation (deposition) of EDA
4) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
Waist circumference decreased in the HED, VLCHP and LCMP after 14 weeks (P < 0.001 for all groups, respectively).
Negative_regulation (decreased) of HED
5) Confidence 0.13 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0 Pain Relevance 0
After 10 weeks, those participants who restricted caloric intake and exercised experienced a significantly greater loss of body mass than HED, ND and CON (P < 0.01; Figure 3).
Negative_regulation (loss) of HED in body
6) Confidence 0.13 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0 Pain Relevance 0
Administration of etanercept before onset of CFA-induced inflammation produced a 75% reduction in ED1-positive cell numbers in the ipsilateral DRG in comparison with controls at 7 days (Fig. 5d).
Negative_regulation (reduction) of ED1 associated with dorsal root ganglion, inflammation and etanercept
7) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.24 Pain Relevance 0.77

General Comments

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