INT54052

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 25.08
Pain Relevance 14.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 5
neuronal 4
Nerve 2
liver 1
spinal cords 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 91 100.00 Very High Very High Very High
Kinase C 21 100.00 Very High Very High Very High
adenocard 18 100.00 Very High Very High Very High
Somatostatin 13 100.00 Very High Very High Very High
Nerve growth factor 11 100.00 Very High Very High Very High
qutenza 45 99.84 Very High Very High Very High
sSRI 490 99.62 Very High Very High Very High
Abeta 31 99.48 Very High Very High Very High
Morphine 24 99.20 Very High Very High Very High
Inflammation 84 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 120 100.00 Very High Very High Very High
Depression 116 100.00 Very High Very High Very High
Cancer 38 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Diabetes Mellitus 12 100.00 Very High Very High Very High
Amyloid Plaque 36 99.56 Very High Very High Very High
Aging 21 99.52 Very High Very High Very High
Disease 654 99.20 Very High Very High Very High
Injury 21 98.76 Very High Very High Very High
Encephalitis 2 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both mercury and lead increase the expression of the amyloid precursor protein; mercury also stimulates the formation of insoluble beta-amyloid, which plays a crucial role in the pathogenesis of AD and causes oxidative stress and neurotoxicity in vitro.
Gene_expression (expression) of amyloid precursor protein associated with stress, drug induced neurotoxicity, alzheimer's dementia and disease
1) Confidence 0.78 Published 2006 Journal Rev Environ Health Section Abstract Doc Link 16898674 Disease Relevance 1.30 Pain Relevance 0.18
The major purpose of the present pilot study was to determine whether the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to rats can alter the expression and processing of amyloid precursor protein (APP), the central molecule in the proposed pathomechanism of Alzheimer's disease.
Gene_expression (expression) of APP associated with alzheimer's dementia, disease and morphine
2) Confidence 0.78 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.29 Pain Relevance 0.39
The major purpose of the present pilot study was to determine whether the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to rats can alter the expression and processing of amyloid precursor protein (APP), the central molecule in the proposed pathomechanism of Alzheimer's disease.
Gene_expression (expression) of amyloid precursor protein associated with alzheimer's dementia, disease and morphine
3) Confidence 0.78 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.29 Pain Relevance 0.39
These results indicate that the chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of action, i.e. by altering the APP expression and processing in the brain.
Gene_expression (expression) of APP in brain associated with morphine
4) Confidence 0.78 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.22 Pain Relevance 0.40
MDMA treatment significantly decreased the production of APP in the cytosolic fraction of the brain cortex.
Gene_expression (production) of APP in cortex
5) Confidence 0.78 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.27 Pain Relevance 0.40
In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed.
Gene_expression (expression) of APP in spinal
6) Confidence 0.77 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.48 Pain Relevance 0
To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury.
Spec (investigated) Gene_expression (expression) of APP in motor neuron associated with aging, injury and alzheimer's dementia
7) Confidence 0.77 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury.
Gene_expression (expression) of APP in spinal cords associated with injury
8) Confidence 0.77 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Gene_expression (production) of APP associated with morphine
9) Confidence 0.67 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.41
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Gene_expression (production) of APP associated with morphine
10) Confidence 0.67 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.42
For depression and all health variables (except diabetes) there was a much higher reporting of APP among those with a disease than those without, even though there were no statistically significant differences in NO2-levels between the groups.
Gene_expression (depression) of APP associated with depression, diabetes mellitus and disease
11) Confidence 0.67 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.39 Pain Relevance 0.05
Activated microglia surrounded immunopositive amyloid beta-protein deposits, but this response was significantly attenuated in animals receiving either concurrent i.c.v. or subcutaneous (s.c.) treatment with indomethacin.
Gene_expression (attenuated) of amyloid beta-protein in microglia associated with alzheimer's dementia
12) Confidence 0.67 Published 1998 Journal Neurobiol. Aging Section Abstract Doc Link 9661994 Disease Relevance 1.09 Pain Relevance 0.23
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Gene_expression (expression) of APP-CTs in neuronal associated with alzheimer's dementia and abeta
13) Confidence 0.67 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.97 Pain Relevance 0.64
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Gene_expression (expression) of APP in neuronal associated with alzheimer's dementia and abeta
14) Confidence 0.67 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.97 Pain Relevance 0.63
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Gene_expression (expression) of amyloid precursor protein in neuronal associated with alzheimer's dementia and abeta
15) Confidence 0.67 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.96 Pain Relevance 0.63
We found that mefenamic acid attenuates the neurotoxicities induced by amyloid beta peptide (Abeta)(1-42) treatment and the expression of a Swedish double mutation (KM595/596NL) of amyloid precursor protein (Swe-APP) or the C-terminal fragments of APP (APP-CTs) in neuronal cells.
Gene_expression (expression) of APP in neuronal associated with alzheimer's dementia and abeta
16) Confidence 0.67 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.97 Pain Relevance 0.63
In this study, the effects of capsaicin on the processing of amyloid precursor protein (APP) were investigated in an in vivo model.
Gene_expression (processing) of APP associated with qutenza and alzheimer's dementia
17) Confidence 0.66 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.37 Pain Relevance 0.85
In this study, the effects of capsaicin on the processing of amyloid precursor protein (APP) were investigated in an in vivo model.
Gene_expression (processing) of amyloid precursor protein associated with qutenza and alzheimer's dementia
18) Confidence 0.66 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.37 Pain Relevance 0.85
The APP mRNA and PKC and BACE protein levels were unchanged after capsaicin treatment.
Gene_expression (levels) of APP mRNA associated with kinase c and qutenza
19) Confidence 0.66 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.32 Pain Relevance 0.92
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Gene_expression (levels) of APP in brain
20) Confidence 0.60 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.37 Pain Relevance 0.21

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