INT54054

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 21
Disease Relevance 10.89
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
heart 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 9 99.36 Very High Very High Very High
Fibrositis 108 98.92 Very High Very High Very High
depression 271 98.84 Very High Very High Very High
Kinase C 5 98.08 Very High Very High Very High
nMDA receptor 18 84.76 Quite High
Glutamate 17 82.08 Quite High
bradykinin 1 80.40 Quite High
Inflammation 10 77.32 Quite High
cytokine 1 76.76 Quite High
Neurotransmitter 2 66.80 Quite High
Disease Link Frequency Relevance Heat
Asthma 198 100.00 Very High Very High Very High
Osteoporosis 108 100.00 Very High Very High Very High
Coronary Artery Disease 108 100.00 Very High Very High Very High
Diabetes Mellitus 144 98.92 Very High Very High Very High
Sleep Disorders 108 98.92 Very High Very High Very High
Depression 271 98.84 Very High Very High Very High
Pulmonary Disease 90 98.64 Very High Very High Very High
Disease 519 96.04 Very High Very High Very High
Chronic Disease 216 92.44 High High
Respiratory Disease 108 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The new variables were all significantly associated with APP, indicating that dwelling factors (type of dwelling, damp, draughts or cold in the home and other forms of poor indoor climate) and depression were important for APP.
APP Binding (associated) of associated with depression
1) Confidence 0.48 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.53 Pain Relevance 0.13
This is largely due to the fact that none of the health variables were significantly associated with GIS-modeled levels of NO2, but they were associated with APP.
APP Binding (associated) of
2) Confidence 0.48 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 1.34 Pain Relevance 0.18
Table 2 shows results from multivariate logistic regression analysis with associations between asthma and APP, adjusted for all other variables in the model.
APP Binding (associations) of associated with asthma
3) Confidence 0.42 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.37 Pain Relevance 0.03
In the initial model, NO2 was strongly associated with APP, with more than five times as big probability for APP among those living in the quintiles with the highest NO2 levels compared to those with the least.
APP Binding (associated) of
4) Confidence 0.37 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.34 Pain Relevance 0.03
Capsaicin enhanced the level of membrane-bound APP 1.7-fold.
APP Binding (bound) of associated with qutenza
5) Confidence 0.36 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.32 Pain Relevance 0.91
These variables were independently associated with APP, and they did not attenuate any other associations except the health variables.
APP Binding (associated) of
6) Confidence 0.36 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.09 Pain Relevance 0.04
Similarly, logistic regression analyses where health variables were treated as outcomes, showed that APP was significantly associated with all outcomes (except diabetes), whereas NO2 was not associated with any health outcomes (not shown in tables).


APP Binding (associated) of associated with diabetes mellitus
7) Confidence 0.36 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.78 Pain Relevance 0.08
Still, asthma, COPD, fibromyalgia and self reported poor health were all significantly associated with APP.
APP Binding (associated) of associated with asthma, pulmonary disease and fibrositis
8) Confidence 0.36 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 1.03 Pain Relevance 0.15
We identified several other factors that were independently associated with APP, but not with NO2.Interestingly, we found that the exclusion of some of the dwelling factors led to increasingly stronger associations between health variables and APP, which indicates that APP does not only reflect air pollution in the local area, but may also reflect air quality in the home itself.
APP Binding (associations) of
9) Confidence 0.36 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.14 Pain Relevance 0.04
We identified several other factors that were independently associated with APP, but not with NO2.Interestingly, we found that the exclusion of some of the dwelling factors led to increasingly stronger associations between health variables and APP, which indicates that APP does not only reflect air pollution in the local area, but may also reflect air quality in the home itself.
APP Binding (associated) of
10) Confidence 0.36 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.14 Pain Relevance 0.03
The association between asthma and APP was reduced (odds ratio decreasing from approximately 1.5 to 1.3) but remained significant (p = 0.010).
APP Binding (association) of associated with asthma
11) Confidence 0.32 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.59 Pain Relevance 0.13
In the initial model, NO2 was strongly associated with APP, with more than five times as big probability for APP among those living in the quintiles with the highest NO2 levels compared to those with the least.
APP Binding (associated) of
12) Confidence 0.32 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.34 Pain Relevance 0.03
There were also independent associations between other variables (age, employment status and season of examination) and APP.
APP Binding (associations) of
13) Confidence 0.32 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.28 Pain Relevance 0.03
In the full model, where self reported pollution due to wood or oil heating, factory etc., dwelling conditions and depression were included, there were some reductions in the previous significant estimates (employment status was no longer significant), but the associations for quintiles of NO2 and APP were still strong, although slightly reduced.
APP Binding (associations) of associated with depression
14) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.51 Pain Relevance 0.12
If health is associated with APP, and not NO2, we then believe it indicates an over-reporting of air pollution among people with a disease.
APP Binding (associated) of associated with disease
15) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.33 Pain Relevance 0.03
Another possibility that we doubt, is that the associations between health variables and APP reflect causal air pollution effects on health.
APP Binding (associations) of
16) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 1.31 Pain Relevance 0.15
Estimates based on season showed that spring and summer were significantly stronger associated with APP than winter.
APP Binding (associated) of
17) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.25 Pain Relevance 0.04
The purpose of this was to explore whether health was associated differently with APP and NO2.
APP Spec (whether) Binding (associated) of
18) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.46 Pain Relevance 0.06
Independent associations were found between asthma, chronic obstructive pulmonary disease, fibromyalgia and self reported poor health; and APP, whereas independent associations between coronary heart disease and osteoporosis and APP were conditional on the presence of either self reported pollution due to wood or oil heating, factory etc., dwelling conditions or depression.
APP Binding (associations) of in heart associated with asthma, coronary artery disease, pulmonary disease, depression, osteoporosis and fibrositis
19) Confidence 0.31 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 1.12 Pain Relevance 0.16
Concomitantly, their activation decreases the formation of both secreted soluble beta A4 and of endosomal-lysosomal C-terminal APP derivatives.
APP Binding (formation) of
20) Confidence 0.28 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.40 Pain Relevance 0.18

General Comments

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