INT54055

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1994
Last Reported 2007
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 4.04
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 4
plaque 2
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.62 Very High Very High Very High
sSRI 192 99.60 Very High Very High Very High
Hippocampus 24 93.48 High High
Opioid 5 84.80 Quite High
Kinase C 1 79.20 Quite High
depression 20 67.04 Quite High
bradykinin 1 63.48 Quite High
Neurotransmitter 3 56.68 Quite High
tetrodotoxin 1 53.56 Quite High
Serotonin 28 52.00 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 28 100.00 Very High Very High Very High
Amyloid Plaque 10 99.56 Very High Very High Very High
Disease 215 98.96 Very High Very High Very High
Neurodegenerative Disease 22 96.72 Very High Very High Very High
Cognitive Disorder 129 93.04 High High
Brain Injury 4 77.32 Quite High
Depression 30 67.04 Quite High
Apoptosis 10 64.96 Quite High
Parkinson's Disease 4 44.00 Quite Low
Cognition Disorders 4 42.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of action, i.e. by altering the APP expression and processing in the brain.
Regulation (altering) of Gene_expression (expression) of APP in brain associated with morphine
1) Confidence 0.62 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.22 Pain Relevance 0.40
The major purpose of the present pilot study was to determine whether the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to rats can alter the expression and processing of amyloid precursor protein (APP), the central molecule in the proposed pathomechanism of Alzheimer's disease.
Regulation (alter) of Gene_expression (expression) of APP associated with alzheimer's dementia, disease and morphine
2) Confidence 0.62 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.29 Pain Relevance 0.39
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Neg (not) Regulation (influence) of Gene_expression (production) of APP associated with morphine
3) Confidence 0.45 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.42
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Neg (not) Regulation (influence) of Gene_expression (production) of APP associated with morphine
4) Confidence 0.45 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.42
The major purpose of the present pilot study was to determine whether the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to rats can alter the expression and processing of amyloid precursor protein (APP), the central molecule in the proposed pathomechanism of Alzheimer's disease.
Regulation (alter) of Gene_expression (expression) of amyloid precursor protein associated with alzheimer's dementia, disease and morphine
5) Confidence 0.45 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.29 Pain Relevance 0.39
Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices.
Regulation (Regulation) of Gene_expression (processing) of amyloid beta-protein in brain associated with alzheimer's dementia and disease
6) Confidence 0.39 Published 1994 Journal J. Neural Transm. Suppl. Section Title Doc Link 7897393 Disease Relevance 0.48 Pain Relevance 0.15
Unlike the studies above, SSRI administration enhances secretion of entire APPs and does not specifically alter expression of the APP ectodomain segment.
Neg (not) Regulation (alter) of Gene_expression (expression) of APP associated with ssri
7) Confidence 0.25 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.62 Pain Relevance 0.24
The chemical structure of paroxetine, and not intrinsic SSRI activity, may also affect APP ectodomain expression to reduce amyloid plaque formation.
Spec (may) Regulation (affect) of Gene_expression (expression) of APP in plaque associated with ssri and amyloid plaque
8) Confidence 0.11 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2656299 Disease Relevance 1.66 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox