INT54060

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2002
Negated 1
Speculated 1
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 0.59
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
CNS 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 40 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Enkephalin 2 99.76 Very High Very High Very High
Central nervous system 8 99.48 Very High Very High Very High
Intracerebroventricular 3 93.32 High High
Morphine 2 92.48 High High
Potency 3 87.68 High High
tail-flick 1 87.00 High High
Dopamine 5 86.92 High High
Kappa opioid receptor 3 81.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 97.04 Very High Very High Very High
Urological Neuroanatomy 8 57.36 Quite High
Attention Deficit Hyperactivity Disorder 1 31.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the effect of supraspinal antisense ODN administration on delta-opioid receptor (DOR) mRNA levels in selected CNS regions, was investigated in mice.
Spec (investigated) Regulation (effect) of Transcription (levels) of delta-opioid receptor in CNS associated with central nervous system and opioid receptor
1) Confidence 0.57 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9379841 Disease Relevance 0 Pain Relevance 0.82
Supraspinal delta opioid receptor mRNA levels are not altered in [D-Ala2]deltorphin II tolerant mice.
Neg (not) Regulation (altered) of Transcription (levels) of delta opioid receptor associated with enkephalin and opioid receptor
2) Confidence 0.24 Published 1994 Journal J. Neurosci. Res. Section Title Doc Link 7897702 Disease Relevance 0 Pain Relevance 0.70
Effect of supraspinal antisense oligodeoxynucleotide treatment on delta-opioid receptor mRNA levels in mice.
Regulation (Effect) of Transcription (levels) of delta-opioid receptor associated with pain and opioid receptor
3) Confidence 0.22 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9379841 Disease Relevance 0.17 Pain Relevance 1.03
Furthermore, we show here that chronic constitutive hyperdopaminergia only affects delta-opioid receptor mRNA levels in adult.
Regulation (affects) of Transcription (levels) of delta-opioid receptor associated with opioid receptor
4) Confidence 0.20 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.41 Pain Relevance 0.63

General Comments

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