INT54062

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.05
Pain Relevance 6.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
DCs 1
brain 1
CNS 1
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 76 100.00 Very High Very High Very High
Enkephalin 5 99.76 Very High Very High Very High
Central nervous system 8 99.48 Very High Very High Very High
MU agonist 4 99.26 Very High Very High Very High
agonist 15 98.92 Very High Very High Very High
Pain 2 98.68 Very High Very High Very High
Opioid 6 97.56 Very High Very High Very High
Morphine 5 97.02 Very High Very High Very High
Intracerebroventricular 4 96.52 Very High Very High Very High
antagonist 2 92.64 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 97.04 Very High Very High Very High
INFLAMMATION 1 87.32 High High
Urological Neuroanatomy 8 57.36 Quite High
Attention Deficit Hyperactivity Disorder 2 30.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This fluorescent probe should prove useful in the study of the distribution of the delta opioid receptor.
Transcription (distribution) of delta opioid receptor associated with opioid receptor
1) Confidence 0.68 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9682822 Disease Relevance 0 Pain Relevance 0.44
In the present study, the effect of supraspinal antisense ODN administration on delta-opioid receptor (DOR) mRNA levels in selected CNS regions, was investigated in mice.
Transcription (levels) of delta-opioid receptor in CNS associated with central nervous system and opioid receptor
2) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9379841 Disease Relevance 0 Pain Relevance 0.82
Delta opioid receptor (DOR) mRNA levels were studied in mice rendered tolerant to [D-Ala2]deltorphin II by 4 days of repeated intracerebroventricular administration (10 micrograms, [tid]).
Transcription (levels) of Delta opioid receptor associated with opioid receptor and intracerebroventricular
3) Confidence 0.53 Published 1994 Journal J. Neurosci. Res. Section Abstract Doc Link 7897702 Disease Relevance 0 Pain Relevance 0.33
Supraspinal delta opioid receptor mRNA levels are not altered in [D-Ala2]deltorphin II tolerant mice.
Transcription (levels) of delta opioid receptor associated with enkephalin and opioid receptor
4) Confidence 0.46 Published 1994 Journal J. Neurosci. Res. Section Title Doc Link 7897702 Disease Relevance 0 Pain Relevance 0.69
Even if the propensity of knock-out mice to show increased rewarding properties to morphine seems to be mainly due to the substantial and further increase in hyperdopaminergic activity following drug treatment, the involvement of increased delta-opioid receptor mRNA levels in this behavior remains to be elucidated.
Transcription (levels) of delta-opioid receptor associated with targeted disruption, opioid receptor and morphine
5) Confidence 0.46 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.38 Pain Relevance 0.53
Effect of supraspinal antisense oligodeoxynucleotide treatment on delta-opioid receptor mRNA levels in mice.
Transcription (levels) of delta-opioid receptor associated with pain and opioid receptor
6) Confidence 0.43 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9379841 Disease Relevance 0.17 Pain Relevance 1.03
Furthermore, we show here that chronic constitutive hyperdopaminergia only affects delta-opioid receptor mRNA levels in adult.
Transcription (levels) of delta-opioid receptor associated with opioid receptor
7) Confidence 0.40 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.41 Pain Relevance 0.63
We found that the delta opioid receptor (DOR) mRNA was expressed at low level in bone marrow-derived immature DCs and up-regulated upon DC maturation.
Transcription (expressed) of delta opioid receptor in DCs associated with opioid receptor
8) Confidence 0.32 Published 2008 Journal J. Neuroimmunol. Section Abstract Doc Link 18486241 Disease Relevance 0.09 Pain Relevance 0.76
These results suggest that long-term administration of both peptide delta opioid receptor agonist (24, 48 h) and non-peptide delta opioid agonist (24 h) significantly decreased mRNA expression of delta opioid receptor and the effect of peptide agonist DPDPE seems to be stronger and last longer than that of non-peptide agonist BW373U86.
Transcription (expression) of delta opioid receptor associated with mu agonist, agonist and opioid receptor
9) Confidence 0.13 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.61
[Inhibition of the expression of delta opioid receptor mRNA by long-term exposure of NG-108-15 cell line to delta opioid agonists].
Transcription (expression) of delta opioid receptor associated with mu agonist and opioid receptor
10) Confidence 0.09 Published 1998 Journal Sheng Li Xue Bao Section Title Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.55
The novel delta-opioid receptor transcript is expressed in mouse brain and contains a 243 bp insertion.
Transcription (expressed) of delta-opioid receptor in brain associated with opioid receptor
11) Confidence 0.01 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332727 Disease Relevance 0 Pain Relevance 0.25

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