INT54064

Context Info Confidence 0.66 First Reported 1993 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 5.49 Pain Relevance 6.55

Anatomy Link Frequency blood 1 brain 1 frontal cortex 1 Slc6a2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 23 99.76 agonist 14 99.36 depression 21 98.92 Dopamine 121 98.84 anesthesia 8 98.60 spastic colon 21 97.92 fluoxetine 3 97.44 Desipramine 35 96.84 cerebral cortex 2 83.92 Catecholamine 10 83.32

Disease Link Frequency Relevance Heat Urological Neuroanatomy 3 99.38 Depression 34 98.92 Stress 25 98.86 Congenital Anomalies 4 98.60 Targeted Disruption 2 98.22 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 15 97.92 Tourette's Syndrome 8 96.32 Attention Deficit Hyperactivity Disorder 1 95.52 Tics 1 91.36 Functional Bowel Disorder 6 82.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the 'saline' group, the clonidine/saline animals had significantly less NET mRNA expression compared to the saline/saline animals.

Gene_expression (expression) of NET associated with clonidine

1) Confidence 0.66 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.30

In both treatment groups, administration of yohimbine did not alter the expression of NET mRNA compared to the appropriate control animals.

Gene_expression (expression) of NET

2) Confidence 0.66 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.45

However, the G proteins, alpha(2A)-AR, and NET expression changed differently in AS and CAS rats.

Gene_expression (expression) of NET associated with stress

3) Confidence 0.46 Published 2008 Journal Transl Res Section Abstract Doc Link 19059163 Disease Relevance 0.93 Pain Relevance 0.51

Western blot analysis was used to investigate the expression of G proteins, alpha(2A)-ARs, and NET.

Spec (investigate) Gene_expression (expression) of NET

4) Confidence 0.40 Published 2008 Journal Transl Res Section Abstract Doc Link 19059163 Disease Relevance 0.93 Pain Relevance 0.54

It is conceivable that stress may induce brain G proteins, colonic alpha(2A)-ARs, and NET abnormal expression, which may be responsible for the abnormalities in IBS.

Gene_expression (expression) of NET in brain associated with stress, congenital anomalies and spastic colon

5) Confidence 0.40 Published 2008 Journal Transl Res Section Abstract Doc Link 19059163 Disease Relevance 0.81 Pain Relevance 0.54

It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression.

Gene_expression (dysfunction) of norepinephrine transporter associated with depression

6) Confidence 0.21 Published 2004 Journal Neuropsychobiology Section Abstract Doc Link 15118352 Disease Relevance 0.75 Pain Relevance 0.48

The norepinephrine transporter gene (NET) was systematically screened by single-strand conformation analysis for genetic variants, including the whole coding region and adjacent exon-intron boundaries in 43 patients with TS and 46 healthy controls.

Gene_expression (screened) of norepinephrine transporter associated with tourette's syndrome

7) Confidence 0.14 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10206236 Disease Relevance 0.68 Pain Relevance 0.15

Using NET knock-out mice, it was shown that DA uptake into frontal cortex synaptosomes is the result of NET and not DAT blockade, because a selective concentration of GBR12909 did not block DA uptake into frontal cortex synaptosomes from NET knock-out mice [67].

Gene_expression (blockade) of NET in frontal cortex associated with targeted disruption, dopamine and urological neuroanatomy

8) Confidence 0.10 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.47 Pain Relevance 1.05

Hemodynamic parameters and blood levels of norepinephrine (NEP) and epinephrine (EP) were measured three minutes (S1) and ten minutes (S2) after tracheal intubation.

Gene_expression (levels) of norepinephrine in blood

9) Confidence 0.01 Published 1993 Journal Masui Section Abstract Doc Link 7901441 Disease Relevance 0 Pain Relevance 0.53

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