INT54065

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1994
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.68
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Slc6a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 42 99.82 Very High Very High Very High
Clonidine 28 99.76 Very High Very High Very High
agonist 7 99.36 Very High Very High Very High
antagonist 6 94.20 High High
Disease Link Frequency Relevance Heat
Tourette's Syndrome 8 96.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 95.52 Very High Very High Very High
Tics 1 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies are needed to clarify the mechanism of the DMI-induced increase in NET mRNA and to correlate changes in NET mRNA with transporter expression at the synaptic membrane.
Positive_regulation (increase) of NET associated with desipramine
1) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.15
These findings suggest that the DMI-induced increase in NET mRNA is not mediated via alpha 2 receptors for, although clonidine attenuates DMI's effect, there is no reciprocal enhancement with the alpha 2 antagonist yohimbine.
Positive_regulation (increase) of NET associated with desipramine, antagonist and clonidine
2) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.45
In the 'DMI' group an attentuation of the DMI-induced increase in NET mRNA was observed in the clonidine/DMI animals compared to the saline/DMI animals.
Positive_regulation (increase) of NET associated with desipramine and clonidine
3) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7898321 Disease Relevance 0 Pain Relevance 1.41
The norepinephrine transporter gene (NET) was systematically screened by single-strand conformation analysis for genetic variants, including the whole coding region and adjacent exon-intron boundaries in 43 patients with TS and 46 healthy controls.
Positive_regulation (screened) of norepinephrine transporter associated with tourette's syndrome
4) Confidence 0.10 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10206236 Disease Relevance 0.68 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox