INT54077

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 62
Total Number 63
Disease Relevance 23.17
Pain Relevance 16.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 11
neurons 4
nerve 4
CeA 2
bladder 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 1722 100.00 Very High Very High Very High
Neuropeptide 158 100.00 Very High Very High Very High
Calcitonin gene-related peptide 65 100.00 Very High Very High Very High
Enkephalin 31 100.00 Very High Very High Very High
Cholecystokinin 5 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
primary afferent fibers 21 99.84 Very High Very High Very High
Dorsal horn 39 99.82 Very High Very High Very High
substance P 20 99.60 Very High Very High Very High
Inflammation 33 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cystitis 30 99.96 Very High Very High Very High
Overactive Bladder 12 99.80 Very High Very High Very High
Injury 23 99.62 Very High Very High Very High
INFLAMMATION 27 99.48 Very High Very High Very High
Nervous System Injury 9 99.42 Very High Very High Very High
Anxiety Disorder 827 99.36 Very High Very High Very High
Shock 1136 99.24 Very High Very High Very High
Ganglion Cysts 41 98.92 Very High Very High Very High
Fever 38 97.84 Very High Very High Very High
Neuropathic Pain 8 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synthesis of PACAP in intrinsic neurons was confirmed by in situ hybridization.
Gene_expression (synthesis) of PACAP in intrinsic neurons
1) Confidence 0.78 Published 1998 Journal Cell Tissue Res. Section Abstract Doc Link 9394044 Disease Relevance 0 Pain Relevance 0.18
The expression of pituitary adenylate cyclase activating polypeptide (PACAP) was studied in the gastrointestinal tract (GI-tract) of normal rats using radioimmunoassay, chromatography, immunocytochemistry, and in situ hybridization.
Gene_expression (expression) of pituitary adenylate cyclase activating polypeptide in pituitary
2) Confidence 0.78 Published 1998 Journal Cell Tissue Res. Section Abstract Doc Link 9394044 Disease Relevance 0 Pain Relevance 0.07
The expression of pituitary adenylate cyclase activating polypeptide (PACAP) was studied in the gastrointestinal tract (GI-tract) of normal rats using radioimmunoassay, chromatography, immunocytochemistry, and in situ hybridization.
Gene_expression (expression) of PACAP in pituitary
3) Confidence 0.78 Published 1998 Journal Cell Tissue Res. Section Abstract Doc Link 9394044 Disease Relevance 0 Pain Relevance 0.07
The synthesis of PACAP in neurons of the paracervical ganglia was confirmed by in situ hybridization histochemistry with a digoxigenin-labelled cRNA probe.
Gene_expression (synthesis) of PACAP in neurons
4) Confidence 0.78 Published 1996 Journal Neuroscience Section Abstract Doc Link 8809823 Disease Relevance 0.34 Pain Relevance 0.14
In view of the presence of PACAP-immunoreactive nerve fibres in the superficial layers of the dorsal horn and the expression of PACAP in the small sized neurons in the dorsal root ganglia, the findings suggest that PACAP is released into the artificial cerebrospinal fluid from C-fibres in the spinal cord.
Gene_expression (expression) of PACAP in cerebrospinal fluid associated with c fibre, dorsal horn and spinal cord
5) Confidence 0.78 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178350 Disease Relevance 0 Pain Relevance 0.74
We conclude that PACAP is synthesized in a subpopulation of neurons of sensory ganglia in the rat.
Gene_expression (synthesized) of PACAP in neurons
6) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898655 Disease Relevance 0.43 Pain Relevance 0.49
Since PACAP belongs to a large family of chemically related neuropeptides, we have, in the present study, tried to establish the synthesis of PACAP in neurons of sensory ganglia, using in situ hybridization with a 35S-labelled oligonucleotide probe complementary to PACAP mRNA.
Gene_expression (synthesis) of PACAP in ganglia associated with neuropeptide
7) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898655 Disease Relevance 0.07 Pain Relevance 0.24
The expression of PACAP was compared to that of calcitonin gene-related peptide (CGRP) using a radiolabelled CGRP oligonucleotide probe.
Gene_expression (expression) of PACAP associated with calcitonin gene-related peptide
8) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898655 Disease Relevance 0.09 Pain Relevance 0.33
Expression of PACAP was seen in a small subpopulation of cells expressing CGRP.
Gene_expression (Expression) of PACAP associated with calcitonin gene-related peptide
9) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898655 Disease Relevance 0.40 Pain Relevance 0.49
In dorsal root ganglia, cells expressing PACAP constituted c. 10% and those expressing CGRP 46% of the total number of nerve cell bodies.
Gene_expression (expressing) of PACAP in dorsal root ganglia associated with calcitonin gene-related peptide
10) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898655 Disease Relevance 0.37 Pain Relevance 0.48
In control Wistar rats, PACAP immunoreactivity was expressed in fibers in the superficial dorsal horn at all segmental levels examined (L1, L2, and L4-S1).
Gene_expression (expressed) of PACAP in dorsal horn associated with dorsal horn
11) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.42 Pain Relevance 0.05
These studies examined changes in the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in micturition reflex pathways after chronic cystitis induced by cyclophosphamide (CYP).
Gene_expression (expression) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with cystitis and overactive bladder
12) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.39 Pain Relevance 0.04
These studies examined changes in the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in micturition reflex pathways after chronic cystitis induced by cyclophosphamide (CYP).
Gene_expression (expression) of PACAP in pituitary associated with cystitis and overactive bladder
13) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.40 Pain Relevance 0.04
After chronic cystitis, PACAP immunoreactivity in cells in the L1, L2, L6, and S1 DRG increased significantly (P </= 0.0001), and the percentage of bladder afferent cells expressing PACAP immunoreactivity also increased significantly (P </= 0.0001; 70-85%).
Gene_expression (expressing) of PACAP in bladder associated with cystitis
14) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10754506 Disease Relevance 0.67 Pain Relevance 0.30
densities of specific PACAP receptor (PAC1-R) expression were detected in
Gene_expression (expression) of PACAP
15) Confidence 0.75 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.48 Pain Relevance 0.39
PACAP was also expressed in a few adrenaline chromaffin cells after immunological removal of the preganglionic innervation, suggesting an additional, hormonal role.
Gene_expression (expressed) of PACAP in chromaffin cells
16) Confidence 0.74 Published 1996 Journal Neuroreport Section Abstract Doc Link 9051799 Disease Relevance 0 Pain Relevance 0.55
Pituitary adenylate cyclase activating peptide (PACAP) is expressed in a population of capsaicin-sensitive primary sensory neurons of small to medium size in the rat.
Gene_expression (expressed) of PACAP in primary sensory neurons associated with qutenza
17) Confidence 0.73 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.16 Pain Relevance 0.28
In the present report we have examined the effect of sciatic nerve injury (unilateral transection) on PACAP expression (immunocytochemistry, radioimmunoassay, in situ hybridization and northern blot analysis) in dorsal root ganglia at the lumbar level and on immunoreactive PACAP in the spinal cord and in the sciatic nerve stump.
Gene_expression (expression) of PACAP in spinal cord associated with nervous system injury, sciatic nerve and spinal cord
18) Confidence 0.73 Published 1996 Journal Neuroscience Section Abstract Doc Link 8895878 Disease Relevance 0.17 Pain Relevance 0.34
Seven days following injury, the incidence of expression of the neuropeptides galanin and pituitary adenylate cyclase-activating polypeptide (PACAP) was increased in L5 sensory neurons ipsilateral to the injury from 12% to 60% and 16% to 37% respectively, in addition to an increased level of expression.
Gene_expression (expression) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with injury and neuropeptide
19) Confidence 0.71 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.20 Pain Relevance 0.98
Seven days following injury, the incidence of expression of the neuropeptides galanin and pituitary adenylate cyclase-activating polypeptide (PACAP) was increased in L5 sensory neurons ipsilateral to the injury from 12% to 60% and 16% to 37% respectively, in addition to an increased level of expression.
Gene_expression (expression) of PACAP in pituitary associated with injury and neuropeptide
20) Confidence 0.71 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.20 Pain Relevance 0.98

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