INT5408

Context Info Confidence 0.73 First Reported 1992 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 30 Total Number 32 Disease Relevance 12.10 Pain Relevance 3.84

transport (Alb) enzyme binding (Alb) DNA binding (Alb) protein complex (Alb) response to stress (Alb) cytoplasm (Alb)

Anatomy Link Frequency plasma 4 hepatocytes 2 fibroblast 2 urine 2 liver 1 Alb (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 345 99.88 Paracetamol 15 99.20 Kinase C 26 99.08 lidocaine 1 98.96 antagonist 15 98.04 Glutamate 5 96.48 ketamine 3 95.52 ischemia 21 95.12 anesthesia 20 94.80 Bile 28 90.08

Disease Link Frequency Relevance Heat INFLAMMATION 341 99.88 Hepatotoxicity 5 99.62 Renal Disease 235 99.50 Adhesions 108 99.22 Diabetic Retinopathy 5 99.06 Aids-related Complex 294 99.04 Alzheimer's Dementia 15 99.04 Disease 102 98.52 Necrosis 20 97.52 Disorders Of Creatine Metabolism 7 96.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Diabetic patients were divided into 2 groups according to the following diagnostic criteria: 1) nephropathy cases, i.e., patients with diabetic retinopathy and overt nephropathy, indicated by a urinary albumin excretion rate (AER) ?

Localization (excretion) of albumin associated with diabetes mellitus, renal disease and diabetic retinopathy

1) Confidence 0.73 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 0.96 Pain Relevance 0

Plasma was analysed for the following parameters: total protein, total bilirubin, creatine kinase activity, aspartate aminotransferase activity, cholesterol, creatinine, albumin, alkaline phosphatase activity, gamma-glutamyl transferase activity, triglycerides and glutamate dehydrogenase using a Konelab clinical chemistry analyzer (Thermo Scientific, Waltham, MA).

Localization (creatinine) of albumin in Plasma associated with glutamate

2) Confidence 0.73 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.05

All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).

Neg (blocked) Localization (blocked) of serum albumin in fibroblast

3) Confidence 0.73 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.13 Pain Relevance 0.07

All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).

Localization (blocking) of serum albumin in fibroblast

4) Confidence 0.73 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.13 Pain Relevance 0.06

ES cell-derived hepatocytes expressed liver-specific genes, secreted albumin and metabolized ammonia, lidocaine and diazepam.

Localization (secreted) of albumin in hepatocytes associated with lidocaine

5) Confidence 0.69 Published 2006 Journal Nat. Biotechnol. Section Abstract Doc Link 17086173 Disease Relevance 0.15 Pain Relevance 0.10

The cells retained the characteristics of differentiated hepatocytes, but the functional characteristics such as albumin secretion, ureogenesis, and glyconeogenesis decreased gradually as the passages progressed beyond 200 population doublings (PDs).

Localization (secretion) of albumin in hepatocytes

6) Confidence 0.66 Published 2008 Journal Transplant. Proc. Section Abstract Doc Link 18374145 Disease Relevance 0.15 Pain Relevance 0.07

It also serves an endocrine function by secreting albumin (Alb), most coagulation factors, several plasma carrier proteins, and lipids into the blood.

Localization (secreting) of albumin in plasma

7) Confidence 0.63 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0.08

It also serves an endocrine function by secreting albumin (Alb), most coagulation factors, several plasma carrier proteins, and lipids into the blood.

Localization (secreting) of Alb in plasma

8) Confidence 0.63 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0.08

In addition, lymphatic drainage was assessed from the disappearance of instilled 125I-albumin from the peritoneal cavity and from the appearance of intraperitoneally administered 125I-albumin in the bloodstream and compared with data from the cannulated preparations.

Localization (appearance) of 125I-albumin in peritoneal cavity

9) Confidence 0.58 Published 1992 Journal Blood Purif. Section Abstract Doc Link 1308678 Disease Relevance 0 Pain Relevance 0.09

Urine osmolality and 24-hour excretion of fluid, Na+, K+ and albumin were not different between genotypes, but urine pH was more alkaline in PKC-beta-/- mice.

Localization (excretion) of albumin in urine

10) Confidence 0.42 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.23 Pain Relevance 0.17

Administration of corn oil alone did not cause elevation of serum SEAP (data not shown).

Localization (elevation) of serum SEAP

11) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.06 Pain Relevance 0.04

g/kg bw TCDD also caused significant elevation of serum SEAP at days 14 and 21 (Figure 2B).

Localization (elevation) of serum SEAP

12) Confidence 0.36 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0 Pain Relevance 0.03

Renal albumin excretion was not different.

Localization (excretion) of albumin

13) Confidence 0.34 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.09 Pain Relevance 0.57

In a study of rats given endotoxin by continuous infusion, fucoidin, a selectin-binding carbohydrate, blocked leukocyte adhesion but it did not significantly decrease leakage of albumin [26].

Localization (leakage) of albumin in leukocyte associated with adhesions

14) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.14 Pain Relevance 0.14

Albumin leakage was then determined as follows: ([FIout ?

Spec (determined) Localization (leakage) of Albumin

15) Confidence 0.32 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.15 Pain Relevance 0.11

In contrast to such apparently beneficial effects, 100 ppm inhaled CO induced an increase in pulmonary barrier permeability as determined by lavage fluid protein content and translocation of labelled albumin from blood to the alveolar space.

Localization (translocation) of albumin in blood

16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2903490 Disease Relevance 0.46 Pain Relevance 0.18

Albumin leakage was quantified by measuring mean fluorescence intensity, with video analysis software, of two 10 × 50 ?

Localization (leakage) of Albumin

17) Confidence 0.27 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.17 Pain Relevance 0.12

Albumin leakage

Localization (leakage) of Albumin

18) Confidence 0.27 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.26 Pain Relevance 0.14

On days 9 and 15 of the study, mice were placed in individual metabolic cages with 5% dextrose in water for an overnight collection to measure urinary albumin (ELISA Albuwell M Kit Stock no. 1011, Exocell Inc., Philadelphia, PA), creatinine (Creatinine Companion Stock no. 1012, Exocell Inc., Philadelphia, PA), the arachidonic acid metabolite 12-hydroxytetraenoic acid (12-HETE), and Cur and its metabolites by high performance liquid chromatography (HPLC).

Localization (measure) of albumin

19) Confidence 0.25 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.57 Pain Relevance 0

By 28 days, LDH and albumin had returned to baseline in all groups exposed to GMA-MS (data not shown).

Localization (returned) of albumin associated with aids-related complex

20) Confidence 0.24 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.84 Pain Relevance 0

General Comments

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