INT5409

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Context Info
Confidence 0.57
First Reported 1981
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 33
Total Number 51
Disease Relevance 29.21
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6pd) oxidoreductase activity (G6pd) nucleus (G6pd)
carbohydrate metabolic process (G6pd) cytoplasm (G6pd)
Anatomy Link Frequency
lung 2
blood 1
dorsum 1
lenses 1
RBCs 1
G6pd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 17 100.00 Very High Very High Very High
aspirin 6 99.92 Very High Very High Very High
Paracetamol 22 99.64 Very High Very High Very High
Morphine 4 98.98 Very High Very High Very High
rapifen 9 98.80 Very High Very High Very High
local anesthetic 100 97.60 Very High Very High Very High
anesthesia 85 97.00 Very High Very High Very High
algil 6 96.48 Very High Very High Very High
cINOD 14 95.96 Very High Very High Very High
Ultiva 6 95.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaemia 47 99.92 Very High Very High Very High
Purpura 19 99.90 Very High Very High Very High
Hypersensitivity 55 99.84 Very High Very High Very High
Hemolysis 19 99.84 Very High Very High Very High
Diabetes Mellitus 49 99.72 Very High Very High Very High
Splenomegaly 1 99.60 Very High Very High Very High
Methemoglobinemia 10 99.38 Very High Very High Very High
Cataract 30 99.28 Very High Very High Very High
Sickle Cell Anemia 46 99.24 Very High Very High Very High
Syndrome 53 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A rapid fluorescent spot test showed the patient to be G6PD deficient even though after a massive haemolysis, a normal phenotype would be expected as older red blood cells (RBCs) are destroyed and new ones, with normal phenotype, are produced.
Negative_regulation (deficient) of G6PD in RBCs
1) Confidence 0.57 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0.44 Pain Relevance 0.09
We also screened 31 Negro male adults with diabetes mellitus for red cell G-6-PD deficiency.
Negative_regulation (deficiency) of G-6-PD associated with diabetes mellitus
2) Confidence 0.51 Published 1992 Journal Arch. Med. Res. Section Abstract Doc Link 1308788 Disease Relevance 0.44 Pain Relevance 0.12
Administration of 800 IU/day of vitamin E to subjects with G6PD deficiency, sickle-cell anemia and beta-thalassemia has resulted in improvement of hematological parameters.
Negative_regulation (deficiency) of G6PD associated with anaemia and thalassemia
3) Confidence 0.43 Published 1989 Journal Int J Vitam Nutr Res Suppl Section Abstract Doc Link 2507707 Disease Relevance 0.98 Pain Relevance 0.28
The frequencies of G6PD deficiency, anemia, splenomegaly and tuberculosis are neighbouring at the negro without hemoglobinopathy.
Negative_regulation (deficiency) of G6PD associated with mycobacterial infection, hemoglobinopathy, splenomegaly and anaemia
4) Confidence 0.43 Published 1981 Journal Sem Hop Section Abstract Doc Link 6258231 Disease Relevance 0.40 Pain Relevance 0.07
Effects of G-6-PD deficiency, experimentally induced or genetically transmitted, on the sorbitol pathway activity.
Negative_regulation (deficiency) of G-6-PD
5) Confidence 0.43 Published 1992 Journal Arch. Med. Res. Section Title Doc Link 1308788 Disease Relevance 0.37 Pain Relevance 0.10
Finally, two diabetic individuals were G-6-PD deficient and did not show cataracts whereas cataracts were identified in six other diabetic patients.
Negative_regulation (deficient) of G-6-PD associated with diabetes mellitus and cataract
6) Confidence 0.43 Published 1992 Journal Arch. Med. Res. Section Abstract Doc Link 1308788 Disease Relevance 0.80 Pain Relevance 0.13
We have investigated the effect of G-6-PD deficiency, either experimentally induced or genetically transmitted, on the sorbitol accumulation in whole cells incubated in high glucose media and on the "sugar-cataracts" formation in a galactosemic rat model.
Spec (investigated) Negative_regulation (deficiency) of G-6-PD associated with cataract
7) Confidence 0.43 Published 1992 Journal Arch. Med. Res. Section Abstract Doc Link 1308788 Disease Relevance 0.42 Pain Relevance 0.11
The consequence of such practice is demonstrated by this case and serves to remind that acute haemolysis is a real and potentially fatal consequence when primaquine is administered to patients with G6PD deficiency.
Negative_regulation (deficiency) of G6PD
8) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0.12 Pain Relevance 0
The medication instructions had not been given in a language understood by the patient and he had not been tested for G6PD deficiency.
Negative_regulation (deficiency) of G6PD
9) Confidence 0.42 Published 2010 Journal Malar J Section Abstract Doc Link PMC3018394 Disease Relevance 0.32 Pain Relevance 0
This potentially fatal clinical syndrome can be avoided if patients are tested for G6PD deficiency before the administration of primaquine.
Negative_regulation (deficiency) of G6PD associated with syndrome
10) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.22 Pain Relevance 0.17
Therefore testing for G6PD deficiency before administration of primaquine should be mandatory in areas where the deficiency is found to be common.
Negative_regulation (deficiency) of G6PD
11) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0.32 Pain Relevance 0
There are many different genotypes of G6PD deficiency.
Negative_regulation (deficiency) of G6PD
12) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0.20 Pain Relevance 0
The most reliable way to detect G6PD deficiency is by DNA analysis, but a diagnosis of G6PD deficiency can also be made by a rapid fluorescent spot test [7].
Negative_regulation (deficiency) of G6PD
13) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.09 Pain Relevance 0.16
In areas where P. vivax exists, patients should be tested for G6PD deficiency and adequately informed before administration of primaquine.



Negative_regulation (deficiency) of G6PD
14) Confidence 0.42 Published 2010 Journal Malar J Section Abstract Doc Link PMC3018394 Disease Relevance 0.24 Pain Relevance 0
To reduce the risk of haemolysis, the WHO currently makes the following recommendations: In patients with mild G6PD deficiency i.e. those patients with a history of tolerability of primaquine, the WHO suggests using an intermittent primaquine regimen of 0.75 mg base/kg once a week for eight weeks [4].
Negative_regulation (deficiency) of G6PD
15) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0 Pain Relevance 0
Patients with the inherited sex-linked deficiency of glucose-6-phosphate dehydrogenase (G6PD), have an increased susceptibility to acute intravascular haemolysis when treated with oxidant drugs such as primaquine [6].
Negative_regulation (deficiency) of G6PD
16) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.63 Pain Relevance 0.17
Patients with the inherited sex-linked deficiency of glucose-6-phosphate dehydrogenase (G6PD), have an increased susceptibility to acute intravascular haemolysis when treated with oxidant drugs such as primaquine [6].
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase
17) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.62 Pain Relevance 0.17
The most reliable way to detect G6PD deficiency is by DNA analysis, but a diagnosis of G6PD deficiency can also be made by a rapid fluorescent spot test [7].
Negative_regulation (deficiency) of G6PD
18) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.12 Pain Relevance 0.17
Until these aspects of G6PD deficiency are better understood and the characterization of other deficient mutations in the local population is established (including their spatial distribution and the phenotypes associated with), in the absence of confirmed G6PD-normal status or evidence of previous primaquine tolerability, primaquine should not be administered.
Negative_regulation (deficiency) of G6PD
19) Confidence 0.42 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0 Pain Relevance 0
This potentially fatal clinical syndrome can be avoided if patients are tested for G6PD deficiency and adequately informed before being treated.


Negative_regulation (deficiency) of G6PD associated with syndrome
20) Confidence 0.42 Published 2010 Journal Malar J Section Abstract Doc Link PMC3018394 Disease Relevance 0.35 Pain Relevance 0

General Comments

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