INT541

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Context Info
Confidence 0.67
First Reported 1975
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 33
Disease Relevance 28.56
Pain Relevance 12.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
CSF 6
optic 3
band 3
cleavage 1
eosinophil 1
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 107 100.00 Very High Very High Very High
metalloproteinase 46 100.00 Very High Very High Very High
Neuritis 42 99.90 Very High Very High Very High
Multiple sclerosis 150 99.48 Very High Very High Very High
Demyelination 6 98.92 Very High Very High Very High
Inflammation 71 98.88 Very High Very High Very High
imagery 20 97.60 Very High Very High Very High
Peripheral nervous system 1 95.40 Very High Very High Very High
anesthesia 4 94.52 High High
Pain 7 91.36 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 177 100.00 Very High Very High Very High
Optic Neuritis 39 99.90 Very High Very High Very High
Disease 69 99.84 Very High Very High Very High
Recurrence 17 99.82 Very High Very High Very High
Cancer 52 99.72 Very High Very High Very High
Demyelinating Disease 163 99.48 Very High Very High Very High
Leukocytosis 8 99.24 Very High Very High Very High
INFLAMMATION 71 98.88 Very High Very High Very High
Disseminated Intravascular Coagulation 1 98.60 Very High Very High Very High
Asthma 22 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunological tests revealed elevation of the level of myelin basic protein antibodies, which correlated with the degree of neurological disturbances and the duration of the disease.
Positive_regulation (elevation) of myelin basic protein associated with disease
1) Confidence 0.67 Published 2006 Journal Klin Med (Mosk) Section Abstract Doc Link 16512396 Disease Relevance 1.23 Pain Relevance 0.51
The level of CSF MBPLM rarely is elevated in optic neuritis.
Positive_regulation (elevated) of MBP in CSF associated with optic neuritis and neuritis
2) Confidence 0.67 Published 1998 Journal Mult. Scler. Section Abstract Doc Link 9532587 Disease Relevance 0.51 Pain Relevance 0.25
In 53 optic neuritis patients free anti-MBP was elevated in 47 and in 6 of these 47 patients bound anti-MBP was also increased.
Positive_regulation (elevated) of anti-MBP in optic associated with optic neuritis and neuritis
3) Confidence 0.60 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 0.97 Pain Relevance 0.59
Of 173 MS patients with acute relapses 169 had increased free anti-MBP.
Positive_regulation (increased) of anti-MBP associated with multiple sclerosis and recurrence
4) Confidence 0.60 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.19 Pain Relevance 0.67
In 53 optic neuritis patients free anti-MBP was elevated in 47 and in 6 of these 47 patients bound anti-MBP was also increased.
Positive_regulation (increased) of anti-MBP in optic associated with optic neuritis and neuritis
5) Confidence 0.60 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.05 Pain Relevance 0.63
Of 87 MS patients in remission, 15 had modestly elevated anti-MBP and none had detectable anti-PLP.
Positive_regulation (elevated) of anti-MBP associated with multiple sclerosis
6) Confidence 0.60 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.18 Pain Relevance 0.65
Others have suggested a role of eosinophil-derived MBP as a cause of M2 muscarinic receptor dysfunction.
Positive_regulation (derived) of MBP in eosinophil
7) Confidence 0.50 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.27 Pain Relevance 0
The cerebrospinal fluid was clear, with normal pressure, 9 leukocytes/mm(3), and 27 mg/dL protein, but the myelin basic protein was elevated to 10.7 ng/mL.
Positive_regulation (elevated) of myelin basic protein in leukocytes
8) Confidence 0.50 Published 2000 Journal Pediatr. Neurol. Section Abstract Doc Link 11020647 Disease Relevance 0.91 Pain Relevance 0.21
The protein, immunoglobulin G and myelin basic protein (MBP) were elevated but the tests for oligoclonal band and antiviral antibodies were negative.
Positive_regulation (elevated) of myelin basic protein in band
9) Confidence 0.46 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2612105 Disease Relevance 1.33 Pain Relevance 0.10
The protein, immunoglobulin G and myelin basic protein (MBP) were elevated but the tests for oligoclonal band and antiviral antibodies were negative.
Positive_regulation (elevated) of MBP in band
10) Confidence 0.46 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2612105 Disease Relevance 1.31 Pain Relevance 0.10
Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.
Positive_regulation (positive) of MBP associated with cancer
11) Confidence 0.46 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.29 Pain Relevance 0.25
Of 110 MS patients with chronic progressive disease, 107 had increased CSF anti-MBP and 2 had elevated anti-PLP.
Positive_regulation (increased) of anti-MBP in CSF associated with multiple sclerosis and disease
12) Confidence 0.40 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.20 Pain Relevance 0.66
Considering the total of 370 clinically definite MS patients with active and inactive disease, 77% had increased CSF anti-MBP and 1% had increased CSF anti-PLP.
Positive_regulation (increased) of anti-MBP in CSF associated with multiple sclerosis and disease
13) Confidence 0.40 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 1.13 Pain Relevance 0.62
Serum levels of MBP are elevated in diseases in which there is myelin breakdown.
Positive_regulation (elevated) of MBP associated with disease
14) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1794449 Disease Relevance 1.41 Pain Relevance 0.20
Levels of blood pressure (MBP), HR and muscle sympathetic activity (MSNA) were increased during the acute attack compared to recovery (131 versus 105 mmHg, 100 versus 60 bpm, 88 versus 26 bursts min(-1)).
Positive_regulation (increased) of MBP in sympathetic
15) Confidence 0.36 Published 2004 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 15180190 Disease Relevance 1.12 Pain Relevance 0.08
With respect to autoimmune phenomena, CSF antibody responses to CNS autoantigens such as myelin basic protein (MBP) have been demonstrated [11,25].
Positive_regulation (responses) of MBP associated with central nervous system
16) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 0.87 Pain Relevance 0.18
With respect to autoimmune phenomena, CSF antibody responses to CNS autoantigens such as myelin basic protein (MBP) have been demonstrated [11,25].
Positive_regulation (responses) of myelin basic protein associated with central nervous system
17) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 0.86 Pain Relevance 0.18
at their mature stage [45], play a key role in the thymic selection and in peripheral activation of MBP-restricted CD8+ T cells by the presentation of endogenous MBP on MHC-I [28], [29].
Positive_regulation (activation) of MBP-restricted in T cells
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.42 Pain Relevance 0.11
This leads to the further upregulation of the activity of multiple MMPs and the massive cleavage of MBP in the brain resulting in demyelination and MS [137].
Positive_regulation (upregulation) of MBP in cleavage associated with multiple sclerosis, demyelination and metalloproteinase
19) Confidence 0.25 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.92 Pain Relevance 0.60
CSF examination showed elevation of IgG index (1.6), three oligoclonal bands and myelin basic protein content of 2.4 ng/ml.
Positive_regulation (elevation) of myelin basic protein in bands
20) Confidence 0.24 Published 1993 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8370208 Disease Relevance 0.68 Pain Relevance 0.31

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