INT5410

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.59
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6pd) oxidoreductase activity (G6pd) nucleus (G6pd)
carbohydrate metabolic process (G6pd) cytoplasm (G6pd)
Anatomy Link Frequency
liver 3
respiratory 1
G6pd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 2 100.00 Very High Very High Very High
Paracetamol 16 96.88 Very High Very High Very High
Angina 3 91.76 High High
nud 4 77.32 Quite High
alcohol 5 70.64 Quite High
Glutamate 4 32.00 Quite Low
Pain 1 25.00 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolysis 2 99.96 Very High Very High Very High
Diabetes Mellitus 178 99.64 Very High Very High Very High
Cataract 6 99.28 Very High Very High Very High
Favism 1 99.04 Very High Very High Very High
Anaemia 3 98.02 Very High Very High Very High
Thalassemia 1 94.72 High High
Myocardial Infarction 3 94.24 High High
Cv General 3 Under Development 3 91.76 High High
Coronary Artery Disease 22 86.64 High High
Hypotension 4 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background parenchyma of F344 rats post-treated with butylated hydroxyanisole (BHA), ethoxyquin (EQ) or acetaminophen (AAP).
Gene_expression (expression) of G6PD in liver associated with paracetamol
1) Confidence 0.75 Published 1988 Journal Carcinogenesis Section Abstract Doc Link 2895690 Disease Relevance 0 Pain Relevance 0.18
The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background parenchyma of F344 rats post-treated with butylated hydroxyanisole (BHA), ethoxyquin (EQ) or acetaminophen (AAP).
Gene_expression (expression) of glucose-6-phosphate dehydrogenase in liver associated with paracetamol
2) Confidence 0.75 Published 1988 Journal Carcinogenesis Section Abstract Doc Link 2895690 Disease Relevance 0 Pain Relevance 0.18
Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase in rat liver preneoplastic lesions.
Gene_expression (expression) of glucose-6-phosphate dehydrogenase in liver
3) Confidence 0.75 Published 1988 Journal Carcinogenesis Section Title Doc Link 2895690 Disease Relevance 0 Pain Relevance 0.22
Finally, two diabetic individuals were G-6-PD deficient and did not show cataracts whereas cataracts were identified in six other diabetic patients.
Gene_expression (deficient) of G-6-PD associated with diabetes mellitus and cataract
4) Confidence 0.67 Published 1992 Journal Arch. Med. Res. Section Abstract Doc Link 1308788 Disease Relevance 0.80 Pain Relevance 0.13
Primaquine is contraindicated in patients with severe glucose-6-phosphate dehydrogenase deficiency, therefore, in regions where prevalence of G6PD deficiency is relatively high, G6PD testing is required before administration of primaquine [4].
Gene_expression (deficiency) of glucose-6-phosphate dehydrogenase
5) Confidence 0.66 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 0 Pain Relevance 0
G6PD deficiency and fava bean consumption do not produce hemolysis in Thailand.
Neg (not) Gene_expression (produce) of G6PD associated with analgesic and hemolysis
6) Confidence 0.63 Published 1991 Journal Southeast Asian J. Trop. Med. Public Health Section Title Doc Link 1948276 Disease Relevance 0.49 Pain Relevance 0.16
The primary function of G6PD is to produce NADPH within the cells and its chronic activation will elevate NAD(P)H levels.
Gene_expression (produce) of G6PD
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.31 Pain Relevance 0
Previous studies suggest a reduction in cardiovascular risk among subjects expressing the glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) deficient phenotype.
Gene_expression (expressing) of G6PD
8) Confidence 0.29 Published 2008 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 18392752 Disease Relevance 0.45 Pain Relevance 0.08
The genetic bases of the highly variable degrees of anaemia and haemolysis in persons with Hb SS are not fully known, but several studies have indicated that G6PD deficiency is not a factor.
Gene_expression (deficiency) of G6PD associated with anaemia
9) Confidence 0.23 Published 2010 Journal Br. J. Haematol. Section Abstract Doc Link 20507315 Disease Relevance 0.27 Pain Relevance 0
We aimed to test this hypothesis in male subjects expressing the G6PD-deficient phenotype vs wild type G6PD.
Gene_expression (expressing) of G6PD
10) Confidence 0.23 Published 2008 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 18392752 Disease Relevance 0.49 Pain Relevance 0.09
We aimed to test this hypothesis in male subjects expressing the G6PD-deficient phenotype vs wild type G6PD.
Gene_expression (expressing) of G6PD
11) Confidence 0.20 Published 2008 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 18392752 Disease Relevance 0.51 Pain Relevance 0.09
The activities of different key enzymes (hexokinase, glucose-6-phosphate dehydrogenase and lactate dehydrogenase) are represented in Figs 1, 2 and 3.
Gene_expression (dehydrogenase) of glucose-6-phosphate
12) Confidence 0.19 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.22 Pain Relevance 0
The following chemicals were used for the study: glucose-6-phosphate dehydrogenase, glucose-6-phosphate, lactate dehydrogenase, streptozotocin (Sigma Aldrich Co., Germany); ascorbic acid, meta phosphoric acid, O-phosphoric acid, magnesium chloride, EDTA, sodium citrate (NICE Chemicals Pvt.
Gene_expression (dehydrogenase) of glucose-6-phosphate
13) Confidence 0.19 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.37 Pain Relevance 0.07
The following chemicals were used for the study: glucose-6-phosphate dehydrogenase, glucose-6-phosphate, lactate dehydrogenase, streptozotocin (Sigma Aldrich Co., Germany); ascorbic acid, meta phosphoric acid, O-phosphoric acid, magnesium chloride, EDTA, sodium citrate (NICE Chemicals Pvt.
Gene_expression (dehydrogenase) of glucose-6-phosphate
14) Confidence 0.19 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.36 Pain Relevance 0.07
The significant reversal of diabetes induced decreased levels of glucose-6-phosphate dehydrogenase and lactate dehydrogenase may be attributed to an increase in glucose utilization through the pentose phosphate pathway (32), interfering with the mitochondrial respiratory chain and promoting the peripheral glucose utilization by enhancing anaerobic glycolysis (33).
Gene_expression (dehydrogenase) of glucose-6-phosphate in respiratory associated with diabetes mellitus
15) Confidence 0.19 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.33 Pain Relevance 0

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