INT54102

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.67
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 8
B cell 4
plasma 2
monocyte 2
C cells 2
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 21 100.00 Very High Very High Very High
COX2 2 99.44 Very High Very High Very High
cytokine 61 98.30 Very High Very High Very High
Inflammation 31 98.20 Very High Very High Very High
spinal inflammation 4 96.80 Very High Very High Very High
Angina 8 96.64 Very High Very High Very High
rheumatoid arthritis 7 94.96 High High
chemokine 34 88.80 High High
Catecholamine 22 87.00 High High
cINOD 6 83.80 Quite High
Disease Link Frequency Relevance Heat
Immunization 61 100.00 Very High Very High Very High
Acute Coronary Syndrome 2 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 4 99.46 Very High Very High Very High
INFLAMMATION 38 98.20 Very High Very High Very High
Diabetes Mellitus 68 98.12 Very High Very High Very High
Low Back Pain 4 96.80 Very High Very High Very High
Cv General 3 Under Development 10 96.64 Very High Very High Very High
Atherosclerosis 7 95.20 Very High Very High Very High
Rheumatoid Arthritis 7 94.96 High High
Thrombophilia 2 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We have demonstrated that not only the plasma TF levels but also the plasma-free TFPI levels are elevated in patients with unstable angina.
Positive_regulation (elevated) of Gene_expression (levels) of TFPI in plasma
1) Confidence 0.49 Published 1999 Journal Circulation Section Body Doc Link 10359735 Disease Relevance 0 Pain Relevance 0
Epi-lipoxins (epi-LXs), for instance, are produced from aspirin's acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators.
Positive_regulation (acetylation) of Gene_expression (produced) of epi associated with aspirin and cox2
2) Confidence 0.49 Published 2006 Journal ScientificWorldJournal Section Abstract Doc Link 16951898 Disease Relevance 0.64 Pain Relevance 0.80
Epi-lipoxins (epi-LXs), for instance, are produced from aspirin's acetylation of inducible cyclooxygenase 2 (COX-2) and together with Resolvins represent an increasingly important family of immuno-regulatory and potentially cardio-protective lipid mediators.
Positive_regulation (acetylation) of Gene_expression (produced) of Epi associated with aspirin and cox2
3) Confidence 0.49 Published 2006 Journal ScientificWorldJournal Section Abstract Doc Link 16951898 Disease Relevance 0.64 Pain Relevance 0.80
Hence, the increase in the proportion of deliveries within health facilities will also lead to a better effective coverage of the EPI.
Positive_regulation (coverage) of Gene_expression (coverage) of EPI in EPI associated with immunization
4) Confidence 0.40 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2405792 Disease Relevance 0.43 Pain Relevance 0
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Positive_regulation (Increased) of Gene_expression (levels) of TFPI associated with diabetes mellitus
5) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.21 Pain Relevance 0.04
Elevated plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) and large amounts of monocyte procoagulant activity (PCA) have been documented in unstable angina (UA) patients.
Positive_regulation (Elevated) of Gene_expression (levels) of TFPI in monocyte associated with angina
6) Confidence 0.20 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10235445 Disease Relevance 0.33 Pain Relevance 0.37
Finally, EPI-generated waning of the ?
Positive_regulation (generated) of Gene_expression (generated) of EPI in EPI
7) Confidence 0.19 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0.06 Pain Relevance 0.13
First, a more profound loss of efficacy is observed following 24 hr EPI exposure in BE(2)-C cells as compared to SH?
Positive_regulation (following) of Gene_expression (exposure) of EPI in C cells
8) Confidence 0.19 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
Taking this characteristic of GRK2 and GRK3 into account, the levels of both kinases in membrane fractions following chronic EPI exposure were evaluated.
Positive_regulation (evaluated) of Gene_expression (exposure) of EPI in EPI
9) Confidence 0.19 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.03
Epi produces a significant relaxation in both cases, but the presence of Epi + Asc results in a deeper relaxation than Epi alone.
Positive_regulation (results) of Gene_expression (presence) of Epi
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.04
Quantitative data on the coverage of EPI guided purposeful selection of the areas where qualitative data was collected.
Positive_regulation (coverage) of Gene_expression (coverage) of EPI in EPI associated with immunization
11) Confidence 0.02 Published 2008 Journal Malar J Section Body Doc Link PMC2567329 Disease Relevance 0.17 Pain Relevance 0
The Type 2 cytokines detected are also important mediators of B cell growth and maturation, and thus may allow the production of high levels of persisting anti-CHIKV IgG [5].
Spec (may) Positive_regulation (allow) of Gene_expression (production) of anti-CHIKV IgG in B cell associated with cytokine
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.88 Pain Relevance 0.43
The Type 2 cytokines detected are also important mediators of B cell growth and maturation, and thus may allow the production of high levels of persisting anti-CHIKV IgG [5].
Positive_regulation (levels) of Gene_expression (production) of anti-CHIKV IgG in B cell associated with cytokine
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.88 Pain Relevance 0.43
Increased expression of C-reactive protein and tissue factor in acute coronary syndrome lesions: Correlation with serum C-reactive protein, angioscopic findings, and modification by statins.
Positive_regulation (Increased) of Gene_expression (expression) of tissue factor associated with acute coronary syndrome
14) Confidence 0.00 Published 2009 Journal Atherosclerosis Section Title Doc Link 18508060 Disease Relevance 0.28 Pain Relevance 0.08
In patients with systemic lupus erythaematosus (SLE) the highest frequency of increased serum levels of IgG anti-ClqAb were found, whereas IgA anti-ClqAb were predominantly present in patients with ankylosing spondylitis (AS) and patients with rheumatoid arthritis complicated by vasculitis (RV).
Positive_regulation (increased) of Gene_expression (levels) of anti-ClqAb associated with spinal inflammation, rheumatoid arthritis, increased venous pressure under development and systemic lupus erythematosus
15) Confidence 0.00 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 7899827 Disease Relevance 1.07 Pain Relevance 0.39

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