INT5411

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.74
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6pd) oxidoreductase activity (G6pd) nucleus (G6pd)
carbohydrate metabolic process (G6pd) cytoplasm (G6pd)
Anatomy Link Frequency
peroneal nerve 3
heart 2
myocardium 1
embryos 1
liver 1
G6pd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 38 99.76 Very High Very High Very High
tetrodotoxin 20 99.64 Very High Very High Very High
cINOD 6 98.48 Very High Very High Very High
diclofenac 1 96.88 Very High Very High Very High
anesthesia 7 93.56 High High
Inflammation 4 88.76 High High
headache 1 87.24 High High
abdominal pain 2 86.00 High High
alcohol 1 76.12 Quite High
lidocaine 1 45.20 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 3 99.36 Very High Very High Very High
Hepatotoxicity 4 98.80 Very High Very High Very High
Cataract 6 98.12 Very High Very High Very High
Cv Unclassified Under Development 3 97.80 Very High Very High Very High
Diabetes Mellitus 147 97.36 Very High Very High Very High
Stress 19 97.24 Very High Very High Very High
Blackwater Fever 1 97.04 Very High Very High Very High
Acute Renal Failure 1 95.84 Very High Very High Very High
Heart Rate Under Development 4 95.12 Very High Very High Very High
Arrhythmias 2 Under Development 5 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreases in CAT activity following denervation or injection of BTX or TTX were parallel to increases in G6PD activity observed under these conditions.
Positive_regulation (increases) of G6PD associated with tetrodotoxin
1) Confidence 0.70 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.38
We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle.
Positive_regulation (increases) of glucose-6-phosphate dehydrogenase in skeletal muscle
2) Confidence 0.67 Published 1991 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 1936063 Disease Relevance 0.19 Pain Relevance 0.28
The n-3 PUFA caused increases in the activities of HK, G6PD, LDH, and MDH in comparison with control.
Positive_regulation (increases) of G6PD
3) Confidence 0.66 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15207530 Disease Relevance 0.09 Pain Relevance 0.09
Despite antioxidant deficiencies, and no TBARS change, MDA decreased 26%/33%/37% at 800/1200/1600 mg/kg, which correlated with increased GR (61%/62%/76%, r=0.77) and G6PD (130%/110%/190%, r=0.78).
Positive_regulation (increased) of G6PD
4) Confidence 0.64 Published 2000 Journal Hum Exp Toxicol Section Abstract Doc Link 10918522 Disease Relevance 0.31 Pain Relevance 0.50
Resistance to acetaminophen hepatotoxicity produced by repeated exposure is partially attributable to upregulation of hepatic G6PD and GR activity as an adaptive and protective response to oxidative stress and glutathione depletion.
Spec (partially) Positive_regulation (upregulation) of G6PD associated with stress, paracetamol and hepatotoxicity
5) Confidence 0.64 Published 2000 Journal Hum Exp Toxicol Section Abstract Doc Link 10918522 Disease Relevance 0.39 Pain Relevance 0.36
This conclusion is based upon the observation that subperineural injection of TTX at an identical site in the peroneal nerve caused a small but significant (30%) increase in G6PD activity after 4 days.
Positive_regulation (increase) of G6PD in peroneal nerve associated with tetrodotoxin
6) Confidence 0.61 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.39
Indomethacin increased LP, glutathione peroxidase (GSH-PX) and glucose-6-phosphate dehydrogenase (Glu-6-P-DH) activities and decreased glutathione levels in gastric mucosa.
Positive_regulation (increased) of glucose-6-phosphate dehydrogenase
7) Confidence 0.52 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17199877 Disease Relevance 0.16 Pain Relevance 0.23
Kitahara et.al reported that G6PD activity is significantly elevated in GK rat liver and we have observed similar increases in the myocardium from the Zucker fa/fa rat [51], [54].
Positive_regulation (elevated) of G6PD in myocardium
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.29 Pain Relevance 0
In the Zucker fa/fa rat, chronic activation of glucose-6-phosphate dehydrogenase (G6PD) was brought about via a Src kinase [51].
Positive_regulation (activation) of G6PD
9) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.33 Pain Relevance 0
In the galactosemic rat model G-6-PD deficiency experimentally induced with acetaminophen delayed the development of cataracts.
Positive_regulation (induced) of G-6-PD associated with paracetamol and cataract
10) Confidence 0.50 Published 1992 Journal Arch. Med. Res. Section Abstract Doc Link 1308788 Disease Relevance 0.43 Pain Relevance 0.14
This potentially fatal clinical syndrome can be avoided if patients are tested for G6PD deficiency before the administration of primaquine.
Positive_regulation (tested) of G6PD associated with syndrome
11) Confidence 0.49 Published 2010 Journal Malar J Section Body Doc Link PMC3018394 Disease Relevance 1.23 Pain Relevance 0.17
Selenium produced an increase in the activity of gamma-glutamylcysteine synthetase which may account for the increased glutathione availability in selenium-treated animals and increased the activities of glutathione S-transferase and glucose-6-phosphate dehydrogenase.
Positive_regulation (increased) of glucose-6-phosphate dehydrogenase
12) Confidence 0.49 Published 1988 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2901147 Disease Relevance 0.18 Pain Relevance 0.65
As a result, n-3 PUFA may regulate the metabolic function of liver effectively by increasing HK, G6PD, 6PGD, LDH, and MDH enzyme activities of rat liver when added in enough amounts to the regular diet.
Positive_regulation (increasing) of G6PD in liver
13) Confidence 0.48 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15207530 Disease Relevance 0.08 Pain Relevance 0.08
Denervation of the EDL muscle by section of the peroneal nerve 10-20 mm from its entrance to the muscle caused G6PD activity to increase to 170% of control by day 1 and to 200% and 180% of control by days 2 and 4, respectively.
Positive_regulation (caused) of G6PD in peroneal nerve
14) Confidence 0.47 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.32
Denervation of the EDL muscle by section of the peroneal nerve 10-20 mm from its entrance to the muscle caused G6PD activity to increase to 170% of control by day 1 and to 200% and 180% of control by days 2 and 4, respectively.
Positive_regulation (increase) of G6PD in peroneal nerve
15) Confidence 0.47 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7108545 Disease Relevance 0 Pain Relevance 0.32
In isolated perfused rat hearts, global ischaemia for 20 or 40 min led to a substantial decrease of myocardial ATP, creatine phosphate and glycogen, and to an increase in lactate and glucose-6-phosphate.
Positive_regulation (increase) of glucose-6-phosphate in hearts associated with cv unclassified under development
16) Confidence 0.34 Published 1991 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1772339 Disease Relevance 0.59 Pain Relevance 0
Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase activities as well as vitamins C and E, and glutathione levels were significantly (P<0.05) elevated by the extract.
Positive_regulation (elevated) of glucose-6-phosphate
17) Confidence 0.24 Published 2010 Journal Drug Chem Toxicol Section Abstract Doc Link 19728789 Disease Relevance 0.09 Pain Relevance 0.31
We observe that training significantly increases (50-70%) glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase, and catalase activity in heart and skeletal muscle.
Positive_regulation (increases) of glucose-6-phosphate dehydrogenase in heart
18) Confidence 0.23 Published 1991 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 1936063 Disease Relevance 0.19 Pain Relevance 0.28
Indomethacin treatment led to an increase in lipid peroxidation, glutathione peroxidase and glucose-6-phosphate dehydrogenase activities and to a decrease in catalase activity and glutathione levels in gastric mucosa.
Positive_regulation (increase) of glucose-6-phosphate
19) Confidence 0.21 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391279 Disease Relevance 0.08 Pain Relevance 0.43
We have previously assessed the stability of expression of various housekeeping genes and found the glucose-6-phosphate dehydrogenase (G6PDH) gene to be constant in day-10 and day-11 embryos exposed to high glucose in vitro or diabetes in vivo (data not shown); therefore, we chose the G6PDH gene as a reference in the real-time PCR protocol.
Positive_regulation (constant) of glucose-6-phosphate in embryos associated with diabetes mellitus
20) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.10 Pain Relevance 0

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