INT54116

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.78
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuronal 3
neurons 1
cortex 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
projection neuron 4 100.00 Very High Very High Very High
GABAergic 2 100.00 Very High Very High Very High
Lamotrigine 90 99.70 Very High Very High Very High
dorsal root ganglion 107 99.60 Very High Very High Very High
Cannabinoid receptor 2 98.88 Very High Very High Very High
ischemia 62 98.40 Very High Very High Very High
tetrodotoxin 4 96.44 Very High Very High Very High
agonist 7 94.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 107 99.60 Very High Very High Very High
Cv Unclassified Under Development 63 98.40 Very High Very High Very High
Hypoxia 33 97.88 Very High Very High Very High
Injury 135 89.48 High High
Death 4 79.96 Quite High
Frailty 2 75.00 Quite High
Apoptosis 9 64.84 Quite High
Pressure And Volume Under Development 7 57.60 Quite High
Spinal Injuries 5 55.20 Quite High
Necrosis 6 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
20 mg/kg resulted in a significant increase of NSE staining cells in the cortex and a decrease of NSE level in serum (P < 0.01) (Figure 6).
Negative_regulation (decrease) of NSE in cortex
1) Confidence 0.41 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.48 Pain Relevance 0.43
However, only GABA was decreased relative to the neuronal marker NSE (neuron-specific enolase), indicating a disproportionate loss of GABA production following chronic silencing.
Negative_regulation (decreased) of NSE in neuronal associated with gaba
2) Confidence 0.39 Published 1994 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 7900543 Disease Relevance 0.08 Pain Relevance 0.90
Furthermore, LTG significantly decreased the NSE level in serum and increased the number of NSE staining neurons in the cortex.
Negative_regulation (decreased) of NSE in neurons associated with lamotrigine
3) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721363 Disease Relevance 0.50 Pain Relevance 0.47
The administration of 3NP reduced GABA contents and also mRNA levels for several markers of striatal GABAergic projection neurons, including proenkephalin (PENK), substance P (SP) and neuronal-specific enolase (NSE).
Negative_regulation (reduced) of neuronal-specific enolase in neuronal associated with gaba, gabaergic, projection neuron and substance p
4) Confidence 0.29 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.67
The administration of 3NP reduced GABA contents and also mRNA levels for several markers of striatal GABAergic projection neurons, including proenkephalin (PENK), substance P (SP) and neuronal-specific enolase (NSE).
Negative_regulation (reduced) of NSE in neuronal associated with gaba, gabaergic, projection neuron and substance p
5) Confidence 0.29 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.67
The western blot analysis showing progressive decrease in levels of cellular markers (CNPase, NSE and PGP9.5) up to 4 weeks is likely to reflect the clearance of non-cell associated markers.
Negative_regulation (decrease) of NSE
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2918504 Disease Relevance 0.48 Pain Relevance 0
DRG neurones were fixed 24 hours after co-culturing and receptor expression was determined in NSE-labelled DRG neurones.
Spec (determined) Negative_regulation (determined) of NSE associated with dorsal root ganglion
7) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 1.09 Pain Relevance 0.57

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