INT54137

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.79
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 2
sympathetic 2
sympathetic nervous system 2
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 5 100.00 Very High Very High Very High
Inflammation 43 99.32 Very High Very High Very High
Central nervous system 2 98.60 Very High Very High Very High
Neurotransmitter 2 97.40 Very High Very High Very High
Glutamate 6 95.32 Very High Very High Very High
guanethidine 2 66.64 Quite High
Inflammatory response 7 59.28 Quite High
agonist 3 59.04 Quite High
Clonidine 2 55.48 Quite High
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 5 100.00 Very High Very High Very High
INFLAMMATION 54 99.32 Very High Very High Very High
Increased Venous Pressure Under Development 3 93.16 High High
Microphthalmia 23 36.40 Quite Low
Myocardial Infarction 2 34.52 Quite Low
Coronary Heart Disease 2 33.84 Quite Low
Stress 2 29.60 Quite Low
Overactive Bladder 11 5.00 Very Low Very Low Very Low
Cystitis 8 5.00 Very Low Very Low Very Low
Interstitial Cystitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhancement of PAI-1 mRNA in cardiovascular cells after kainate injection is mediated through the sympathetic nervous system.
Positive_regulation (mediated) of Positive_regulation (Enhancement) of PAI-1 in sympathetic nervous system
1) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 15850565 Disease Relevance 0.09 Pain Relevance 0.24
Here we investigated whether the induction of PAI-1 mRNA by kainate could be mediated through sympathetic versus parasympathetic efferent neurons.
Positive_regulation (mediated) of Positive_regulation (induction) of PAI-1 in sympathetic
2) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.09 Pain Relevance 0.26
In addition, inflammation associated with PAR2 stimulation led to an up-regulation of serpine 1, WT1, cyclin D1, IGF1R, and cathepsin K.


Positive_regulation (led) of Positive_regulation (up-regulation) of serpine 1 associated with inflammation
3) Confidence 0.19 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.24 Pain Relevance 0.12
On the other hand, the plasma levels of PAI activity (IU/ml) and t-PA antigen (ng/ml) in patients with unstable angina were significantly higher on admission than after treatment (PAI activity: 11.4 +/- 1.4 vs 7.7 +/- 1.5, t-PA antigen: 8.7 +/- 0.9 vs 7.0 +/- 0.9, p < 0.01).
Positive_regulation (higher) of Positive_regulation (levels) of PAI in plasma associated with angina
4) Confidence 0.14 Published 1993 Journal Jpn. Circ. J. Section Abstract Doc Link 7901435 Disease Relevance 0.36 Pain Relevance 0.43

General Comments

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