INT5415

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.94
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia4) endoplasmic reticulum (Pdia4)
Anatomy Link Frequency
cardiomyocytes 1
Pdia4 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 100.00 Very High Very High Very High
Pain 1 99.98 Very High Very High Very High
agonist 6 99.26 Very High Very High Very High
Opioid 3 99.14 Very High Very High Very High
opioid receptor 2 99.10 Very High Very High Very High
antagonist 3 98.24 Very High Very High Very High
Enkephalin 9 93.60 High High
narcan 4 93.20 High High
lidocaine 2 90.08 High High
MU agonist 1 80.96 Quite High
Disease Link Frequency Relevance Heat
Pain 1 99.98 Very High Very High Very High
Neuroblastoma 1 90.64 High High
Cancer 4 81.84 Quite High
Pancreatic Cancer 5 77.52 Quite High
Metastasis 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observed pain reduction in nearly all patients under CAI.
Negative_regulation (reduction) of CAI associated with pain
1) Confidence 0.36 Published 1999 Journal World J Surg Section Abstract Doc Link 10449825 Disease Relevance 0.85 Pain Relevance 0.17
The Cai plateau was reduced to resting levels by either the muscarinic antagonist atropine (1 microM) or the inorganic Ca2+ channel blocker lanthanum (effective concentration for 50% inhibition of Cai plateau EC50 = 68 +/- 18 nM), but it was unaffected by the organic Ca2+ channel blockers verapamil and nifedipine.
Negative_regulation (inhibition) of Cai associated with antagonist
2) Confidence 0.06 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.21
The Cai plateau was reduced to resting levels by either the muscarinic antagonist atropine (1 microM) or the inorganic Ca2+ channel blocker lanthanum (effective concentration for 50% inhibition of Cai plateau EC50 = 68 +/- 18 nM), but it was unaffected by the organic Ca2+ channel blockers verapamil and nifedipine.
Negative_regulation (reduced) of Cai associated with antagonist
3) Confidence 0.04 Published 1992 Journal Pflugers Arch. Section Abstract Doc Link 1437524 Disease Relevance 0 Pain Relevance 0.20
In rat ventricular cardiomyocytes loaded with the fluorescent Ca2+ indicator Indo-1/AM, the delta opioid receptor agonist Leu-Enk caused Cai oscillations and abolished the caffeine-induced Cai transient.
Negative_regulation (abolished) of Cai in cardiomyocytes associated with agonist and opioid receptor
4) Confidence 0.04 Published 1991 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 1657046 Disease Relevance 0 Pain Relevance 0.48
Thus, delta and kappa but not mu opioids have a negative inotropic action due to a decreased Cai transient.
Negative_regulation (decreased) of Cai associated with opioid
5) Confidence 0.03 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1309318 Disease Relevance 0.09 Pain Relevance 0.54
In four cells, the Cai transient remaining in the presence of nifedipine plus TTX was abolished by adding 5 mM Ni.
Negative_regulation (abolished) of Cai associated with tetrodotoxin
6) Confidence 0.02 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8594540 Disease Relevance 0 Pain Relevance 0.33

General Comments

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