INT54170

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
projection neurons 4
striatum 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
nMDA receptor 6 99.66 Very High Very High Very High
projection neuron 4 99.48 Very High Very High Very High
Ventral tegmentum 2 97.56 Very High Very High Very High
antagonist 1 97.20 Very High Very High Very High
Substantia nigra 2 96.48 Very High Very High Very High
GABAergic 4 94.20 High High
Enkephalin 5 85.44 High High
tetrodotoxin 1 82.80 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, NMDA receptors are unlikely to contribute to the dopamine lesion-induced GAD67 mRNA up-regulation in striatal projection neurons.
Positive_regulation (induced) of Positive_regulation (up-regulation) of GAD67 in projection neurons associated with dopamine, nmda receptor and projection neuron
1) Confidence 0.69 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.60
The increased GABA release and the apparent adaptive increase in GAD67 mRNA levels by the strongest stimulation may be due to an endogenous inhibitory neuroprotective response to an excitotoxic influence.
Positive_regulation (increased) of Positive_regulation (increase) of GAD67 associated with gaba
2) Confidence 0.50 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332739 Disease Relevance 0 Pain Relevance 0.48
Regional analysis of labeling showed that the increased GAD67, preproenkephalin or dopamine D2 receptor mRNA levels occurred in all striatal sectors examined.
Positive_regulation (occurred) of Spec (examined) Positive_regulation (increased) of GAD67 associated with dopamine
3) Confidence 0.50 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.45
In the striatum of adults, both doses of 6-hydroxydopamine induced an increase in GAD67 and preproenkephalin mRNA levels compared to controls.
Positive_regulation (induced) of Positive_regulation (increase) of GAD67 in striatum
4) Confidence 0.50 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.39
The increases in GAD67, GAD65, and PPD mRNA levels induced by SKF-38393 were abolished by the administration of the D1 receptor antagonist SCH-23390.
Positive_regulation (increases) of Positive_regulation (induced) of GAD67 associated with antagonist
5) Confidence 0.48 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
Therefore, NMDA receptors are unlikely to contribute to the dopamine lesion-induced GAD67 mRNA up-regulation in striatal projection neurons.
Positive_regulation (contribute) of Positive_regulation (up-regulation) of GAD67 in projection neurons associated with dopamine, nmda receptor and projection neuron
6) Confidence 0.46 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.61

General Comments

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