INT5418

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 108
Total Number 109
Disease Relevance 42.09
Pain Relevance 31.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
platelet 4
leukocyte 2
paw 2
RBL-1 2
erythrocyte 1
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 614 100.00 Very High Very High Very High
Pain 27 100.00 Very High Very High Very High
cINOD 68 99.98 Very High Very High Very High
Paracetamol 10 99.98 Very High Very High Very High
aspirin 35 99.94 Very High Very High Very High
licofelone 2 99.84 Very High Very High Very High
qutenza 20 99.70 Very High Very High Very High
dexamethasone 7 99.40 Very High Very High Very High
Inflammatory response 71 99.36 Very High Very High Very High
antagonist 27 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Mastocytoma 2 100.00 Very High Very High Very High
INFLAMMATION 793 99.84 Very High Very High Very High
Injury 426 99.72 Very High Very High Very High
Diabetes Mellitus 6 99.64 Very High Very High Very High
Brain Hemorrhage 152 99.60 Very High Very High Very High
Hyperalgesia 62 98.90 Very High Very High Very High
Rheumatoid Arthritis 14 98.88 Very High Very High Very High
Ulcers 6 98.88 Very High Very High Very High
Arthus Reaction 4 98.76 Very High Very High Very High
Corneal Neovascularization 2 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MRQ could also increase the reaction time of rats in the hot-plate test (by 57% after the first hour of treatment), although it had no effect on the reaction time in the tail-flick test, indicating that MRQ possesses analgesic activity that is probably mediated via a supra-spinal effect.MRQ also exerted a dose-dependent (a) protective effect on heat-induced erythrocyte lysis, and (b) inhibition of 5-lipoxygenase activity.
Negative_regulation (inhibition) of 5-lipoxygenase in erythrocyte associated with analgesic and tail-flick
1) Confidence 0.57 Published 2003 Journal J Ethnopharmacol Section Abstract Doc Link 12639750 Disease Relevance 0.89 Pain Relevance 0.75
In addition, at these same high concentrations, acetaminophen inhibited 5-lipoxygenase activity in cultured RBL-1 cells.
Negative_regulation (inhibited) of 5-lipoxygenase in RBL-1 associated with paracetamol
2) Confidence 0.57 Published 1983 Journal Prostaglandins Leukot Med Section Abstract Doc Link 6422475 Disease Relevance 0 Pain Relevance 0.75
These effects were attenuated by co-administration of morphine with selective and nonselective lipoxygenase inhibitors.
Negative_regulation (inhibitors) of lipoxygenase associated with morphine
3) Confidence 0.48 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15102529 Disease Relevance 0.29 Pain Relevance 1.39
The mechanism by which this evolves, however, appears to be unrelated to direct inhibition of lipoxygenase.
Negative_regulation (inhibition) of lipoxygenase
4) Confidence 0.46 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3085488 Disease Relevance 0.22 Pain Relevance 0.35
Cellular 5-LOX activation was obtained by adding calcium ionophore (A23187) into the pouch thus providing a novel model to evaluate the efficacy and selectivity of 5-LOX inhibitors.
Negative_regulation (inhibitors) of 5-LOX
5) Confidence 0.43 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18295198 Disease Relevance 0.65 Pain Relevance 0.22
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Negative_regulation (inhibitor) of 5-lipoxygenase
6) Confidence 0.42 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 2835137 Disease Relevance 0.24 Pain Relevance 0.14
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Negative_regulation (inhibitors) of 5-lipoxygenase associated with inflammation
7) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18295198 Disease Relevance 0.84 Pain Relevance 0.37
The subcutaneous sponge implant model of acute inflammation in the rat has been evaluated as a suitable test system for evaluating the potential anti-inflammatory efficacy of 5-lipoxygenase inhibitors.
Negative_regulation (inhibitors) of 5-lipoxygenase associated with inflammation
8) Confidence 0.42 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.45 Pain Relevance 0.30
Whereas treatment with a 5-lipoxygenase inhibitor, PF-5901 (100 mg/kg PO), resulted in a significant reduction of the severity of colitis, concomitant administration of PF-5901 and indomethacin (0.5 mg/kg SC) did not inhibit the exacerbative effects of the indomethacin in this model.
Negative_regulation (inhibitor) of 5-lipoxygenase associated with colitis
9) Confidence 0.42 Published 1992 Journal Gastroenterology Section Abstract Doc Link 1309357 Disease Relevance 0.65 Pain Relevance 0.15
This model therefore is of little value for evaluating the anti-inflammatory efficacy of 5-lipoxygenase inhibitors.
Negative_regulation (inhibitors) of 5-lipoxygenase associated with inflammation
10) Confidence 0.42 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3011012 Disease Relevance 0.33 Pain Relevance 0.25
Two selective inhibitors of 5-lipoxygenase, i.e.
Negative_regulation (inhibitors) of 5-lipoxygenase
11) Confidence 0.42 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8774948 Disease Relevance 0 Pain Relevance 0.08
We recently showed that benzo[g]indol-3-carboxylates potently suppress leukotriene biosynthesis by inhibiting 5-lipoxygenase.
Negative_regulation (inhibiting) of 5-lipoxygenase
12) Confidence 0.42 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19884011 Disease Relevance 0.42 Pain Relevance 0.26
Together, based on the select and potent inhibition of mPGES-1 and 5-lipoxygenase, benzo[g]indol-3-carboxylates possess potential as novel anti-inflammatory drugs with a valuable pharmacological profile.
Negative_regulation (inhibition) of 5-lipoxygenase associated with inflammation and cinod
13) Confidence 0.42 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19884011 Disease Relevance 0.61 Pain Relevance 0.31
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol) was a potent inhibitor of leukotriene biosynthesis in intact rat and human leukocytes and CXBG mastocytoma cells (IC50 values, 18-240 nM) and of crude human leukocyte and highly purified porcine leukocyte 5-lipoxygenase (IC50 value, 4 X 10(-7) M).
Negative_regulation (inhibitor) of 5-lipoxygenase in leukocyte associated with mastocytoma
14) Confidence 0.41 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2835137 Disease Relevance 0.25 Pain Relevance 0.13
The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor.
Negative_regulation (inhibitor) of 5-lipoxygenase associated with inflammation and cox1
15) Confidence 0.41 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19243697 Disease Relevance 0.41 Pain Relevance 0.37
Our results would suggest that, independently of its 5-lipoxygenase blocking activity, nafazatrom inhibits the contractions of the rat uterus by inhibiting the calmodulin activity and, presumably, by reducing the influx of extracellular calcium and/or the mobilization of intracellular calcium.
Negative_regulation (inhibits) of 5-lipoxygenase in uterus
16) Confidence 0.41 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2560365 Disease Relevance 0.08 Pain Relevance 0.08
Evaluation of 5-LOX metabolites-by LC/MS/MS and ELISA confirmed that both compounds selectively inhibited all products downstream of 5-hydroperoxy eicosatetraenoic acid (5-HPETE), including 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxoETE), without inhibition of 12-lipoxygenase (12-LOX), 15-lipoxygenase (15-LOX), or cyclooxygenase (COX) products.
Negative_regulation (inhibition) of 5-lipoxygenase
17) Confidence 0.41 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18295198 Disease Relevance 0.05 Pain Relevance 0.07
Inhibition of lipoxygenase of rat dental pulp and human platelets by phenolic dental medicaments.
Negative_regulation (Inhibition) of lipoxygenase in platelets
18) Confidence 0.41 Published 1990 Journal Dent Jpn (Tokyo) Section Title Doc Link 2129162 Disease Relevance 0 Pain Relevance 0.09
However, it is unclear whether the inhibition of the LO activity regulates the expression of c-Fos protein, a pain marker in the spinal cord.
Spec (whether) Negative_regulation (inhibition) of LO in spinal cord associated with pain and spinal cord
19) Confidence 0.41 Published 2009 Journal Mol. Cells Section Abstract Doc Link 19390822 Disease Relevance 0.26 Pain Relevance 0.30
Nordihydroguaiaretic acid (NDGA) is a lipoxygenase (LO) inhibitor with a strong antioxidant activity.
Negative_regulation (inhibitor) of lipoxygenase
20) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16423329 Disease Relevance 0.32 Pain Relevance 0.22

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