INT54257

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.71
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
kidney 1
H2-M3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 55 99.54 Very High Very High Very High
Eae 2 98.60 Very High Very High Very High
depression 3 98.24 Very High Very High Very High
Pain 1 98.00 Very High Very High Very High
visual analogue scale 1 95.76 Very High Very High Very High
Central nervous system 2 95.56 Very High Very High Very High
analgesia 3 81.60 Quite High
epidural 3 78.88 Quite High
addiction 2 71.60 Quite High
Disease Link Frequency Relevance Heat
Aging 2 98.68 Very High Very High Very High
Respiratory Failure 3 98.24 Very High Very High Very High
Pain 1 98.00 Very High Very High Very High
Cancer 2 75.00 Quite High
Drug Dependence 1 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, pretreatment with M3G induced sensitization of morphine locomotor activity but not M6G.
M3G Binding (pretreatment) of associated with eae and morphine
1) Confidence 0.03 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18555521 Disease Relevance 0.07 Pain Relevance 1.56
There was significant (p < 0.05) extraction (mean +/- SD) of morphine by the liver (0.676 +/- 0.014) and kidney (0.602 +/- 0.039), net extraction of M3G (0.106 +/- 0.046) and M6G (0.104 +/- 0.030) by the kidney, and net formation of M3G (-0.057 +/- 0.017) by the gut.
M3G Binding (formation) of in kidney associated with morphine
2) Confidence 0.02 Published 1993 Journal Drug Metab. Dispos. Section Abstract Doc Link 7905398 Disease Relevance 0 Pain Relevance 0.96
The mean (+/-s.d.) ratio for the rate of formation of M3G relative to M6G was 3.7 +/- 1.5.
M3G Binding (formation) of
3) Confidence 0.01 Published 1997 Journal Pharm. Res. Section Body Doc Link 9279882 Disease Relevance 0 Pain Relevance 0
Indication of cerebral formation of M3G was found in 1 patient.
M3G Binding (formation) of
4) Confidence 0.00 Published 1993 Journal Pain Section Abstract Doc Link 8455965 Disease Relevance 0.24 Pain Relevance 1.52
Morphine-3-beta-D-glucuronide (M3G) also crossed the blood-brain barrier, but is less permeable than M6G (mean brain-to-plasma ratio = 0.022).
M3G Binding (crossed) of in plasma associated with morphine
5) Confidence 0.00 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965704 Disease Relevance 0.40 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox