INT5426

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 58
Total Number 61
Disease Relevance 12.34
Pain Relevance 25.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RTCA) RNA binding (RTCA) nucleus (RTCA)
ligase activity (RTCA)
Anatomy Link Frequency
SH-SY5Y 3
platelet 3
fat cells 3
NG108-15 1
T84 1
RTCA (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 40 100.00 Very High Very High Very High
narcan 36 100.00 Very High Very High Very High
agonist 173 99.98 Very High Very High Very High
Enkephalin 38 99.94 Very High Very High Very High
tolerance 13 99.92 Very High Very High Very High
opioid receptor 38 99.80 Very High Very High Very High
Morphine 63 99.68 Very High Very High Very High
Potency 37 99.68 Very High Very High Very High
nMDA receptor antagonist 1 99.34 Very High Very High Very High
Opioid 51 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 31 99.48 Very High Very High Very High
Obesity 124 98.88 Very High Very High Very High
Glioma 14 98.84 Very High Very High Very High
Bordatella Infection 32 98.66 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.36 Very High Very High Very High
Cystic Fibrosis 1 98.24 Very High Very High Very High
Hyponatremia 62 97.80 Very High Very High Very High
Urological Neuroanatomy 1 97.44 Very High Very High Very High
Anxiety Disorder 112 96.76 Very High Very High Very High
Hypertension 3 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The characteristics of specific binding of endogenous opiate with the cells, as well s a decrease in the activity of lymphocyte adenylate cyclase observed under the effect of met-enkephalin proved the presence of a specific interplay between the physiological concentrations of the opiate with lymphocytes.
Negative_regulation (decrease) of cyclase in lymphocytes associated with enkephalin and opiate
1) Confidence 0.51 Published 1982 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 7102200 Disease Relevance 0 Pain Relevance 0.54
The alterations in alpha 2-adrenoceptor densities were paralleled by a decreased adrenaline-induced inhibition of adenylate cyclase activity (P less than 0.01).
Negative_regulation (inhibition) of cyclase
2) Confidence 0.51 Published 1987 Journal J Hypertens Suppl Section Abstract Doc Link 2832574 Disease Relevance 0.23 Pain Relevance 0.69
Among them, the aryl sulfonamide derivative 5q (pD2 = 8.33 compare to 5.75 for sumatriptan) was also identified as a very potent agonist in inhibiting the forskolin-mediated cyclase coupled to 5-HT1D beta receptors (EC50 = 0.52nM).
Negative_regulation (inhibiting) of cyclase associated with sumatriptan and agonist
3) Confidence 0.51 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658447 Disease Relevance 0 Pain Relevance 0.35
Meanwhile adenylate cyclase was inhibited and guanylate cyclase was stimulated.
Negative_regulation (inhibited) of cyclase
4) Confidence 0.40 Published 1987 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2826349 Disease Relevance 0 Pain Relevance 0.31
The alpha 2-adrenergic receptor on the human platelet is known to mediate the inhibition of adenylate cyclase activity.
Negative_regulation (inhibition) of cyclase in platelet
5) Confidence 0.34 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 2981397 Disease Relevance 0 Pain Relevance 0.17
Impaired coupling of naloxone sensitive opiate receptors to adenylate cyclase in PMNLs of aged male subjects.
Negative_regulation (Impaired) of cyclase associated with narcan and opiate
6) Confidence 0.29 Published 1987 Journal Int. J. Immunopharmacol. Section Title Doc Link 2826349 Disease Relevance 0 Pain Relevance 0.47
Alkylation of receptors by beta-chlornaltrexamine, although it reduced [3H]naltrexone binding by 50%, did not significantly alter the rank order of opioid agonists based on their ability to acutely inhibit adenylate cyclase.
Negative_regulation (inhibit) of cyclase associated with mu agonist
7) Confidence 0.19 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8383804 Disease Relevance 0.09 Pain Relevance 0.81
In differentiated SH-SY5Y human neuroblastoma cells, various opioids exhibited a wide range of potencies (Ki) in acutely inhibiting adenylate cyclase to different extents (Imax).
Negative_regulation (inhibiting) of cyclase in SH-SY5Y associated with neuroblastoma and opioid
8) Confidence 0.19 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8383804 Disease Relevance 0.10 Pain Relevance 0.54
On the other hand, these parameters were only marginally affected by agonists of lower acute potency, such as profadol and morphiceptin, regardless of their Imax in inhibiting adenylate cyclase.
Negative_regulation (inhibiting) of cyclase associated with agonist and potency
9) Confidence 0.19 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8383804 Disease Relevance 0.14 Pain Relevance 0.79
Long term treatment of the cells with agonists of high acute potency, such as Tyr-D-Ala-Gly-(Me)Phe-Gly-ol and levorphanol, decreased the Bmax of the antagonist [3H]naltrexone by 80-95%, increased the Ks for GTPase stimulation 10-14-fold, and increased the Ki for adenylate cyclase inhibition 2-3-fold.
Negative_regulation (inhibition) of cyclase associated with antagonist, agonist and potency
10) Confidence 0.19 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8383804 Disease Relevance 0.13 Pain Relevance 0.70
Competition studies reveal a selectivity profile similar to that of sigma1 sites in guinea pig brain. (+)-Pentazocine has no effect upon either basal or forskolin-stimulated cyclase in the BE(2)-C cells, but cAMP accumulation is inhibited by the morphine, DPDPE and naloxone benzoylhydrazone. (+)-Pentazocine at concentrations as high as 10 microM does not affect this opioid effect, implying that sigma1/opioid interactions are not mediated at the level of the cell.
Negative_regulation (inhibited) of cyclase in C cells associated with fortral, narcan, opioid and morphine
11) Confidence 0.17 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947921 Disease Relevance 0.16 Pain Relevance 0.95
Evaluation of the functional interaction between PGE1 receptors and GS in situ by application of a C-terminal anti-GSalpha antibody revealed a more intense coupling efficiency between these two entities, since a significant higher amount of antibody (2.3-fold) was required in morphine dependent cell membranes to half-maximally attenuate PGE1 receptor-stimulated adenylate cyclase activity.
Negative_regulation (attenuate) of cyclase associated with morphine
12) Confidence 0.16 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.31 Pain Relevance 0.56
While etorphine, a non-selective alkaloid agonist, caused 50% desensitization after a 30-min incubation, the same treatment in the presence of the selective peptide agonists, DPDPE ([D-Pen2,D-Pen5]enkephalin) and deltorphin I (Tyr-D-Ala-Phe-Asp-Val-Val-Gly), almost totally desensitized the delta-opioid receptor-mediated inhibition of adenylyl cyclase.
Negative_regulation (inhibition) of cyclase associated with agonist, opioid receptor, enkephalin and immobilon
13) Confidence 0.14 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10357261 Disease Relevance 0.08 Pain Relevance 0.69
We concluded that morphine may exert its potentiation in platelet aggregation by binding to alpha(2)-adrenoceptors in human platelets, with a resulting inhibition of adenylate cyclase, thereby reducing intracellular cyclic AMP formation followed by increased activation of phospholipase C and the Na(+)/H(+) exchanger.
Negative_regulation (inhibition) of cyclase in platelets associated with morphine
14) Confidence 0.13 Published 2003 Journal J. Biomed. Sci. Section Abstract Doc Link 12711856 Disease Relevance 0 Pain Relevance 0.79
These results provide further evidence that mu-receptors are coupled to inhibition of adenylate cyclase and that the SH-SY5Y cell line is a good system for assessment of mu-agonists functional responses.
Negative_regulation (inhibition) of cyclase in SH-SY5Y associated with agonist
15) Confidence 0.11 Published 1992 Journal Life Sci. Section Abstract Doc Link 1309468 Disease Relevance 0.06 Pain Relevance 0.28
After 24 hr of chronic administration of PLO17 (50 nM to 10 microM), a concentration-dependent loss of the ability of mu opioid agonists PLO17 and DAMGO, but not the delta opioid agonists DPDPE, nor alpha-2 adrenergic agonist UK-14304 (5-Bromo-N-(4,5,-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine) to inhibit adenylate cyclase activity was observed.
Negative_regulation (inhibit) of cyclase associated with mu agonist and agonist
16) Confidence 0.09 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8035314 Disease Relevance 0.22 Pain Relevance 1.05
We recently described the cloning of a fifth member of the 5-hydroxytryptamine (5-HT)1 (serotonin1) receptor class that inhibits adenylyl cyclase, namely the human 5-HT1F receptor (Adham et al. 1993a).
Negative_regulation (inhibits) of cyclase
17) Confidence 0.08 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8133900 Disease Relevance 0 Pain Relevance 0
The expressed mu-receptors also mediated agonist inhibition of adenylate cyclase, indicating that these receptors are functionally coupled to intracellular signalling pathways.
Negative_regulation (inhibition) of cyclase associated with agonist
18) Confidence 0.07 Published 1996 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 8767728 Disease Relevance 0.31 Pain Relevance 0.48
In conclusion, insulin and adenylate cyclase inhibitors are antilipolytic in human fat cells through different mechanisms.
Negative_regulation (inhibitors) of cyclase in fat cells associated with obesity
19) Confidence 0.07 Published 1989 Journal Int J Obes Section Abstract Doc Link 2545639 Disease Relevance 0.56 Pain Relevance 0.25
Adenylate cyclase inhibitors act predominantly on the GTP-sensitive coupling proteins and, to a minor extent, at some yet unidentified distal step in the lipolytic machinery.
Negative_regulation (inhibitors) of cyclase
20) Confidence 0.07 Published 1989 Journal Int J Obes Section Abstract Doc Link 2545639 Disease Relevance 0.54 Pain Relevance 0.24

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