INT54284

Context Info Confidence 0.42 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 4.56 Pain Relevance 14.34

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency NAc 2 cardiac myocytes 2 chromaffin cells 2 DRt 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 341 100.00 Morphine 231 100.00 Opioid 195 100.00 agonist 117 100.00 Pain 67 100.00 Anterior cingulate cortex 50 100.00 antagonist 43 100.00 Kappa opioid receptor 11 100.00 narcan 10 100.00 mu opioid receptor 7 100.00

Disease Link Frequency Relevance Heat Pain 91 100.00 Inflammatory Pain 20 99.86 INFLAMMATION 68 99.68 Arrhythmias 2 Under Development 12 99.42 Ganglion Cysts 28 97.20 Nociception 43 94.56 Cough 93 94.24 Post Operative Pain 2 93.16 Bordatella Infection 2 92.60 Sleep Disorders 1 89.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is therefore a broad, but tissue specific distribution of opioid receptor expression in the periphery of the rat, suggesting that the endogenous opioid peptides play an endocrine, paracrine, or autocrine role in the regulation of physiology at a peripheral as well as central level.

Negative_regulation (distribution) of Gene_expression (expression) of opioid receptor associated with endogenous opioid and opioid receptor

1) Confidence 0.42 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.50

The delta-opioid receptor agonists SNC80 ((+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide) and (+)BW373U86 ((+)-[1(S*),2 alpha,5 beta]-4-[[2,5-dimethyl-4-(2-propenyl)-1-piperazinyl] (3-hydroxyphenyl)methyl]-N,N-diethyl-benzamide dihydrochloride) produced a decrease in immobility indicating an antidepressant-like effect.

Negative_regulation (decrease) of Gene_expression (produced) of opioid receptor associated with antidepressant, agonist and opioid receptor

2) Confidence 0.36 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12007745 Disease Relevance 0 Pain Relevance 0.85

The levels of this biologically active K opioid receptor agonist significantly increased after 4 h of KCl treatment and were markedly reduced following a 24-h exposure of the cardiac myocytes to KCl.

Negative_regulation (reduced) of Gene_expression (levels) of K opioid receptor in cardiac myocytes associated with agonist and opioid receptor

3) Confidence 0.34 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7906274 Disease Relevance 0 Pain Relevance 0.47

The kappa opioid receptor agonists (+)-U69,593 (0.1-0.56mg/kg), (+/-)-U50,488 (1.0-5.6mg/kg) and racemic GR89,696 (0.0003-0.01mg/kg) all produced dose-related decreases in the percentage of trials terminated by a correct or incorrect response and increases in the percentage of omissions.

Negative_regulation (decreases) of Gene_expression (produced) of opioid receptor associated with agonist and kappa opioid receptor

4) Confidence 0.33 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17959202 Disease Relevance 0.09 Pain Relevance 0.51

-opioid receptor densities in the NAc and posteromedial cortical amygdala, and a decrease in the basolateral amygdala.

Negative_regulation (decrease) of Gene_expression (densities) of opioid receptor in NAc associated with nucleus accumbens, opioid receptor and amygdala

5) Confidence 0.19 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890660 Disease Relevance 0 Pain Relevance 1.93

The DRt exhibits plastic changes during chronic inflammatory pain, with decrease opioid receptor expression which may account for increased descending facilitation during chronic pain.

Negative_regulation (decrease) of Gene_expression (expression) of opioid receptor in DRt associated with lasting pain, ipn, ascending facilitation and opioid receptor

6) Confidence 0.12 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18725300 Disease Relevance 0.69 Pain Relevance 1.34

The understanding of this gene's regulation should have widespread importance, not only to those interested in opioid gene expression, but also to those interested in gene regulation, in general.

Negative_regulation (interested) of Gene_expression (expression) of opioid gene associated with opioid

7) Confidence 0.09 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9610395 Disease Relevance 0 Pain Relevance 0.13

Persistent AF is associated with the down-regulation of the opioid receptor/ligand expression.

Negative_regulation (regulation) of Gene_expression (expression) of opioid receptor associated with arrhythmias 2 under development and opioid receptor

8) Confidence 0.07 Published 2005 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 15683515 Disease Relevance 1.01 Pain Relevance 0.23

Pain-induced opioid receptor trafficking and pain inhibition

Negative_regulation (inhibition) of Gene_expression (trafficking) of opioid receptor associated with pain and opioid receptor

9) Confidence 0.04 Published 2007 Journal Mol Pain Section Body Doc Link PMC2219988 Disease Relevance 0.96 Pain Relevance 1.49

Mechanisms of opioid receptor trafficking

Negative_regulation (Mechanisms) of Gene_expression (trafficking) of opioid receptor associated with opioid receptor

10) Confidence 0.04 Published 2007 Journal Mol Pain Section Body Doc Link PMC2219988 Disease Relevance 0.35 Pain Relevance 1.02

-opioid receptor agonists also inhibited excitatory postsynaptic potentials in the NTS but they are less effective than ?

Negative_regulation (inhibited) of Gene_expression (agonists) of opioid receptor associated with agonist and opioid receptor

11) Confidence 0.03 Published 2007 Journal Cough Section Body Doc Link PMC1950526 Disease Relevance 0.30 Pain Relevance 1.04

Local injection of the opioid receptor antagonist naloxone, anti-Met-enkephalin or anti-?

Negative_regulation (naloxone) of Gene_expression (injection) of opioid receptor associated with antagonist, narcan, enkephalin and opioid receptor

12) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.91 Pain Relevance 1.25

RT-PCR revealed the expression of mu-, delta- and kappa-opioid receptor mRNAs in cultured adrenal chromaffin cells.

Negative_regulation (revealed) of Gene_expression (expression) of opioid receptor in chromaffin cells associated with kappa opioid receptor

13) Confidence 0.02 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031848 Disease Relevance 0.09 Pain Relevance 0.72

These results suggested that (1) Long-term administration of either peptide or non-peptide opioid agonist to cultured cell line produced a significant decrease of the gene expression of opioid receptor at transcription level. (2) The effect of peptide agonists was stronger and lasted longer than that of corresponding nonpeptide agonists.

Negative_regulation (decrease) of Gene_expression (expression) of opioid receptor associated with mu agonist, agonist and opioid receptor

14) Confidence 0.01 Published 2001 Journal Life Sci. Section Abstract Doc Link 11400915 Disease Relevance 0 Pain Relevance 0.58

The mu opioid receptor is robustly expressed in the ACC [54] and microinjection of morphine directly into the ACC reduced the affective component of pain [55].

Negative_regulation (reduced) of Gene_expression (expressed) of opioid receptor associated with pain, mu opioid receptor, anterior cingulate cortex and morphine

15) Confidence 0.01 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.16 Pain Relevance 1.62

Opioid receptor antagonism and inhibition of opioid gene expression by a prodynorphin antisense phosphorothioate oligonucleotide blocked DMSO-induced cardiogenesis, suggesting an autocrine role of an opioid gene in developmental decisions.

Negative_regulation (inhibition) of Gene_expression (expression) of opioid gene associated with opioid receptor and opioid

16) Confidence 0.00 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.66

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