INT54284
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
There is therefore a broad, but tissue specific distribution of opioid receptor expression in the periphery of the rat, suggesting that the endogenous opioid peptides play an endocrine, paracrine, or autocrine role in the regulation of physiology at a peripheral as well as central level. | |||||||||||||||
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The delta-opioid receptor agonists SNC80 ((+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide) and (+)BW373U86 ((+)-[1(S*),2 alpha,5 beta]-4-[[2,5-dimethyl-4-(2-propenyl)-1-piperazinyl] (3-hydroxyphenyl)methyl]-N,N-diethyl-benzamide dihydrochloride) produced a decrease in immobility indicating an antidepressant-like effect. | |||||||||||||||
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The levels of this biologically active K opioid receptor agonist significantly increased after 4 h of KCl treatment and were markedly reduced following a 24-h exposure of the cardiac myocytes to KCl. | |||||||||||||||
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The kappa opioid receptor agonists (+)-U69,593 (0.1-0.56mg/kg), (+/-)-U50,488 (1.0-5.6mg/kg) and racemic GR89,696 (0.0003-0.01mg/kg) all produced dose-related decreases in the percentage of trials terminated by a correct or incorrect response and increases in the percentage of omissions. | |||||||||||||||
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-opioid receptor densities in the NAc and posteromedial cortical amygdala, and a decrease in the basolateral amygdala. | |||||||||||||||
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The DRt exhibits plastic changes during chronic inflammatory pain, with decrease opioid receptor expression which may account for increased descending facilitation during chronic pain. | |||||||||||||||
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The understanding of this gene's regulation should have widespread importance, not only to those interested in opioid gene expression, but also to those interested in gene regulation, in general. | |||||||||||||||
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Persistent AF is associated with the down-regulation of the opioid receptor/ligand expression. | |||||||||||||||
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Pain-induced opioid receptor trafficking and pain inhibition | |||||||||||||||
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Mechanisms of opioid receptor trafficking | |||||||||||||||
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-opioid receptor agonists also inhibited excitatory postsynaptic potentials in the NTS but they are less effective than ? | |||||||||||||||
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Local injection of the opioid receptor antagonist naloxone, anti-Met-enkephalin or anti-? | |||||||||||||||
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RT-PCR revealed the expression of mu-, delta- and kappa-opioid receptor mRNAs in cultured adrenal chromaffin cells. | |||||||||||||||
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These results suggested that (1) Long-term administration of either peptide or non-peptide opioid agonist to cultured cell line produced a significant decrease of the gene expression of opioid receptor at transcription level. (2) The effect of peptide agonists was stronger and lasted longer than that of corresponding nonpeptide agonists. | |||||||||||||||
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The mu opioid receptor is robustly expressed in the ACC [54] and microinjection of morphine directly into the ACC reduced the affective component of pain [55]. | |||||||||||||||
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Opioid receptor antagonism and inhibition of opioid gene expression by a prodynorphin antisense phosphorothioate oligonucleotide blocked DMSO-induced cardiogenesis, suggesting an autocrine role of an opioid gene in developmental decisions. | |||||||||||||||
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