INT54296

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.06
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Spnb4)
Anatomy Link Frequency
neuronal 1
tail 1
Spnb4 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 2 98.80 Very High Very High Very High
Morphine 5 97.80 Very High Very High Very High
tail-flick 3 96.68 Very High Very High Very High
analgesia 2 80.28 Quite High
Versed 1 78.64 Quite High
Clonidine 1 78.12 Quite High
Dynorphin 2 75.00 Quite High
halothane 1 69.20 Quite High
anesthesia 30 68.40 Quite High
Eae 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 204 100.00 Very High Very High Very High
Dystonia 96 99.62 Very High Very High Very High
Metabolic Disorder 2 88.32 High High
Stuttering 4 76.24 Quite High
Congenital Anomalies 36 72.20 Quite High
Ataxia 18 51.80 Quite High
Cerebellar Diseases 2 46.52 Quite Low
Hyperuricemia 38 43.96 Quite Low
Cognitive Disorder 72 40.24 Quite Low
Syndrome 16 33.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first part of the study evaluated four nonvolatile general anesthetic agents in an attempt to obtain one that did not affect the antianalgesic action of Dyn A, the release of Dyn A, the analgesic action of i.t. morphine (inhibition of the tail-flick response) or the tail-flick latency by itself. alpha-Chloralose (120 mg/kg), urethane (1 g/kg) and pentobarbital (20 or 40 mg/kg) given i.p. did not meet one or more of these requirements.
Neg (not) Regulation (affect) of Dyn in tail associated with analgesic, tail-flick and morphine
1) Confidence 0.44 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7906735 Disease Relevance 0 Pain Relevance 0.89
Mutations resulting in little or no residual enzyme function typically cause classic LND, while mutations permitting residual activity more often lead to less severely affected LND variants.
Regulation (affected) of LND associated with disease
2) Confidence 0.27 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 0.65 Pain Relevance 0
By extrapolating from what is more clearly dystonia in more seriously affected classic LND cases, it seems likely that more mildly affected cases exemplify more subtle forms of dystonia.
Regulation (affected) of LND associated with dystonia and disease
3) Confidence 0.20 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 1.40 Pain Relevance 0
Although we cannot rule out that the molecular clock is affected in LNv and LNd pacemaker neurons, we favor the idea that Shaw mis-expression specifically effects neuronal clock output (see below and Discussion).


Regulation (affected) of LNd in neuronal
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0

General Comments

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