INT5430

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 4.58
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn8a) transmembrane transport (Scn8a)
Anatomy Link Frequency
brain 3
nerve 3
DRG 3
nervous system 2
RT4 2
Scn8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 212 100.00 Very High Very High Very High
tetrodotoxin 81 100.00 Very High Very High Very High
Spinal cord 33 99.56 Very High Very High Very High
Glutamate 21 99.56 Very High Very High Very High
Demyelination 27 99.46 Very High Very High Very High
Pain 96 99.40 Very High Very High Very High
Neuronal excitability 9 99.16 Very High Very High Very High
gABA 8 99.00 Very High Very High Very High
Inflammation 78 98.88 Very High Very High Very High
depression 44 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Demyelinating Disease 69 99.46 Very High Very High Very High
Pain 105 99.40 Very High Very High Very High
Injury 44 99.02 Very High Very High Very High
INFLAMMATION 99 98.88 Very High Very High Very High
Nervous System Injury 30 98.84 Very High Very High Very High
Spinal Cord Injury 76 98.42 Very High Very High Very High
Neuropathic Pain 51 98.08 Very High Very High Very High
Depression 44 97.60 Very High Very High Very High
Calcification 6 97.12 Very High Very High Very High
Pox Virus Infection 1 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From rat DRG we have cloned and functionally expressed a tetrodotoxin-sensitive sodium channel alpha subunit, NaCh6/Scn8a/rPN4, and a splice variant, rPN4a.
Gene_expression (expressed) of Scn8a in DRG associated with tetrodotoxin and sodium channel
1) Confidence 0.75 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9603190 Disease Relevance 0 Pain Relevance 0.30
Its increase in SCI animals might indicate injury-induced demyelination and/or an increase of the expression of sodium channels (particularly persistent Na+ channel) at the nodes, similarly as reported by Yoshimura and Groat [26] in afferents to urinary bladder, and observed by us in the sciatic nerve (unpublished observation).
Gene_expression (expression) of Na+ channel in sciatic nerve associated with demyelination, spinal cord injury, injury, sodium channel and sciatic nerve
2) Confidence 0.75 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2867983 Disease Relevance 0.62 Pain Relevance 0.26
These data show for the first time that Scn2a1, Scn3a, Scn5a, and Scn8a, as well as all VGSC beta subunits are expressed in the longitudinal smooth muscle layer of the rat myometrium.
Gene_expression (expressed) of Scn8a in myometrium
3) Confidence 0.73 Published 2007 Journal Biol. Reprod. Section Abstract Doc Link 17671266 Disease Relevance 0 Pain Relevance 0.37
Thus, in naïve animals, PN4 was abundantly expressed in brain, spinal cord, dorsal root ganglia (DRG) and peripheral nerve.
Gene_expression (expressed) of PN4 in spinal cord associated with spinal cord
4) Confidence 0.68 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10723066 Disease Relevance 0 Pain Relevance 0.78
Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene.
Gene_expression (expressed) of Na+ channel in skeletal muscle
5) Confidence 0.65 Published 1994 Journal J. Biol. Chem. Section Title Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.05
Using end-point and real-time quantitative RT-PCR, we detected the presence of the VGSC alpha subunits Scn2a1, Scn3a, Scn5a, and Scn8a in the cDNA from longitudinal muscle.
Gene_expression (presence) of Scn8a in longitudinal muscle
6) Confidence 0.64 Published 2007 Journal Biol. Reprod. Section Abstract Doc Link 17671266 Disease Relevance 0 Pain Relevance 0.38
Tissue distribution analyzed by RT-PCR showed NaCh6/Scn8a/rPN4 to be expressed at its highest levels in rat brain, at moderate levels in spinal cord, and at lower levels in DRG, nodose ganglia, and superior cervical ganglia and to be absent from sciatic nerve, heart, and skeletal muscle.
Neg (absent) Gene_expression (expressed) of Scn8a in superior associated with sciatic nerve and spinal cord
7) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9603190 Disease Relevance 0 Pain Relevance 0.34
The rat brain IIA Na+ channel alpha-subunit was expressed and studied in mammalian cells.
Gene_expression (expressed) of Na+ channel in brain
8) Confidence 0.58 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1309573 Disease Relevance 0.09 Pain Relevance 0.11
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
Gene_expression (expression) of Na+ channel in nerve associated with gaba and glutamate
9) Confidence 0.55 Published 2010 Journal J. Neurochem. Section Title Doc Link 20374421 Disease Relevance 0 Pain Relevance 0.95
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
Gene_expression (expression) of Na+ channel in nerve associated with gaba and glutamate
10) Confidence 0.48 Published 2010 Journal J. Neurochem. Section Title Doc Link 20374421 Disease Relevance 0 Pain Relevance 0.94
The results indicate that Na channel activity promotes basal prolactin secretion in male rat lactotropes and suggest that differences in Na channel expression contribute to explain the functional heterogeneity of these pituitary cells.
Gene_expression (expression) of Na channel in lactotropes
11) Confidence 0.40 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1659213 Disease Relevance 0 Pain Relevance 0.09
Based on Northern blot and ribonuclease protection experiments, RT4-B8 cells have been proposed to express rat cardiac Na channel mRNA as the major isoform.
Gene_expression (express) of Na channel in RT4
12) Confidence 0.39 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8967455 Disease Relevance 0 Pain Relevance 0.10
The results from both approaches were consistent, and not only demonstrated that individual neurons often express more than one LeNa isoform, but also revealed cell-specific patterns of Na channel isoform expression in the leech nervous system.
Gene_expression (expression) of Na channel in nervous system
13) Confidence 0.37 Published 2003 Journal J. Neurobiol. Section Abstract Doc Link 12717704 Disease Relevance 0 Pain Relevance 0.14
Aims of studies reported here were to examine the effect of salicylamide on the incorporation of radiosulfate into glycosaminoglycans (GAGs) and the biosynthesis of chondroitin 4-sulfate (Ch-4-S) and chondroitin 6-sulfate (Ch-6-S) in fetal rat limbs was studied.
Gene_expression (biosynthesis) of Ch-6-S in limbs
14) Confidence 0.37 Published 1981 Journal Drug Nutr Interact Section Abstract Doc Link 6821388 Disease Relevance 0.13 Pain Relevance 0.09
The results showed that with increasing gestational age, there was an increase in synthesis of Ch-4-S with a concomitant decrease in synthesis of Ch-6-S.
Gene_expression (synthesis) of Ch-6-S
15) Confidence 0.37 Published 1981 Journal Drug Nutr Interact Section Abstract Doc Link 6821388 Disease Relevance 0.40 Pain Relevance 0
We report here direct electrophysiological evidence that the expressed voltage-gated Na channels in the RT4-B8 cell line are of the cardiac phenotype with no evidence for subpopulations expressing other Na channel isoforms.
Gene_expression (expressing) of Na channel in RT4
16) Confidence 0.35 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8967455 Disease Relevance 0 Pain Relevance 0.12
The majority of Na channels in the heart are composed of the tetrodotoxin (TTX)-resistant (KD, 2 to 6 micromol/L) "cardiac" NaV1.5 isoform; however, TTX-sensitive (KD, 1 to 25 nmol/L) "neuronal" Na channel isoforms have recently been detected in several cardiac preparations.
Gene_expression (detected) of Na channel in neuronal associated with tetrodotoxin
17) Confidence 0.29 Published 2006 Journal Circ. Res. Section Abstract Doc Link 16484618 Disease Relevance 0 Pain Relevance 0.62
Thus, in naïve animals, PN4 was abundantly expressed in brain, spinal cord, dorsal root ganglia (DRG) and peripheral nerve.
Gene_expression (expressed) of PN4 in dorsal root ganglia associated with spinal cord
18) Confidence 0.23 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10723066 Disease Relevance 0 Pain Relevance 0.78
Thus, in naïve animals, PN4 was abundantly expressed in brain, spinal cord, dorsal root ganglia (DRG) and peripheral nerve.
Gene_expression (expressed) of PN4 in brain associated with spinal cord
19) Confidence 0.23 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10723066 Disease Relevance 0 Pain Relevance 0.78
Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene.
Gene_expression (expressed) of Na+ channel in heart
20) Confidence 0.22 Published 1994 Journal J. Biol. Chem. Section Title Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.05

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