INT54302

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2011
Negated 8
Speculated 1
Reported most in Body
Documents 126
Total Number 127
Disease Relevance 86.18
Pain Relevance 30.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cell 26
Th2 cells 8
alternatively activated macrophages 6
spleen 5
macrophages 4
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2602 100.00 Very High Very High Very High
Inflammation 1483 100.00 Very High Very High Very High
Central nervous system 54 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Enkephalin 7 99.86 Very High Very High Very High
substance P 1 99.76 Very High Very High Very High
tolerance 116 99.40 Very High Very High Very High
Arthritis 564 99.28 Very High Very High Very High
qutenza 11 99.08 Very High Very High Very High
rheumatoid arthritis 554 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1588 100.00 Very High Very High Very High
Infection 862 100.00 Very High Very High Very High
Sprains And Strains 572 100.00 Very High Very High Very High
Targeted Disruption 386 100.00 Very High Very High Very High
Cold Sores 219 100.00 Very High Very High Very High
Parasitic Infection 21 99.98 Very High Very High Very High
Eosinophilia 58 99.90 Very High Very High Very High
Thymoma 4 99.86 Very High Very High Very High
Asthma 1518 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 851 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CNS delivery of the d120:LacZ:IL-4 vector, after EAE onset, induced the in situ production of IL-4 by CNS-resident cells facing the cerebrospinal fluid (CSF) spaces and reduced by 47% (P < 0.02) the disease-related deaths.
Positive_regulation (induced) of Gene_expression (production) of IL-4 in cerebrospinal fluid associated with multiple sclerosis, central nervous system and disease
1) Confidence 0.68 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11402297 Disease Relevance 2.04 Pain Relevance 0.69
Recently, we identified a novel sphingomyelinase-like activity in the saliva of I. scapularis that is capable of inducing IL-4 expression in the adoptive transfer model system used in this study.
Positive_regulation (inducing) of Gene_expression (expression) of IL-4 in saliva
2) Confidence 0.56 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0 Pain Relevance 0
Dermacentor andersoni also induced expression of IL-4 in skin.
Positive_regulation (induced) of Gene_expression (expression) of IL-4 in skin
3) Confidence 0.56 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.11 Pain Relevance 0.04
In contrast to most studies examining polyclonal T cell responses to ticks or tick derived molecules [4], the increase in IL-4 expression was not accompanied by reduced expression of the Th1 cytokine IFN-?
Positive_regulation (increase) of Gene_expression (expression) of IL-4 in T cell associated with cytokine
4) Confidence 0.56 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.40 Pain Relevance 0.18
In the present study, infestation with the metastriate tick, D. andersoni, induced CD4+ T cell expression of IL-4 at levels comparable to that stimulated by feeding of I. scapularis nymphs [22].
Positive_regulation (induced) of Gene_expression (expression) of IL-4 in T cell
5) Confidence 0.56 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.16 Pain Relevance 0.13
In these mice, progression to diabetes was still prevented after B:9-23/IFA treatment, suggesting that IL-4 production is not necessary for achieving tolerance.
Neg (not) Positive_regulation (necessary) of Gene_expression (production) of IL-4 associated with diabetes mellitus and tolerance
6) Confidence 0.56 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.33 Pain Relevance 0.23
Since this effect was not found with purified B cells and no enhancement of IL-4 receptor expression on B cells could be observed, we studied the effect of beta-End on IL-4 production.
Neg (no) Positive_regulation (enhancement) of Gene_expression (expression) of IL-4 in B cells
7) Confidence 0.52 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8099850 Disease Relevance 0 Pain Relevance 0.09
Morphine treatment in wild type splenocytes inhibited IFN gamma and stimulated IL-4 protein synthesis.
Positive_regulation (stimulated) of Gene_expression (synthesis) of IL-4
8) Confidence 0.51 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
Together, these results provide convincing support for the specificity of smooth muscle cell disruption of IL-4R?
Positive_regulation (support) of Gene_expression (disruption) of IL-4 in smooth muscle cell
9) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.51 Pain Relevance 0
Interestingly, the cytokines IL-4 and IL-13 drive differentiation into alternatively activated macrophages through IL-4R?
Positive_regulation (through) of Gene_expression (drive) of IL-4 in alternatively activated macrophages associated with cytokine
10) Confidence 0.49 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.17 Pain Relevance 0.39
Generation and genotyping of conditional IL-4R?
Positive_regulation (Generation) of Gene_expression (Generation) of IL-4
11) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.43 Pain Relevance 0.09
Interestingly, the cytokines IL-4 and IL-13 drive differentiation into alternatively activated macrophages through IL-4R?
Positive_regulation (alternatively activated macrophages) of Gene_expression (drive) of IL-4 in alternatively activated macrophages associated with cytokine
12) Confidence 0.49 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.17 Pain Relevance 0.39
/lox mice as by day 10 PI in goblet cell hyperplasia was comparable to levels observed in IL-4R??
Positive_regulation (observed) of Gene_expression (observed) of IL-4 in goblet cell associated with hyperplasia
13) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.69 Pain Relevance 0.03
Together, these data are suggestive of smooth muscle IL-4R?
Positive_regulation (smooth muscle) of Gene_expression (suggestive) of IL-4 in smooth muscle
14) Confidence 0.49 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.48 Pain Relevance 0.18
in thymoma cells induced IL-4 gene expression and decreased IFN-?
Positive_regulation (induced) of Gene_expression (expression) of IL-4 associated with thymoma
15) Confidence 0.47 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.10 Pain Relevance 0.11
The treatment with a single dose of inactivated Candida blastospores induced interleukin-2(IL-2), interferon-gamma (IFNgamma) and interleukin-4 (IL-4) production at 24 h after in vitro restimulation of splenocytes.
Positive_regulation (induced) of Gene_expression (production) of IL-4
16) Confidence 0.46 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.33 Pain Relevance 0.57
Third, and perhaps most importantly, in oxazolone-induced colitis, the T cell response is accompanied by markedly elevated IL-4 production and prevented by the systemic co-administration of anti-IL4 antibody (15).
Positive_regulation (elevated) of Gene_expression (production) of IL-4 in T cell associated with colitis
17) Confidence 0.45 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.75 Pain Relevance 0.28
Experiments undertaken to reveal the mechanism of action of opioid peptides suggest an overall enhancement of lymphokine production: (1) enhancement of IL-4 production occurred also in the presence of excess IL-2; and (2) neither IL-1 receptor-antagonizing protein nor anti-IL-6 were capable to abrogate the stimulatory effect on IL-2 and IL-4 production.
Positive_regulation (enhancement) of Gene_expression (production) of IL-4 associated with opioid
18) Confidence 0.43 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.78
levels were downgraded and IL-4 levels were upregulated in different degrees, and the ratios of IFN-?
Positive_regulation (upregulated) of Gene_expression (levels) of IL-4
19) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.38 Pain Relevance 0
NAC also abrogated APAP-induced increases in TNFalpha, KC/gro, and IL-10, but augmented expression of the anti-inflammatory cytokines interleukin-4 (IL-4) and transforming growth factor-beta (TGFbeta).
Positive_regulation (augmented) of Gene_expression (expression) of anti-inflammatory cytokines interleukin-4 associated with paracetamol, inflammation and cytokine
20) Confidence 0.39 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.29 Pain Relevance 1.10

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