INT5432

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.87
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Atp7b) cytoplasmic membrane-bounded vesicle (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
spinal 1
spinal cord 1
brain stem 1
Atp7b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 7 99.72 Very High Very High Very High
Migraine 1 99.00 Very High Very High Very High
antagonist 2 98.96 Very High Very High Very High
substance P 6 98.72 Very High Very High Very High
Opioid 1 98.68 Very High Very High Very High
GABAergic 1 97.60 Very High Very High Very High
Sumatriptan 2 97.16 Very High Very High Very High
Triptan 2 96.04 Very High Very High Very High
agonist 6 95.12 Very High Very High Very High
Spinal cord 4 91.28 High High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 2 100.00 Very High Very High Very High
Headache 1 99.00 Very High Very High Very High
Targeted Disruption 3 98.54 Very High Very High Very High
Repression 1 98.00 Very High Very High Very High
Pox Virus Infection 2 97.16 Very High Very High Very High
Infection 2 67.04 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study regulation of the preprotachykinin-A gene promoter, we utilised a biolistic gene transfer protocol to deliver a DNA construct that incorporates a portion of the preprotachykinin-A gene promoter and an enhanced green fluorescent protein reporter gene into neonatal rat spinal cord organotypic slices.
Regulation (regulation) of gene promoter in spinal cord associated with spinal cord
1) Confidence 0.36 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16893415 Disease Relevance 0 Pain Relevance 0.26
These data suggest a modulated activity of the preprotachykinin-A gene promoter in spinal neurones in vitro by substance P and/or neurotrophins.
Regulation (modulated) of gene promoter in spinal associated with substance p
2) Confidence 0.26 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16893415 Disease Relevance 0 Pain Relevance 0.46
The chimeric genes have been expressed in tobacco plants under the control of the seed-specific napA gene promoter.
Regulation (control) of seed-specific napA gene promoter
3) Confidence 0.18 Published 2001 Journal Plant Mol. Biol. Section Abstract Doc Link 11575727 Disease Relevance 0.16 Pain Relevance 0.17
As controls, CMV promoter activity was not affected, and 5-HT(1B/D) receptor antagonists blocked the repression caused by sumatriptan and eletriptan.
Neg (not) Regulation (affected) of CMV promoter associated with sumatriptan, antagonist, repression and cytomegalovirus infection
4) Confidence 0.01 Published 2004 Journal Brain Res. Section Abstract Doc Link 14715155 Disease Relevance 0.45 Pain Relevance 1.00
Because RNA synthesis probably occurs without major differences in the cytoplasm of all infected cell types under the control of the T7 promoter and T7 polymerase, we conclude that cell type-specific expression of the Na+ channel probably reflects differences at posttranslational steps.
Regulation (control) of T7 promoter
5) Confidence 0.01 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1309573 Disease Relevance 0.07 Pain Relevance 0.11
Whole cell recordings were made from NTS and DMV neurons in brain stem slices from rats and transgenic mice that expressed enhanced green fluorescent protein (EGFP) under the control of a GAD67 promoter (EGFP-GABA neurons) to identify opioid-mediated effects on GABAergic circuitry.
Regulation (control) of GAD67 promoter in brain stem associated with targeted disruption, gaba, gabaergic and opioid
6) Confidence 0.01 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17615134 Disease Relevance 0.10 Pain Relevance 0.54
Cells were infected with a recombinant vaccinia virus (VV) carrying the bacteriophage T7 RNA polymerase gene and were transfected with cDNA encoding the IIA Na+ channel alpha-subunit under control of a T7 promoter.
Regulation (control) of T7 promoter associated with pox virus infection
7) Confidence 0.00 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1309573 Disease Relevance 0.10 Pain Relevance 0.11

General Comments

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