INT5433

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Context Info
Confidence 0.03
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.20
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
A549 1
polymerase (Homo sapiens)
polymerase - M204I (1)
Pain Link Frequency Relevance Heat
Potency 4 83.16 Quite High
sodium channel 1 75.00 Quite High
tetrodotoxin 1 75.00 Quite High
Inflammation 22 49.60 Quite Low
anesthesia 4 46.40 Quite Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 31 100.00 Very High Very High Very High
Trepenoma Infection 223 99.00 Very High Very High Very High
Sprains And Strains 54 96.96 Very High Very High Very High
Weight Loss 8 96.44 Very High Very High Very High
Alopecia 4 95.12 Very High Very High Very High
Lung Cancer 6 94.82 High High
Cytomegalovirus Infection 120 91.52 High High
Neutropenia 4 90.76 High High
Disorders Of Creatine Metabolism 9 89.84 High High
Infection 79 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro viral polymerase activity
Regulation (vitro) of polymerase
1) Confidence 0.03 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0.51 Pain Relevance 0
Furthermore, its signature resistance mutation (a change from methionine to isoleucine at position 204 in the reverse transcriptase domain of the hepatitis B polymerase) also confers cross-resistance to entecavir, lamivudine, and emtricitabine.
Regulation (change) of polymerase (M204I) associated with hepatitis
2) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2762437 Disease Relevance 0.79 Pain Relevance 0.04
Effect of observed mutations on viral polymerase activity, receptor specificity, and antigenicity.
Regulation (Effect) of polymerase
3) Confidence 0.02 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.25 Pain Relevance 0
A549 cells cultured in 24-well tissue culture plates were co-transfected with pPol1-NS-Renilla (100 ng) encoding a reporter mini-genome under transcriptional control of the human RNA polymerase I, pSV-Luc (200 ng) encoding firefly luciferase under SV40 virus RNA polymerase II promoter control, and four plasmids expressing viral PB2, PB1, PA, NP (50 ng each) from the strain of interest.
Regulation (control) of polymerase in A549 associated with lung cancer and sprains and strains
4) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0.32 Pain Relevance 0
A 10┬Ál sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Regulation (targets) of polymerase
5) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods.
Regulation (target) of polymerase in blood associated with trepenoma infection
6) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2872645 Disease Relevance 1.05 Pain Relevance 0
Following intracellular phosphorylation to the diphosphate form by host kinases, cidofovir targets the viral DNA polymerase by acting as a chain terminator.
Regulation (targets) of polymerase
7) Confidence 0.01 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861935 Disease Relevance 1.12 Pain Relevance 0
Because RNA synthesis probably occurs without major differences in the cytoplasm of all infected cell types under the control of the T7 promoter and T7 polymerase, we conclude that cell type-specific expression of the Na+ channel probably reflects differences at posttranslational steps.
Regulation (control) of T7 polymerase
8) Confidence 0.00 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1309573 Disease Relevance 0.07 Pain Relevance 0.11

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