INT54331

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.55
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
plasma 1
passage cells 1
MACH 1
muscle 1
extracellular matrix 1
Glul (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 46 100.00 Very High Very High Very High
Opioid 16 99.92 Very High Very High Very High
Paracetamol 10 99.08 Very High Very High Very High
monoamine 8 97.48 Very High Very High Very High
Cannabinoid 3 97.32 Very High Very High Very High
Cannabinoid receptor 1 95.60 Very High Very High Very High
agonist 2 89.28 High High
Enkephalin 2 79.20 Quite High
cva 2 76.08 Quite High
cytokine 22 71.76 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 69 97.62 Very High Very High Very High
Hypertrophy 6 96.96 Very High Very High Very High
Penetrating Head Injuries 10 95.06 Very High Very High Very High
Hyperammonemia 8 94.88 High High
Gliosis 4 94.64 High High
Injury 110 93.80 High High
Stab Wounds 30 93.52 High High
Aggression 2 92.40 High High
Hepatic Encephalopathy 46 87.04 High High
Congenital Anomalies 2 79.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GS activity was markedly increased in MACH cultures grown in the presence of opioids with no changes in CNP.
Positive_regulation (increased) of GS in MACH associated with opioid
1) Confidence 0.67 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7908340 Disease Relevance 0.07 Pain Relevance 0.75
In the late passage cells, already committed to astrocytic expression, opioid treatment enhanced GS activity suggesting that astrocytes respond to opioids.
Positive_regulation (enhanced) of GS in passage cells associated with opioid
2) Confidence 0.59 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7908340 Disease Relevance 0.07 Pain Relevance 0.75
We suggest several possible mechanisms to explain these findings such as a differential involvement of a Gs and a Gi protein activated at low and high doses, respectively, allosteric modulation of the cannabinoid, and activation of presynaptic cannabinoid receptors by low doses of anandamide.
Positive_regulation (activated) of Gs associated with cannabinoid receptor and cannabinoid
3) Confidence 0.44 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476980 Disease Relevance 0.23 Pain Relevance 0.20
In addition, hepatic glutamine synthetase activities were lower, and plasma ammonia levels were elevated in mice given hepatotoxic doses of acetaminophen.
Positive_regulation (elevated) of glutamine synthetase in plasma associated with paracetamol
4) Confidence 0.42 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9344900 Disease Relevance 0.25 Pain Relevance 0.66
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Positive_regulation (induction) of glutamine synthetase in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
5) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.91 Pain Relevance 0.18
However, the induction of chondroitin sulfate proteoglycans, tenascin, S-100B as well as glutamate transporter proteins, GLAST and GLT-1, and glutamine synthetase are independent of IL-1RI signaling.
Positive_regulation (induction) of glutamine synthetase associated with glutamate
6) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1533808 Disease Relevance 0.74 Pain Relevance 0.09
In well-nourished cirrhotic patients, the affected liver has an impaired capacity for removal of ammonia in the form of urea, which may result in increased muscle glutamine synthetase in order to provide an alternative mechanism for ammonia removal as glutamine.
Positive_regulation (increased) of glutamine synthetase in muscle associated with cirrhosis
7) Confidence 0.11 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 1.27 Pain Relevance 0
This Gs-coupled receptor has tantalizing pharmacology and can be activated, at least in vitro, by trace amines, amphetamines and several monoamine metabolites [18], [19].
Positive_regulation (activated) of Gs-coupled receptor associated with monoamine
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0 Pain Relevance 0.12

General Comments

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