INT54364

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Context Info
Confidence 0.53
First Reported 1993
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.15
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
ileum 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 26 100.00 Very High Very High Very High
narcan 14 99.36 Very High Very High Very High
analgesia 8 98.70 Very High Very High Very High
Spinal cord 3 98.68 Very High Very High Very High
Analgesic 6 98.28 Very High Very High Very High
antidepressant 3 97.64 Very High Very High Very High
antagonist 4 86.48 High High
Antinociceptive 5 82.88 Quite High
Hyperalgesia 2 77.60 Quite High
agonist 1 58.24 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 77.60 Quite High
Stress 1 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of enkephalin associated with analgesic, narcan, enkephalin and analgesia
1) Confidence 0.53 Published 1994 Journal Neuropharmacology Section Title Doc Link 7910383 Disease Relevance 0.08 Pain Relevance 1.49
This hypothesis was investigated by using the systemically active mixed inhibitor of enkephalin degrading enzymes, RB 101.
Negative_regulation (inhibitor) of Protein_catabolism (degrading) of enkephalin associated with enkephalin
2) Confidence 0.39 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.08 Pain Relevance 0.88
Spinorphin, a potent inhibitor of enkephalin degrading enzyme isolated from the bovine spinal cord, produces a dose-related inhibition of electrically evoked contractions of both MVD (mouse vas deferens) and GPI (guinea-pig ileum).
Negative_regulation (inhibitor) of Protein_catabolism (degrading) of enkephalin in ileum associated with enkephalin and spinal cord
3) Confidence 0.21 Published 1993 Journal Masui Section Abstract Doc Link 8267798 Disease Relevance 0 Pain Relevance 0.38
Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice.
Negative_regulation (inhibitor) of Protein_catabolism (degrading) of enkephalin associated with antidepressant and enkephalin
4) Confidence 0.09 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539320 Disease Relevance 0 Pain Relevance 0.39

General Comments

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