INT54369

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.03
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VTA1) endosome (VTA1) cytoplasm (VTA1)
Anatomy Link Frequency
DA neurons 1
brainstem 1
VTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 36 100.00 Very High Very High Very High
Nucleus accumbens 26 99.90 Very High Very High Very High
Dopamine 41 99.62 Very High Very High Very High
agonist 3 99.18 Very High Very High Very High
opioid receptor 6 99.00 Very High Very High Very High
Kappa opioid receptor 1 98.50 Very High Very High Very High
midbrain 15 97.88 Very High Very High Very High
addiction 54 97.36 Very High Very High Very High
medulla 5 96.36 Very High Very High Very High
Locus ceruleus 13 94.92 High High
Disease Link Frequency Relevance Heat
Depression 304 99.96 Very High Very High Very High
Anxiety Disorder 41 99.28 Very High Very High Very High
Disease 13 98.38 Very High Very High Very High
Recurrence 11 97.84 Very High Very High Very High
Opiate Addiction 34 93.56 High High
Congenital Anomalies 81 85.04 High High
Substance Withdrawal Syndrome 8 79.28 Quite High
Unconsciousness 56 72.32 Quite High
Hypertrophy 6 68.88 Quite High
Cognitive Disorder 14 68.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered FA has been previously shown in brainstem nuclei in the presence of known neuronal loss, including altered FA in the SN in Parkinson's Disease [e.g. [65], [66]], confirming the potential for FA to detect pathology-relevant changes in the VTA/SN region.
Regulation (changes) of VTA/SN in brainstem associated with medulla and disease
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993928 Disease Relevance 0.70 Pain Relevance 0.07
In contrast, trait anxiety scores (STAI-T) were significantly different between abnormal and normal VTA/SN MDD subgroups [t(2,19)?
Regulation (different) of VTA/SN associated with depression and anxiety disorder
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993928 Disease Relevance 0.98 Pain Relevance 0.07
The excitatory cortical pathways may produce little response in the VTA during the resting state, leading to reductions in DA.
Neg (little) Spec (may) Regulation (response) of VTA associated with ventral tegmentum and dopamine
3) Confidence 0.18 Published 2002 Journal Sci Pract Perspect Section Body Doc Link PMC2851054 Disease Relevance 0.65 Pain Relevance 1.23
Evaluating midbrain mu- and kappa-opioid receptors, relevant for the action of heroin and regulation of DA neurons, revealed dysregulation of G-protein coupling selective to the VTA PN.
Regulation (dysregulation) of VTA PN in DA neurons associated with ventral tegmentum, dopamine, kappa opioid receptor and midbrain
4) Confidence 0.09 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.39 Pain Relevance 0.78
The NAc and VTA are especially sensitive to rewarding stimuli [63].
Regulation (sensitive) of VTA associated with ventral tegmentum and nucleus accumbens
5) Confidence 0.05 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.30 Pain Relevance 0.38
Similar doses of these opioid receptor agonists injected into LH-MFB had no significant effect on the self-stimulation rates of either LH-MFB or VTA-SN.
Neg (no) Regulation (effect) of VTA-SN associated with agonist and opioid receptor
6) Confidence 0.01 Published 1994 Journal Physiol. Behav. Section Abstract Doc Link 7910690 Disease Relevance 0 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox