INT54370

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.06
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VTA1) endosome (VTA1) cytoplasm (VTA1)
Anatomy Link Frequency
dopamine neurons 2
neuronal 1
VTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 17 100.00 Very High Very High Very High
GABAergic 3 100.00 Very High Very High Very High
opiate 11 99.98 Very High Very High Very High
Dopamine 29 99.96 Very High Very High Very High
Nucleus accumbens 17 99.80 Very High Very High Very High
cocaine 9 98.70 Very High Very High Very High
addiction 14 98.48 Very High Very High Very High
Nicotine 64 98.20 Very High Very High Very High
opioid receptor 6 98.00 Very High Very High Very High
agonist 3 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 57 99.10 Very High Very High Very High
Opiate Addiction 1 98.76 Very High Very High Very High
Depression 118 96.96 Very High Very High Very High
Myelodysplastic Syndromes 32 92.44 High High
Stress 6 85.12 High High
Adhesions 1 76.36 Quite High
Congenital Anomalies 37 75.76 Quite High
Convulsion 2 66.08 Quite High
Febrile Convulsions 1 62.08 Quite High
Disease 5 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Russo and colleagues have shown that chronic drug use leads to a reduction in neuronal size in the VTA in an animal model of chronic opiate addiction [82].
Negative_regulation (reduction) of VTA in neuronal associated with addiction and opiate
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993928 Disease Relevance 1.05 Pain Relevance 0.41
Only 3 SNPs were associated with sleepiness at p < 0.001 by both approaches; these were located in FHIT, VTA1, and LRP1B.
Negative_regulation (located) of VTA1 associated with sleep disorders
2) Confidence 0.18 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995620 Disease Relevance 0.40 Pain Relevance 0.08
For example, stimulants such as amphetamines and cocaine directly increase dopaminergic transmission in the NAc; opiates inhibit GABAergic interneurons in the VTA by disinhibiting VTA dopamine neurons projecting to the NAc; and nicotine seems to activate VTA dopamine neurons both directly and indirectly via stimulation of glutamatergic terminals innervating dopamine cells (Nestler 2005; Lüscher & Ungless 2006).
Negative_regulation (disinhibiting) of VTA in dopamine neurons associated with ventral tegmentum, nucleus accumbens, dopamine, nicotine, gabaergic, opiate and cocaine
3) Confidence 0.03 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0.30 Pain Relevance 0.82
For example, stimulants such as amphetamines and cocaine directly increase dopaminergic transmission in the NAc; opiates inhibit GABAergic interneurons in the VTA by disinhibiting VTA dopamine neurons projecting to the NAc; and nicotine seems to activate VTA dopamine neurons both directly and indirectly via stimulation of glutamatergic terminals innervating dopamine cells (Nestler 2005; Lüscher & Ungless 2006).
Negative_regulation (inhibit) of VTA in dopamine neurons associated with ventral tegmentum, nucleus accumbens, dopamine, nicotine, gabaergic, opiate and cocaine
4) Confidence 0.03 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0.31 Pain Relevance 0.82
These microinjections did not alter the self-stimulation of LH-MFB when effects of these injections were still persisting in VTA-SN.
Negative_regulation (persisting) of VTA-SN
5) Confidence 0.02 Published 1994 Journal Physiol. Behav. Section Abstract Doc Link 7910690 Disease Relevance 0 Pain Relevance 0.64

General Comments

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