INT54375

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Context Info
Confidence 0.03
First Reported 1993
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ap1m2) vesicle-mediated transport (Ap1m2) Golgi apparatus (Ap1m2)
Anatomy Link Frequency
brain 1
Ap1m2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.92 Very High Very High Very High
antinociception 7 99.50 Very High Very High Very High
Morphine 13 99.00 Very High Very High Very High
Intracerebroventricular 1 99.00 Very High Very High Very High
Potency 2 98.62 Very High Very High Very High
analgesia 5 98.36 Very High Very High Very High
Analgesic 4 97.08 Very High Very High Very High
intrathecal 3 94.56 High High
Opioid 3 89.36 High High
antagonist 1 88.48 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to determine if the highly mu-selective compound etonitazene could produce supraspinal (intracerebroventricular; i.c.v.) antinociception in CXBK mice, which are deficient in brain mu1, but not mu2, opioid receptors.
Negative_regulation (deficient) of mu2 in brain associated with antinociception, opioid receptor and intracerebroventricular
1) Confidence 0.03 Published 1994 Journal Life Sci. Section Abstract Doc Link 7910928 Disease Relevance 0 Pain Relevance 1.06
The mu1-selective drug naloxonazine (35 mg/kg s.c.) antagonizes the analgesic actions of morphine given only supraspinally without diminishing the potency of i.c.v. morphine in the synergy model. beta-Funaltrexamine, which blocks both mu1 and mu2 receptors, given i.c.v. antagonizes the analgesia after supraspinal morphine alone (ID50 2.5 micrograms i.c.v.) or its potentiation of intrathecal morphine (ID50 2.4 micrograms i.c.v.) equally well, confirming the involvement of mu receptors in both actions.
Negative_regulation (blocks) of mu2 associated with analgesic, intrathecal, analgesia, potency and morphine
2) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8386234 Disease Relevance 0.22 Pain Relevance 1.91

General Comments

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