INT54449

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
BNP 2
striatum 2
brainstem 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 11 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
Morphine 4 99.70 Very High Very High Very High
withdrawal 11 99.26 Very High Very High Very High
Raphe magnus 3 97.08 Very High Very High Very High
medulla 1 96.20 Very High Very High Very High
Pain 9 95.68 Very High Very High Very High
addiction 4 94.56 High High
anesthesia 1 93.72 High High
isoflurane 1 93.28 High High
Disease Link Frequency Relevance Heat
Pain 7 95.68 Very High Very High Very High
Opiate Addiction 5 94.56 High High
Natriuresis 5 88.88 High High
Coronary Heart Disease 4 82.12 Quite High
Drug Dependence 2 80.28 Quite High
Fibrosis 2 77.52 Quite High
Low Back Pain 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Transcription (expression) of NPR in BNP
1) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
In this study, we demonstrate that withdrawal from chronic morphine significantly upregulates the mRNA level of adenylyl cyclase (AC) VI and VIII isoforms and immunoreactivity of ACV/VI in the nucleus raphe magnus (NRM), a brainstem site critically involved in opioid modulation of pain.
Positive_regulation (upregulates) of Transcription (level) of cyclase in brainstem associated with pain, medulla, raphe magnus, opioid, withdrawal and morphine
2) Confidence 0.43 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15829634 Disease Relevance 0.91 Pain Relevance 2.05
This study was designed to evaluate the effects of a chronic treatment with the classical neuroleptic drug haloperidol on the preproenkephalin (ppEnk) mRNA synthesis and its consequences for opioid and dopamine (DA) receptor-regulated adenylate cyclase in the developing and adult rat striatum.
Positive_regulation (receptor-regulated) of Transcription (synthesis) of cyclase in striatum associated with dopamine and opioid
3) Confidence 0.05 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.50

General Comments

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