INT54458

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.88
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
cortex 2
muscle cells 1
developmental stages 1
brain 1
ganglia 1
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 14 100.00 Very High Very High Very High
Potency 1 99.92 Very High Very High Very High
antagonist 4 99.60 Very High Very High Very High
Glutamate 2 99.36 Very High Very High Very High
Glutamate receptor 1 99.36 Very High Very High Very High
Nicotine 25 99.34 Very High Very High Very High
Codeine 1 97.26 Very High Very High Very High
Antinociceptive 3 96.78 Very High Very High Very High
tetrodotoxin 1 96.08 Very High Very High Very High
qutenza 2 93.80 High High
Disease Link Frequency Relevance Heat
Pheochromocytoma 1 100.00 Very High Very High Very High
Reprotox - General 1 1 99.92 Very High Very High Very High
Nociception 2 88.92 High High
Pain 6 86.68 High High
Anxiety Disorder 6 75.00 Quite High
Cognitive Disorder 4 75.00 Quite High
Neuropathic Pain 2 68.40 Quite High
Vomiting 2 25.00 Low Low
Headache 2 25.00 Low Low
Arthralgia 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with glutamate antagonists did not reveal any interaction between nAChR and ionotropic glutamate receptors.
nAChR Neg (not) Binding (interaction) of associated with glutamate, glutamate receptor and antagonist
1) Confidence 0.36 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044734 Disease Relevance 0 Pain Relevance 0.54
5-[(1R,5S)-3,6-Diazabicyclo[3.2.0]heptan-6-yl]nicotinonitrile (A-366833) is a novel nicotinic acetylcholine receptor (nAChR) ligand that binds to the agonist-binding site ([3H]-cytisine) with Ki value of 3.1 nM and exhibits agonist selectivity at alpha4beta2 nAChR relative to the alpha3beta4 nAChR subtype.
nAChR Binding (binds) of associated with agonist
2) Confidence 0.34 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17854775 Disease Relevance 0.21 Pain Relevance 0.51
The compound was approximately 5000-fold less potent (Ki = 230nM) in the displacement of [125I] alpha-bungarotoxin binding from the alpha-bungarotoxin-sensitive nAChR subtype present in rat brain but was a potent inhibitor (Ki, 2.7 nM) of [125I] alpha-bungarotoxin binding to the nAChR subtype in Torpedo electroplax, which is similar to that present in the neuromuscular junction.
nAChR Binding (binding) of in neuromuscular junction
3) Confidence 0.32 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965777 Disease Relevance 0 Pain Relevance 0.25
Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.

(+/-)-Epibatidine (EPIB) and A-85380 are nicotinic acetylcholine receptor (nAChR) agonists that bind to the agonist ([3H]cytisine) binding site with 40 to 50 pM affinity but have different affinities in nAChR subtype selective functional receptor assays.

nAChR Binding (bind) of associated with agonist and antinociceptive
4) Confidence 0.29 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9864263 Disease Relevance 0.26 Pain Relevance 0.74
This study sought to establish whether (+/-)-epibatidine, like (-)-nicotine, also displays a wide diversity of behavioral responses that are known to be elicited by nAChR activation or whether it demonstrates subtype selectivity for its interactions with nAChRs.(+/-)-Epibatidine displaced [3H](-)-cytisine binding to the alpha 4 beta 2 nAChR subtype in rat brain membranes with high affinity (Ki, 43 pM).
nAChR Binding (binding) of in brain associated with nicotine
5) Confidence 0.28 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965777 Disease Relevance 0 Pain Relevance 0.16
Here, we have investigated the occurrence of the ligand-binding alpha-subunits of neuronal nAChR by means of reverse transcription/polymerase chain reaction and immunohistochemistry in the rat heart during prenatal and postnatal development and after capsaicin-induced sensory denervation. mRNAs coding for the alpha4, alpha5, alpha7 and alpha10 subunits were detected throughout all developmental stages.
nAChR Binding (binding) of in developmental stages associated with qutenza
6) Confidence 0.23 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15549397 Disease Relevance 0 Pain Relevance 0.09
There was no significant change in ligand binding for nicotinic acetylcholine receptor (nAChR) associated with treatment with the chemical alone; a combination of PB and DEET or coexposure with PB, DEET, and permethrin caused a significant increase in nAChR ligand binding in the cortex.
nAChR Binding (binding) of in cortex
7) Confidence 0.15 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11248143 Disease Relevance 0 Pain Relevance 0.32
The alkaloids (-)physostigmine (Phy), galanthamine (Gal) and codeine (Cod), and several derivatives and homologous compounds, can act as noncompetitive agonists (NCA) of nicotinic acetylcholine receptors (nAChR) from Torpedo electrocytes, frog and mammalian muscle cells, clonal rat pheochromocytoma cells, cultured hippocampal neurons and several ectopic expression systems, by interacting with a binding site on the alpha-subunits of these nAChRs that is insensitive to the natural transmitter, acetylcholine (ACh), and ACh-competitive agonists and antagonists.
nAChR Binding (interacting) of in muscle cells associated with antagonist, agonist, pheochromocytoma and codeine
8) Confidence 0.14 Published 1995 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 8903949 Disease Relevance 0.10 Pain Relevance 0.44
There was no significant change in ligand binding for nicotinic acetylcholine receptor (nAChR) associated with treatment with the chemical alone; a combination of PB and DEET or coexposure with PB, DEET, and permethrin caused a significant increase in nAChR ligand binding in the cortex.
nAChR Binding (binding) of in cortex
9) Confidence 0.10 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11248143 Disease Relevance 0 Pain Relevance 0.27
Compared to (-)-nicotine, ABT 418 has reduced potency to interact with the subunit isoforms of nAChR found in sympathetic ganglia, and it does not compete for alpha-bungarotoxin binding sites in brain or at the neuromuscular junction.
nAChR Binding (interact) of in ganglia associated with nicotine, reprotox - general 1 and potency
10) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7913497 Disease Relevance 0.31 Pain Relevance 0.26

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