INT54460

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Context Info
Confidence 0.03
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Abt1) plasma membrane (Chrna9) nucleus (Abt1)
DNA binding (Abt1)
Anatomy Link Frequency
ganglia 1
Abt1 (Mus musculus)
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 1 100.00 Very High Very High Very High
Nicotine 9 99.96 Very High Very High Very High
agonist 1 93.40 High High
Eae 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Electroencephalography 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 100.00 Very High Very High Very High
Anxiety Disorder 6 75.00 Quite High
Cognitive Disorder 4 75.00 Quite High
Toxicity 1 25.00 Low Low
Death 1 25.00 Low Low
Hypothermia 1 25.00 Low Low
Vomiting 1 25.00 Low Low
Convulsion 1 25.00 Low Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to (-)-nicotine, ABT 418 has reduced potency to interact with the subunit isoforms of nAChR found in sympathetic ganglia, and it does not compete for alpha-bungarotoxin binding sites in brain or at the neuromuscular junction.
ABT Binding (interact) of nAChR in ganglia associated with nicotine, reprotox - general 1 and potency
1) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7913497 Disease Relevance 0.31 Pain Relevance 0.26

General Comments

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