INT54466

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 5.44
Pain Relevance 10.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
juvenile 2
brain 2
amygdala 2
synapses 2
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 706 100.00 Very High Very High Very High
amygdala 166 100.00 Very High Very High Very High
depression 90 100.00 Very High Very High Very High
qutenza 81 100.00 Very High Very High Very High
Dopamine 60 99.78 Very High Very High Very High
antagonist 74 99.72 Very High Very High Very High
Anterior cingulate cortex 196 99.68 Very High Very High Very High
Dynorphin 3 99.52 Very High Very High Very High
Hippocampus 119 99.48 Very High Very High Very High
nMDA receptor 175 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 91 100.00 Very High Very High Very High
Stress 127 99.98 Very High Very High Very High
Convulsion 13 99.66 Very High Very High Very High
Li-fraumeni Syndrome 33 95.96 Very High Very High Very High
Targeted Disruption 64 91.92 High High
Cognitive Disorder 57 91.52 High High
Nociception 52 90.88 High High
Affective Disorder 2 88.64 High High
Disease 53 85.56 High High
Pain 111 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the suppressive effect of capsaicin on LA-LTP was also present in coronal slices derived from juvenile mice (control: 120.5±3.2% [n?
Negative_regulation (suppressive) of Gene_expression (effect) of LTP in juvenile associated with qutenza, long-term potentiation and amygdala
1) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.95
Inhibitors of transcription and translation may inhibit the expression of short-lived proteins required for E-LTP, since these inhibitors were added 30 min before the induction of potentiation.
Spec (may) Negative_regulation (inhibit) of Gene_expression (expression) of E-LTP associated with long-term potentiation
2) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.32 Pain Relevance 0.61
In support of this hypothesis, stimulation of dynorphin-containing fibers also blocked LTP production in an NBNI-sensitive manner.
Negative_regulation (blocked) of Gene_expression (production) of LTP associated with dynorphin and long-term potentiation
3) Confidence 0.34 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7913954 Disease Relevance 0 Pain Relevance 1.06
RESULTS: At 30 microM, propofol inhibited LTP induction produced by theta-burst stimulation but had less effect on LTP maintenance.
Negative_regulation (inhibited) of Gene_expression (produced) of LTP
4) Confidence 0.33 Published 2005 Journal Anesthesiology Section Body Doc Link 16052114 Disease Relevance 0 Pain Relevance 0
In previous reports, not only L-LTP but also E-LTP were inhibited by the MEK inhibitor, PD98059 [16,38].
Negative_regulation (inhibited) of Gene_expression (also) of E-LTP associated with long-term potentiation
5) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.91
Rats exposed to similar amounts of soman, but not displaying convulsions, also displayed reduced levels of LTP.
Negative_regulation (reduced) of Gene_expression (levels) of LTP associated with convulsion and long-term potentiation
6) Confidence 0.31 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9205805 Disease Relevance 0.43 Pain Relevance 0.42
LTP and production of NO were inhibited in the presence of the NO synthase inhibitors and an inhibitor of heme oxygenase, the synthetic enzyme for carbon monoxide (CO).
Negative_regulation (inhibited) of Gene_expression (production) of LTP associated with long-term potentiation
7) Confidence 0.28 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16623850 Disease Relevance 0.45 Pain Relevance 1.06
Studies have also shown that blocking SK channels facilitates the induction of LTP (Behnisch and Reymann, 1998; Stackman et al., 2002) and that genetic overexpression of SK2 channels inhibits LTP induction and hippocampal-dependent learning (Hammond et al., 2006).
Negative_regulation (inhibits) of Gene_expression (induction) of LTP associated with long-term potentiation
8) Confidence 0.25 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.53
Molecular mechanisms of LTP induction in the ACC
Negative_regulation (mechanisms) of Gene_expression (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
9) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.49 Pain Relevance 1.13
We found that propofol (30 microM) not only impaired LTP expression but also prevented LTP-accompanied downregulation of KCC2 without affecting the basal transmission of glutamatergic synapses.
Negative_regulation (impaired) of Gene_expression (expression) of LTP in synapses associated with long-term potentiation
10) Confidence 0.23 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.15 Pain Relevance 0.66
In the absence of corticosterone, LTP induction was impaired, pointing to an inverted U-shaped dose
Negative_regulation (impaired) of Gene_expression (induction) of LTP associated with long-term potentiation
11) Confidence 0.21 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1847472 Disease Relevance 0.43 Pain Relevance 0.45
Similarly, in hippocampal slices, low concentrations of NMDA also caused a reduction of LTP induction / expression in the CA1 region [109, 304].
Negative_regulation (reduction) of Gene_expression (expression) of LTP
12) Confidence 0.09 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.95 Pain Relevance 0.11
These findings provide a framework for explaining the pattern that acute stress disrupts the generation of LTP in mPFC and DH, while it simultaneously facilities LTP in the amygdala.
Negative_regulation (disrupts) of Gene_expression (generation) of LTP in amygdala associated with stress, hippocampus, long-term potentiation and amygdala
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 1.08 Pain Relevance 0.30
0.05, then stop testing and reject both hypotheses thus we conclude that both LTP groups are significantly different from the HEP group; otherwise the LTP group corresponding to the larger p value is claimed to be not significantly different from the HEP and continue to check the smaller p value p(1) ; if p(1) ?
Neg (not) Negative_regulation (different) of Gene_expression (group) of LTP
14) Confidence 0.07 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2222229 Disease Relevance 0.20 Pain Relevance 0.03
On the basis of the data demonstrating the downregulation of NR1, NR2A and NR2B subunit levels after prolonged UCB exposure, it was assumed that the decrease in the number of NMDA receptors may account for the inhibitory effects of UCB on LTP and LTD induction.
Negative_regulation (effects) of Gene_expression (induction) of LTP associated with depression, nmda receptor and long-term potentiation
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.24 Pain Relevance 0.41
Here, we show in brain slices that blocking DA receptors reduces the capacity of horizontal M1 connections to express LTP.
Negative_regulation (reduces) of Gene_expression (express) of LTP in brain associated with dopamine and long-term potentiation
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738964 Disease Relevance 0 Pain Relevance 0.67
This abolished LTP induction in all animals tested (Fig 2C; Table 1).
Negative_regulation (abolished) of Gene_expression (induction) of LTP associated with long-term potentiation
17) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.27 Pain Relevance 0.47
out by Bramham et al. [47], who demonstrated that unilateral LTP induction in
Negative_regulation (demonstrated) of Gene_expression (induction) of LTP associated with long-term potentiation
18) Confidence 0.03 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.06 Pain Relevance 0.37
min before LTP induction and thus 45?
Negative_regulation (min) of Gene_expression (induction) of LTP associated with long-term potentiation
19) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3006668 Disease Relevance 0.15 Pain Relevance 0.28
Peripheral pre-administration of bupivacaine (0.25%, 10 min prior to BV injection) completely inhibited BV-induced enhancement of LTP magnitude but not profoundly impaired the LTP induction (Fig. 10A, B).
Negative_regulation (impaired) of Gene_expression (induction) of LTP associated with long-term potentiation
20) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759921 Disease Relevance 0.21 Pain Relevance 0.45

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