INT54467

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 8.86
Pain Relevance 26.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spike 2
spinal 2
anterior 1
brain 1
midbrain 1
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 2107 100.00 Very High Very High Very High
depression 401 100.00 Very High Very High Very High
amygdala 283 100.00 Very High Very High Very High
Hippocampus 277 100.00 Very High Very High Very High
gABA 33 100.00 Very High Very High Very High
Dynorphin 3 99.98 Very High Very High Very High
qutenza 81 99.82 Very High Very High Very High
corticosteroid 33 99.68 Very High Very High Very High
nMDA receptor 214 99.64 Very High Very High Very High
spinal dorsal horn 95 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 419 100.00 Very High Very High Very High
Stress 144 99.92 Very High Very High Very High
Neuropathic Pain 44 98.84 Very High Very High Very High
Pain 250 98.56 Very High Very High Very High
Li-fraumeni Syndrome 100 98.08 Very High Very High Very High
Anaerobic Bacterial Infections 31 97.88 Very High Very High Very High
Anxiety Disorder 354 97.72 Very High Very High Very High
Hyperalgesia 48 96.04 Very High Very High Very High
Low Back Pain 19 94.00 High High
Injury 36 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO and CB1 receptors are involved in mediating capsaicin-induced reduction of LA-LTP
Localization (reduction) of LTP associated with qutenza, long-term potentiation and amygdala
1) Confidence 0.58 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.41
Accordingly, it is likely that the LTP induction stimuli readily recruit CaMKIV in membrane compartments, leading to protein synthesis.
Localization (recruit) of LTP associated with long-term potentiation
2) Confidence 0.55 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.65
Finally, dynorphin-mediated inhibition of LTP acts primarily on mechanisms of induction rather than maintenance or expression, since dynorphin released immediately before, but not immediately after, perforant path stimulation blocked LTP.
Neg (not) Localization (released) of LTP associated with dynorphin and long-term potentiation
3) Confidence 0.55 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7913954 Disease Relevance 0 Pain Relevance 1.05
Two-pathway stimulation experiments (Fig. 5) have confirmed that increase of proximal fEPSPs, as a result of LTP, was specific to the tetanised pathway and did not reflect a generalised heterosynaptic enhancement of post-synaptic excitability.
Localization (result) of LTP in proximal associated with long-term potentiation
4) Confidence 0.52 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.48
This is an agreement with published data on high sensitivity of LTP induced by these protocols to inhibition of NMDA receptors [71,75,76].
Localization (sensitivity) of LTP associated with nmda receptor and long-term potentiation
5) Confidence 0.52 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.07 Pain Relevance 0.49
In vivo Extracellular recordings of LTP in mice DH
Localization (recordings) of LTP associated with spinal dorsal horn and long-term potentiation
6) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.33 Pain Relevance 0.64
Therefore, we believe that Ca2+-permeable GluR2-lacking receptors contribute to the maintenance of LTP and are necessary for subsequent LTP stabilization.
Localization (stabilization) of LTP associated with long-term potentiation
7) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.47
Furthermore, new forms of LTP and LTD remain to be discovered to mimic physiological and/or pathological changes under in vivo conditions (e.g., presynaptic enhancement of neurotransmitter release after tissue injury in the anterior cingulate cortex (ACC) (see [6]).
Localization (forms) of LTP in anterior associated with neurotransmitter, injury, long-term potentiation and anterior cingulate cortex
8) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.27 Pain Relevance 0.66
Our data support an additional inhibition of SK channels that is critical for the facilitation of LTP.
Localization (facilitation) of LTP associated with long-term potentiation
9) Confidence 0.44 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.53
How to (and how not to) measure LTP
Localization (measure) of LTP associated with long-term potentiation
10) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.88 Pain Relevance 1.10
LTP induced by low frequency electrical nerve stimulation
Localization (stimulation) of LTP in nerve associated with long-term potentiation
11) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.38 Pain Relevance 1.43
facilitated LTP not only during elevation of
Localization (elevation) of LTP associated with long-term potentiation
12) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1847472 Disease Relevance 0.42 Pain Relevance 0.19
releasing hormone [34] increase LTP, the abundance of these hormones relative to that of corticosterone is very important in
Localization (releasing) of LTP associated with long-term potentiation
13) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1847472 Disease Relevance 0.53 Pain Relevance 0.66
to the effects of stress on LTP, learning, and memory is presently
Localization (learning) of LTP associated with stress and long-term potentiation
14) Confidence 0.38 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1847472 Disease Relevance 0.24 Pain Relevance 0.13
Rescue of tbLTP and Spatial Learning in Neto1-Null Mice by CX546
Localization (Rescue) of tbLTP
15) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.24 Pain Relevance 0.09
A persistent late phase of LTP (L-LTP) in cortical and thalamic inputs to the LA, which is induced by repeated high frequency trains of presynaptic stimulation and is dependent on new protein synthesis, was found to be mediated by activation of ?
Localization (phase) of L-LTP associated with long-term potentiation
16) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.40 Pain Relevance 0.52
A persistent late phase of LTP (L-LTP) in cortical and thalamic inputs to the LA, which is induced by repeated high frequency trains of presynaptic stimulation and is dependent on new protein synthesis, was found to be mediated by activation of ?
Localization (phase) of LTP associated with long-term potentiation
17) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.40 Pain Relevance 0.52
ERK was found to be required for the early phase of LTP elicited by brief presynaptic stimulation, as well as for LTP elicited by prolonged stimulation paired with ?
Localization (elicited) of LTP associated with long-term potentiation
18) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.07 Pain Relevance 0.49
It has been suggested that E-LTP (or LTP1) can be transformed into L-LTP (LTP3), probably via an intermediate LTP2 form (Reymann and Frey 2007).
Localization (transformed) of LTP3 associated with long-term potentiation
19) Confidence 0.35 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.06 Pain Relevance 0.81
NR2B-NMDARs are required for LTP induced by the spike-timing protocol, but not by the pairing protocol.
Localization (required) of LTP in spike associated with long-term potentiation
20) Confidence 0.34 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.15 Pain Relevance 0.52

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