INT54473

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2011
Negated 3
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 8.65
Pain Relevance 10.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
brain 3
Claw 2
hepatocytes 1
intestinal epithelium 1
band 1
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 80 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
adenocard 3 99.74 Very High Very High Very High
Opioid 13 99.54 Very High Very High Very High
methadone 10 98.52 Very High Very High Very High
antagonist 10 98.44 Very High Very High Very High
opioid receptor 5 98.22 Very High Very High Very High
methotrexate 40 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 129 100.00 Very High Very High Very High
Inflammatory Bowel Disease 10 100.00 Very High Very High Very High
Tics 9 99.54 Very High Very High Very High
Biliary Liver Cirrhosis 8 99.52 Very High Very High Very High
Colon Cancer 153 99.36 Very High Very High Very High
Pain 10 98.24 Very High Very High Very High
Cancer 58 97.28 Very High Very High Very High
Overdose 3 97.28 Very High Very High Very High
INFLAMMATION 43 92.08 High High
Arrhythmia Under Development 2 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our results demonstrate for the first time that Devil's Claw may interact with the multidrug transporter ABCB1/P-gp, the effect not appearing strictly related to the harpagoside relative content.
P-gp Neg (not) Binding (interact) of in Claw
1) Confidence 0.48 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.12 Pain Relevance 0
It has recently been reported that a particular arrangement of polar groups and spatial separation distances is required for substrate recognition by P-glycoprotein.
P-glycoprotein Binding (recognition) of
2) Confidence 0.47 Published 1999 Journal J. Pept. Res. Section Abstract Doc Link 10406218 Disease Relevance 0 Pain Relevance 0.19
These results show that the nucleotide-binding domains are not required for interaction of P-gp with substrate or for trafficking of P-gp to the cell surface.
P-gp Binding (interaction) of
3) Confidence 0.47 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10455147 Disease Relevance 0 Pain Relevance 0.08
UNLABELLED: Loperamide is a peripherally acting antidiarrheal opioid with some affinity for P-glycoprotein (P-gp).
P-glycoprotein Binding (affinity) of associated with opioid
4) Confidence 0.47 Published 2004 Journal Drug Dev Ind Pharm Section Abstract Doc Link 15244080 Disease Relevance 0 Pain Relevance 0.15
CONCLUSIONS: Our results demonstrate for the first time that Devil's Claw may interact with the multidrug transporter ABCB1/P-gp, the effect not appearing strictly related to the harpagoside relative content.
ABCB1 Neg (not) Binding (interact) of in Claw
5) Confidence 0.47 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.12 Pain Relevance 0
P85 was examined in vitro to assess blood-brain barrier uptake in association with P-glycoprotein effect, DPDPE and morphine being P-glycoprotein substrates.
P-glycoprotein Binding (association) of in brain associated with morphine
6) Confidence 0.47 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388663 Disease Relevance 0 Pain Relevance 1.16
MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.
MDR1 Binding (interaction) of
7) Confidence 0.46 Published 2002 Journal Biol. Pharm. Bull. Section Title Doc Link 12499648 Disease Relevance 0 Pain Relevance 0.08
-actin band for the protein and the ratio of the P-gp was normalized by dividing by the ratio of the ?
P-gp Binding (ratio) of in band
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
P85 was examined in vitro to assess blood-brain barrier uptake in association with P-glycoprotein effect, DPDPE and morphine being P-glycoprotein substrates.
P-glycoprotein Binding (association) of in brain associated with morphine
9) Confidence 0.36 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388663 Disease Relevance 0 Pain Relevance 1.24
The results suggest that the HT29-MTX model can be used to rank order the passive permeability of compounds, irrespective of their potential interaction with P-gp, which may facilitate optimization of the physicochemical features of compounds within a chemical series.
P-gp Binding (interaction) of
10) Confidence 0.36 Published 2001 Journal J Pharm Sci Section Abstract Doc Link 11745719 Disease Relevance 0.08 Pain Relevance 0.09
Absorption of the drug across the intestinal epithelium is complex, involving P-glycoprotein-mediated secretion and saturable binding to intestinal mucus (Langguth et al 1997).
P-glycoprotein Binding (complex) of in intestinal epithelium
11) Confidence 0.36 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661617 Disease Relevance 0 Pain Relevance 0.27
These results show that the nucleotide-binding domains are not required for interaction of P-gp with substrate or for trafficking of P-gp to the cell surface.
P-gp Binding (trafficking) of
12) Confidence 0.36 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10455147 Disease Relevance 0 Pain Relevance 0.08
The human multidrug resistance P-glycoprotein (P-gp) is organized in two tandem repeats with each repeat consisting of an N-terminal hydrophobic domain containing six potential transmembrane segments followed by a hydrophilic domain containing a nucleotide-binding fold.
P-gp Binding (organized) of
13) Confidence 0.36 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10455147 Disease Relevance 0 Pain Relevance 0
In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P-glycoprotein were associated with the concentrations of R- and S-methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine.
P-glycoprotein Binding (associated) of associated with methadone
14) Confidence 0.36 Published 2010 Journal J. Forensic Sci. Section Abstract Doc Link 20102450 Disease Relevance 0.07 Pain Relevance 0.91
We have previously found interaction between meat intake and polymorphisms in the xenobiotic transporter MDR1 in relation to CRC in this study group [20].
MDR1 Binding (interaction) of associated with colon cancer
15) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.32 Pain Relevance 0
We have recently found interaction between meat intake and polymorphisms in the ATP-binding cassette (ABC) transporter B1 (ABCB1, MDR1) which encodes glycoprotein P involved in reverse transport of carcinogens and other xenobiotic substances [20].
MDR1 Binding (binding) of
16) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 1.11 Pain Relevance 0.29
We have recently found interaction between meat intake and polymorphisms in the ATP-binding cassette (ABC) transporter B1 (ABCB1, MDR1) which encodes glycoprotein P involved in reverse transport of carcinogens and other xenobiotic substances [20].
ABCB1 Binding (binding) of
17) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 1.11 Pain Relevance 0.29
A higher weight (P = .05) and the ABCB1 homozygous GG-CC diplotype (P = .03) were significantly associated with fewer morphine side effects by univariate analysis.
ABCB1 Binding (associated) of
18) Confidence 0.34 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16580900 Disease Relevance 0 Pain Relevance 0
Increased P-gp protein was confirmed immunohistochemically and was found to localize to areas of PCNA-positive hepatocytes, which were detected in APAP overdose and PBC livers.
P-gp protein Binding (localize) of in hepatocytes associated with biliary liver cirrhosis, paracetamol and overdose
19) Confidence 0.29 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.40 Pain Relevance 0.58
The peptides that show high-affinity interaction with the MDR1-ATPase also interfere strongly with fluorescent dye extrusion catalyzed by the multidrug transporter in intact cells and some have been shown to reverse drug resistance in cultured cells.
MDR1 Binding (interaction) of
20) Confidence 0.27 Published 1994 Journal FASEB J. Section Abstract Doc Link 7914178 Disease Relevance 0 Pain Relevance 0.09

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