INT54484

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Npepo) aging (Fos) nucleolus (Fos)
nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
striatum 2
Npepo (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 36 100.00 Very High Very High Very High
nMDA receptor antagonist 3 99.60 Very High Very High Very High
Dopamine 24 98.08 Very High Very High Very High
agonist 15 96.68 Very High Very High Very High
Substantia nigra 3 50.40 Quite High
Opioid 3 42.56 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While co-administration of the NMDA receptor antagonist, MK-801, inhibited APO-induced increases in DYN and Fos/FRA expression in the intact striatum, its only effect in the DA-denervated striatum was a partial (35%) inhibition of the APO-induced increase in DYN-ir concentrations.
APO Positive_regulation (increases) of Gene_expression (expression) of Fos in striatum associated with dopamine, nmda receptor antagonist and dynorphin
1) Confidence 0.43 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.48
Paralleling the increase in DYN expression, APO also induced the expression of c-Fos and Fos-related antigens (FRA's), in particular a 35 kDa FRA, but had no effect on the expression of various Jun-related IEG proteins (i.e., c-Jun, Jun B, Jun D).
APO Positive_regulation (induced) of Gene_expression (expression) of Fos associated with dynorphin
2) Confidence 0.31 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.57
Paralleling the increase in DYN expression, APO also induced the expression of c-Fos and Fos-related antigens (FRA's), in particular a 35 kDa FRA, but had no effect on the expression of various Jun-related IEG proteins (i.e., c-Jun, Jun B, Jun D).
APO Positive_regulation (induced) of Gene_expression (expression) of Fos associated with dynorphin
3) Confidence 0.31 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.57

General Comments

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