INT54489

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Context Info
Confidence 0.16
First Reported 1994
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.48
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun) cytoplasm (Rabep2)
Anatomy Link Frequency
hippocampus 2
striatum 1
Jun (Rattus norvegicus)
Rabep2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 12 99.44 Very High Very High Very High
Dynorphin 36 98.00 Very High Very High Very High
Dopamine 24 97.12 Very High Very High Very High
nMDA receptor antagonist 3 89.84 High High
agonist 15 86.92 High High
Substantia nigra 3 40.64 Quite Low
Opioid 3 32.80 Quite Low
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 21 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Super-shift showed that only Fra and Jun D antibodies could super-shift AP-1 complex to a higher position.
AP-1 Binding (complex) of Fra
1) Confidence 0.16 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.49 Pain Relevance 0.18
It suggested that the AP-1 complex was composed of Fra and Jun D in hippocampus of the seizure-sensitive rats.
AP-1 Binding (complex) of Fra in hippocampus associated with convulsion and hippocampus
2) Confidence 0.16 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.18
It suggested that the AP-1 complex was composed of Fra and Jun D in hippocampus of the seizure-sensitive rats.
AP-1 Binding (complex) of Fra in hippocampus associated with convulsion and hippocampus
3) Confidence 0.16 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.18
Consistent with the notion that Fos and FRA proteins alter transcriptional activity by binding to AP-1 (or AP-1-like) DNA sequences in the promoter regions of target genes, we found that repeated APO treatment caused large increases in AP-1 binding activity in striata ipsilateral to 6-OHDA lesions.
AP-1 Binding (binding) of FRA
4) Confidence 0.10 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.62
Consistent with the notion that Fos and FRA proteins alter transcriptional activity by binding to AP-1 (or AP-1-like) DNA sequences in the promoter regions of target genes, we found that repeated APO treatment caused large increases in AP-1 binding activity in striata ipsilateral to 6-OHDA lesions.
AP-1 Binding (binding) of FRA
5) Confidence 0.10 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.62
These data indicate that repeated activation of D1 receptors increases both the expression of a 35 kDa FRA and AP-1 binding, events which may mediate the large increases in DYN expression in the DA denervated striatum.
AP-1 Binding (binding) of FRA in striatum associated with dopamine and dynorphin
6) Confidence 0.09 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.52

General Comments

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