INT54491

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Context Info
Confidence 0.00
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1, Jun) cytoplasm (Akr1d1, Rabep2) aging (Jun)
oxidoreductase activity (Akr1d1) nucleus (Jun) DNA binding (Jun)
Anatomy Link Frequency
striatum 3
Akr1d1 (Rattus norvegicus)
Jun (Rattus norvegicus)
Rabep2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 12 98.00 Very High Very High Very High
Dopamine 8 97.12 Very High Very High Very High
nMDA receptor antagonist 1 89.84 High High
agonist 5 75.16 Quite High
Substantia nigra 1 28.88 Quite Low
Opioid 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that repeated activation of D1 receptors increases both the expression of a 35 kDa FRA and AP-1 binding, events which may mediate the large increases in DYN expression in the DA denervated striatum.
Positive_regulation (activation) of D1 in striatum Positive_regulation (increases) of AP-1 Binding (binding) of FRA in striatum associated with dopamine and dynorphin
1) Confidence 0.00 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.53

General Comments

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