INT54492

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.19
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Otc) cellular amino acid metabolic process (Otc) cytoplasm (Otc)
Anatomy Link Frequency
brain 2
Otc (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 98.40 Very High Very High Very High
anesthesia 4 98.16 Very High Very High Very High
monoamine 4 96.12 Very High Very High Very High
medulla 2 94.40 High High
cerebral cortex 1 81.84 Quite High
excitatory amino acid 3 31.12 Quite Low
Disease Link Frequency Relevance Heat
Hyperammonemia 4 99.34 Very High Very High Very High
Convulsion 6 96.76 Very High Very High Very High
Intellectual Impairment 3 96.24 Very High Very High Very High
Ornithine Transcarbamylase Deficiency 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Congenital deficiencies of the urea cycle enzyme ornithine transcarbamylase (OTC) result in chronic hyperammonemia and severe neurological dysfunction including seizures and mental retardation.
Negative_regulation (deficiencies) of ornithine transcarbamylase associated with hyperammonemia, anesthesia, intellectual impairment and convulsion
1) Confidence 0.43 Published 1994 Journal Metab Brain Dis Section Abstract Doc Link 7914668 Disease Relevance 0.37 Pain Relevance 0.17
Congenital deficiencies of the urea cycle enzyme ornithine transcarbamylase (OTC) result in chronic hyperammonemia and severe neurological dysfunction including seizures and mental retardation.
Negative_regulation (deficiencies) of OTC associated with hyperammonemia, anesthesia, intellectual impairment and convulsion
2) Confidence 0.43 Published 1994 Journal Metab Brain Dis Section Abstract Doc Link 7914668 Disease Relevance 0.37 Pain Relevance 0.17
As part of a series of studies to elucidate the pathophysiologic mechanisms responsible for the CNS consequences of OTC deficiency, concentrations of ammonia-related and neurotransmitter amino acids were measured as their o-phthalaldehyde derivatives using high performance liquid chromatography with fluorescence detection in regions of the brains of sparse-fur (spf) mice, a mutant with an X-linked inherited defect of OTC.
Negative_regulation (deficiency) of OTC in brains associated with neurotransmitter
3) Confidence 0.38 Published 1994 Journal Metab Brain Dis Section Abstract Doc Link 7914668 Disease Relevance 0.36 Pain Relevance 0.18
Activities of monoamine oxidases, MAOA and MAOB, were measured using radiometric assays in different brain regions of the sparse-fur (spf/Y) mouse, a model of congenital hyperammonemia resulting from an X-chromosomal defect of ornithine transcarbamylase.
Negative_regulation (defect) of transcarbamylase in brain associated with hyperammonemia and monoamine
4) Confidence 0.32 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041507 Disease Relevance 0.10 Pain Relevance 0.35

General Comments

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