INT54495

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.82
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
Anatomy Link Frequency
muscle 1
brain 1
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABA receptor 8 100.00 Very High Very High Very High
gABA 26 99.84 Very High Very High Very High
agonist 47 98.84 Very High Very High Very High
Gabapentin 45 98.30 Very High Very High Very High
Neurotransmitter 6 95.52 Very High Very High Very High
Action potential 2 94.32 High High
anticonvulsant 3 93.52 High High
opiate 1 91.44 High High
antagonist 14 90.88 High High
addiction 2 90.64 High High
Disease Link Frequency Relevance Heat
Epilepsy 3 97.48 Very High Very High Very High
Anxiety Disorder 2 95.40 Very High Very High Very High
Drug Dependence 1 90.64 High High
Schizophrenia 33 89.88 High High
Depression 7 89.28 High High
Pain 6 88.80 High High
Spasticity 32 88.24 High High
Neurodegenerative Disease 1 85.68 High High
Sleep Disorders 64 83.80 Quite High
Cognitive Disorder 1 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterodimeric GABAB receptors, GABABR1 binds the ligand while GABABR2 couples to the G protein and is required for targeting GABABR1 to the membrane (Brauner-Osborne et al., 2007).
GABABR1 Binding (binds) of
1) Confidence 0.35 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0 Pain Relevance 0
The petit mal epileptic effects of GHB might be ascribed to its direct, or indirect agonist properties after transformation to a pool of GABA at the GABAB receptor or via interactions at its own binding sites linked to a similar series of biochemical events.
GABAB Binding (interactions) of associated with epilepsy, gaba and agonist
2) Confidence 0.19 Published 1994 Journal Neurosci Biobehav Rev Section Abstract Doc Link 7914688 Disease Relevance 0.30 Pain Relevance 0.76
Unfortunately, most benzodiazepines interact with the entire GABA receptor complex, creating several of these effects simultaneously.
GABA receptor Binding (interact) of associated with gaba receptor
3) Confidence 0.15 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.44 Pain Relevance 0.28
It was synthesized as a structural analog of GABA, which is a well-known inhibitory neurotransmitter in the brain, with the hope that it would penetrate into the brain and have a GABA-mimetic effect.14 The mechanism of action of gabapentin is not yet fully understood, and there is no convincing evidence to suggest that it interacts with GABAA or GABAB receptors.
GABAB Binding (interacts) of in brain associated with neurotransmitter, gaba and gabapentin
4) Confidence 0.13 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.29 Pain Relevance 1.10
It binds to GABA receptor at the presynaptic terminal and inhibits muscle stretch reflex.
GABA receptor Binding (binds) of in muscle associated with gaba receptor
5) Confidence 0.08 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009478 Disease Relevance 0.18 Pain Relevance 0.26
This information helped to identify a phospholipid ligand for GPRC (H.
GPRC Binding (ligand) of
6) Confidence 0.04 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04
The most unambiguous example of trans-activation has been described for the GABAB1-GABAB2 heterodimer, where the ligand-bound subunit (GABAB1) does not appear to couple to the G-protein, but the other subunit (GABAB2) within the hetero-dimer can bind the G-protein, but not the ligand [50].
GABAB2 Neg (not) Binding (bind) of
7) Confidence 0.02 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The most unambiguous example of trans-activation has been described for the GABAB1-GABAB2 heterodimer, where the ligand-bound subunit (GABAB1) does not appear to couple to the G-protein, but the other subunit (GABAB2) within the hetero-dimer can bind the G-protein, but not the ligand [50].
GABAB2 Neg (not) Binding (bind) of
8) Confidence 0.02 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
The GABAB1 subunit binds the endogenous ligand within its extracellular N-terminus, whilst the GABAB2 subunit is not only essential for the correct trafficking of the GABAB1 subunit to the cell surface, but is also responsible for the interaction of the receptor with its cognate G-protein.
GABAB2 subunit Binding (binds) of
9) Confidence 0.01 Published 2005 Journal CNS Drug Rev Section Abstract Doc Link 16389296 Disease Relevance 0.62 Pain Relevance 0.31

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