INT545

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Context Info
Confidence 0.45
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 10.74
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GC) extracellular space (GC) small molecule metabolic process (GC)
extracellular region (GC)
Anatomy Link Frequency
plasma 3
epithelial cells 2
blood 1
GC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
Codeine 11 99.74 Very High Very High Very High
Pain 26 99.56 Very High Very High Very High
imagery 7 98.80 Very High Very High Very High
rheumatoid arthritis 28 97.20 Very High Very High Very High
Chronic low back pain 1 79.60 Quite High
Lasting pain 8 78.68 Quite High
adenocard 12 77.56 Quite High
cINOD 1 73.76 Quite High
addiction 10 67.76 Quite High
Disease Link Frequency Relevance Heat
Acute Renal Failure 2 99.76 Very High Very High Very High
Pain 31 99.56 Very High Very High Very High
Renal Disease 5 99.44 Very High Very High Very High
Sickle Cell Anemia 7 97.92 Very High Very High Very High
Rheumatoid Arthritis 28 97.20 Very High Very High Very High
Nephrosis 1 96.84 Very High Very High Very High
Syndrome 5 96.70 Very High Very High Very High
Insulin Resistance 32 96.36 Very High Very High Very High
Endometriosis (extended) 17 96.00 Very High Very High Very High
Bone Fracture 1 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover.
Vitamin D-binding protein Binding (binds) of
1) Confidence 0.45 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17347552 Disease Relevance 0.65 Pain Relevance 0.09
Physiologically, 25(OH)D is filtrated in complex with vitamin D binding protein (DBP) by the glomeruli and re-absorbed by proximal tubular epithelial cells [23].
DBP Binding (complex) of in epithelial cells
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.53 Pain Relevance 0.06
Pain catastrophizing also interacted with SBP, DBP and HR reactivity to affect pain such that high catastrophizers who showed low cardiovascular reactivity to the interviews reported the greatest pain.
DBP Binding (interacted) of associated with pain
3) Confidence 0.36 Published 2008 Journal J Behav Med Section Abstract Doc Link 18158618 Disease Relevance 1.54 Pain Relevance 1.55
Altogether 85 patients with the painful syndromes in the facial and head areas were examined for secretion and transport of testosterone, the main androgen occurring in the body of adult man, by the blood proteins globulin- and albumin-binding sex steroids.
globulin Binding (binding) of in blood associated with pain and syndrome
4) Confidence 0.24 Published 1990 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 2171263 Disease Relevance 0.34 Pain Relevance 0.10
Physiologically, 25(OH)D is filtrated in complex with vitamin D binding protein (DBP) by the glomeruli and re-absorbed by proximal tubular epithelial cells [23].
vitamin D binding protein Binding (complex) of in epithelial cells
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.53 Pain Relevance 0.06
Intravenous immune globulin and hydroxyethyl starch, a new plasma expander, are associated with acute renal failure with characteristic renal histology known as osmotic nephrosis.
immune globulin Binding (associated) of in plasma associated with nephrosis and acute renal failure
6) Confidence 0.12 Published 2005 Journal Ren Fail Section Abstract Doc Link 15957551 Disease Relevance 1.62 Pain Relevance 0.07
The interaction of (N-methyl-14C) morphine with purified human albumin and gamma globulin and with human plasma was studied by equilibrium dialysis.
globulin Binding (interaction) of in plasma associated with morphine
7) Confidence 0.12 Published 1975 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 47279 Disease Relevance 0 Pain Relevance 0.50
Progesterone, estrogen and their metabolites, after binding to human tissue proteins, such as albumin or globulin, may act as antigens and promote Type 2 helper cell development, thereby regulating antibody synthesis and allergy.
globulin Binding (binding) of
8) Confidence 0.10 Published 2006 Journal Am. J. Reprod. Immunol. Section Body Doc Link 16533343 Disease Relevance 0.12 Pain Relevance 0
Serum sex hormone binding globulin was elevated.
globulin Binding (binding) of
9) Confidence 0.04 Published 2003 Journal South. Med. J. Section Abstract Doc Link 14513996 Disease Relevance 0.99 Pain Relevance 0.12
Codeine is known to bind to gamma-globulin, a fact that may explain in part the observed increase in the plasma protein binding of codeine in sickle cell patients.
gamma-globulin Binding (bind) of in plasma associated with sickle cell anemia and codeine
10) Confidence 0.04 Published 1993 Journal J Pharm Sci Section Abstract Doc Link 8289123 Disease Relevance 0.47 Pain Relevance 0.63
The best measure is bio-available testosterone which is the fraction of testosterone not bound to sex hormone binding globulin.
globulin Binding (bound) of
11) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Abstract Doc Link PMC2686330 Disease Relevance 0.88 Pain Relevance 0
The best measure is bio-available testosterone which is the fraction of testosterone not bound to sex hormone binding globulin.
globulin Binding (bound) of
12) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Abstract Doc Link PMC2686330 Disease Relevance 0.88 Pain Relevance 0
Mean non-sex hormone binding globulin-bound testosterone (bioavailable testosterone) was lower in men with rheumatoid arthritis for each of the three groups.
globulin Binding (binding) of associated with rheumatoid arthritis
13) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 1.61 Pain Relevance 0.22
Of even greater significance is the steeper fall of the most biologically active fraction of total testosterone, non-sex hormone binding globulin (SHBG)- bound testosterone, or bioavailable testosterone (bio-T).
globulin Binding (binding) of
14) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 0.24 Pain Relevance 0
Conversely, TU treatment was associated with a significant decrease in sex hormoneĀ–binding globulin, follicular-stimulating hormone, and luteinizing hormone (all p <0.001).
globulin Binding (binding) of
15) Confidence 0.02 Published 2008 Journal Am J Cardiol Section Body Doc Link PMC2258313 Disease Relevance 0.28 Pain Relevance 0.03
Dihydrotestosterone significantly increased and sex hormoneĀ–binding globulin, luteinizing hormone, and follicular-stimulating hormone decreased after TU administration.
globulin Binding (binding) of
16) Confidence 0.02 Published 2008 Journal Am J Cardiol Section Body Doc Link PMC2258313 Disease Relevance 0.06 Pain Relevance 0.04

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