INT54506

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 6.68
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (KRR1) RNA binding (KRR1) nucleus (KRR1)
cytoplasm (KRR1)
Anatomy Link Frequency
liver 1
KRR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatica 2 99.72 Very High Very High Very High
opioid receptor 1 99.70 Very High Very High Very High
Osteoarthritis 3 99.24 Very High Very High Very High
Opioid 2 98.94 Very High Very High Very High
alcohol 4 98.76 Very High Very High Very High
Morphine 3 98.56 Very High Very High Very High
Fibrositis 10 98.36 Very High Very High Very High
methadone 7 97.76 Very High Very High Very High
Analgesic 1 91.76 High High
Enkephalin 4 88.40 High High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 23 100.00 Very High Very High Very High
Hepatitis 15 100.00 Very High Very High Very High
Nerve Root Compression 2 99.72 Very High Very High Very High
Osteoarthritis 3 99.24 Very High Very High Very High
Sleep Disorders 7 98.36 Very High Very High Very High
Chronic Hepatitis 7 97.38 Very High Very High Very High
Viral Infection 2 95.40 Very High Very High Very High
Infection 5 93.16 High High
Blister 1 85.52 High High
Hepatitis Virus Infection 5 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies have shown that morphine, which exerts its effects by binding to opioid receptors, enhances the expression of hepatitis C RNA in hepatitis C-replicon containing liver cells, and that it interferes with the antiviral effect of interferon on the hepatitis C virus.
Gene_expression (expression) of hepatitis C in liver associated with opioid receptor, hepatitis and morphine
1) Confidence 0.75 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 17692472 Disease Relevance 0.75 Pain Relevance 0.66
The hepatitis C virus (HCV) antibody was present in each case.
Gene_expression (present) of hepatitis C associated with hepatitis c virus infection and hepatitis
2) Confidence 0.65 Published 1994 Journal J. Dermatol. Section Abstract Doc Link 7914899 Disease Relevance 1.76 Pain Relevance 0.22
One hundred patients with chronic hepatitis C, 50 on methadone maintenance, and 50 with no intravenous drug use or opioid maintenance for at least 5 years were prospectively matched for sex, age, hepatitis C virus (HCV) genotype and HCV RNA.
Gene_expression (matched) of hepatitis C associated with chronic hepatitis, methadone, hepatitis c virus infection, opioid and hepatitis
3) Confidence 0.65 Published 2004 Journal Hepatology Section Abstract Doc Link 15239094 Disease Relevance 0.82 Pain Relevance 0.43
Anti-HCV antibodies were found in 7/152 (4.6%) patients suffering from FM and in 5/152 (3.3%) of control subjects.
Gene_expression (found) of HCV associated with hepatitis c virus infection and fibrositis
4) Confidence 0.65 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17943229 Disease Relevance 2.21 Pain Relevance 0.59
No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels.
Gene_expression (levels) of hepatitis C virus associated with hepatitis c virus infection and hepatitis
5) Confidence 0.65 Published 2008 Journal Hepatology Section Abstract Doc Link 18157835 Disease Relevance 1.14 Pain Relevance 0.19

General Comments

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