INT54506

Context Info Confidence 0.75 First Reported 1994 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 6.68 Pain Relevance 2.10

nucleolus (KRR1) RNA binding (KRR1) nucleus (KRR1) cytoplasm (KRR1)

Anatomy Link Frequency liver 1 KRR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Sciatica 2 99.72 opioid receptor 1 99.70 Osteoarthritis 3 99.24 Opioid 2 98.94 alcohol 4 98.76 Morphine 3 98.56 Fibrositis 10 98.36 methadone 7 97.76 Analgesic 1 91.76 Enkephalin 4 88.40

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 23 100.00 Hepatitis 15 100.00 Nerve Root Compression 2 99.72 Osteoarthritis 3 99.24 Sleep Disorders 7 98.36 Chronic Hepatitis 7 97.38 Viral Infection 2 95.40 Infection 5 93.16 Blister 1 85.52 Hepatitis Virus Infection 5 83.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vitro studies have shown that morphine, which exerts its effects by binding to opioid receptors, enhances the expression of hepatitis C RNA in hepatitis C-replicon containing liver cells, and that it interferes with the antiviral effect of interferon on the hepatitis C virus.

Gene_expression (expression) of hepatitis C in liver associated with opioid receptor, hepatitis and morphine

1) Confidence 0.75 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 17692472 Disease Relevance 0.75 Pain Relevance 0.66

The hepatitis C virus (HCV) antibody was present in each case.

Gene_expression (present) of hepatitis C associated with hepatitis c virus infection and hepatitis

2) Confidence 0.65 Published 1994 Journal J. Dermatol. Section Abstract Doc Link 7914899 Disease Relevance 1.76 Pain Relevance 0.22

One hundred patients with chronic hepatitis C, 50 on methadone maintenance, and 50 with no intravenous drug use or opioid maintenance for at least 5 years were prospectively matched for sex, age, hepatitis C virus (HCV) genotype and HCV RNA.

Gene_expression (matched) of hepatitis C associated with chronic hepatitis, methadone, hepatitis c virus infection, opioid and hepatitis

3) Confidence 0.65 Published 2004 Journal Hepatology Section Abstract Doc Link 15239094 Disease Relevance 0.82 Pain Relevance 0.43

Anti-HCV antibodies were found in 7/152 (4.6%) patients suffering from FM and in 5/152 (3.3%) of control subjects.

Gene_expression (found) of HCV associated with hepatitis c virus infection and fibrositis

4) Confidence 0.65 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17943229 Disease Relevance 2.21 Pain Relevance 0.59

No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels.

Gene_expression (levels) of hepatitis C virus associated with hepatitis c virus infection and hepatitis

5) Confidence 0.65 Published 2008 Journal Hepatology Section Abstract Doc Link 18157835 Disease Relevance 1.14 Pain Relevance 0.19

General Comments

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