INT5451

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Context Info
Confidence 0.28
First Reported 1986
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRH, POMC) signal transduction (CRH, POMC) extracellular region (CRH, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
plasma 1
CRH (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 2 100.00 Very High Very High Very High
carbamazepine 19 99.68 Very High Very High Very High
Opioid 2 87.44 High High
narcan 1 85.48 High High
Pain 1 64.04 Quite High
anticonvulsant 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cushing's Syndrome /

Hypercortisolism

3 99.82 Very High Very High Very High
Affective Disorder 1 64.84 Quite High
Pain 1 64.04 Quite High
Convulsion 1 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (CRF).
CRF Regulation (Regulation) of beta-endorphin associated with dynorphin
1) Confidence 0.28 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2893273 Disease Relevance 0 Pain Relevance 0.31
Despite the CBZ-induced hypercortisolism, plasma ACTH responses to CRH during CBZ treatment remained robust, rather than being suppressed by basal hypercortisolism.
CRH Regulation (responses) of ACTH in plasma associated with carbamazepine
2) Confidence 0.18 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1309836 Disease Relevance 0.19 Pain Relevance 0.54

General Comments

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